Adil Khan
adilgkhan.bsky.social
Adil Khan
@adilgkhan.bsky.social
Neuroscientist, group leader at King's College London
www.khanlab.net
We published this recently
www.cell.com/neuron/fullt...

Its to do with the orthogonality of two distinct modulations (attention and VIP disinhibition) on the same population. We use the approach from Elsayed, Cunningham et al 2016 to find orthogonality.
Disinhibition by VIP interneurons is orthogonal to cross-modal attentional modulation in primary visual cortex
Attentional modulation of sensory processing is a critical aspect of cognition, but its neural circuit basis is poorly understood. Previous work implicates VIP interneurons as critical to this modulation. Myers-Joseph et al. demonstrate that modulations by VIP interneurons and attention are in fact orthogonal, allowing multiplexing diverse signals in V1.
www.cell.com
January 1, 2025 at 4:33 PM