Aaron Cox, PhD
@aaronrcox.bsky.social
Islet biologist interested in metabolism, obesity, diabetes | Asst. Prof UTHealth
Importantly there is a deficiency in basic science translation and clinical studies including women or female pre-clinical models #InclusionMatters. Everyone equally deserves breakthrough medications treatments and cures for illnesses. It all begins with NIH funded basic science to study diversity
February 20, 2025 at 5:36 PM
Importantly there is a deficiency in basic science translation and clinical studies including women or female pre-clinical models #InclusionMatters. Everyone equally deserves breakthrough medications treatments and cures for illnesses. It all begins with NIH funded basic science to study diversity
Ultimately, we propose a coordinated transcriptional mechanism involving Xbp1 and Myc to alleviate UPR and stimulate beta cell proliferation in obese female mice
February 20, 2025 at 5:36 PM
Ultimately, we propose a coordinated transcriptional mechanism involving Xbp1 and Myc to alleviate UPR and stimulate beta cell proliferation in obese female mice
We unify independent observations of UPR (Laura Alonso
@JimJohnsonSci Jesper Gromada) and Myc (Vincent Poitout Adolfo Garcia Ocaña Donald Scott Andy Stewart) regulated beta cell proliferation, while identifying novel aspects of stress attenuation and Myc transcriptional co-regulators
@JimJohnsonSci Jesper Gromada) and Myc (Vincent Poitout Adolfo Garcia Ocaña Donald Scott Andy Stewart) regulated beta cell proliferation, while identifying novel aspects of stress attenuation and Myc transcriptional co-regulators
February 20, 2025 at 5:36 PM
We unify independent observations of UPR (Laura Alonso
@JimJohnsonSci Jesper Gromada) and Myc (Vincent Poitout Adolfo Garcia Ocaña Donald Scott Andy Stewart) regulated beta cell proliferation, while identifying novel aspects of stress attenuation and Myc transcriptional co-regulators
@JimJohnsonSci Jesper Gromada) and Myc (Vincent Poitout Adolfo Garcia Ocaña Donald Scott Andy Stewart) regulated beta cell proliferation, while identifying novel aspects of stress attenuation and Myc transcriptional co-regulators
High confidence transcriptional target (HCT) analysis (McKenna/Ochsner) lead us to identify the enrichment of specific Myc co-regulators (Hcfc1 and Wdr5) that may determine specific gene programs activated by Myc during UPR and Xbp-1 activation to drive beta cell proliferation
February 20, 2025 at 5:36 PM
High confidence transcriptional target (HCT) analysis (McKenna/Ochsner) lead us to identify the enrichment of specific Myc co-regulators (Hcfc1 and Wdr5) that may determine specific gene programs activated by Myc during UPR and Xbp-1 activation to drive beta cell proliferation
Acute Lepr KO induces an Xbp1 regulated transcriptional program to resolve UPR stress during adaptive beta cell proliferation. UPR resolution involved attenuation of HSF1 gene regulation and increased ribosomal biogenesis associated with prominent MYC transcriptional activity
February 20, 2025 at 5:36 PM
Acute Lepr KO induces an Xbp1 regulated transcriptional program to resolve UPR stress during adaptive beta cell proliferation. UPR resolution involved attenuation of HSF1 gene regulation and increased ribosomal biogenesis associated with prominent MYC transcriptional activity
Overall, we captured the transcriptional signatures of beta cell populations undergoing adaptive stress (without decompensation) and attenuation in association with significant beta cell proliferation (~20% of all beta cells) in obese female mice following acute leptin receptor KO
February 20, 2025 at 5:36 PM
Overall, we captured the transcriptional signatures of beta cell populations undergoing adaptive stress (without decompensation) and attenuation in association with significant beta cell proliferation (~20% of all beta cells) in obese female mice following acute leptin receptor KO
Obesity is the most potent physiologic stimulus to expand beta cells in both humans and pre-clinical models, representing a significant opportunity to identify relevant robust targets that translate to humans to expand and regenerate beta cells as replacement therapy in #T1D #T2D
February 20, 2025 at 5:36 PM
This was fun project not possible without my amazing co-authors: Dr. Sean Hartig animal studies, writing, support, mentorship; Peter Masschelin talented grad student at the time performed single cell analyses; Drs. Neil McKenna and Scott Ochsner for innovative bioinformatics tool
February 20, 2025 at 5:36 PM
This was fun project not possible without my amazing co-authors: Dr. Sean Hartig animal studies, writing, support, mentorship; Peter Masschelin talented grad student at the time performed single cell analyses; Drs. Neil McKenna and Scott Ochsner for innovative bioinformatics tool
Also shoutout to the amazing Dr. Kendra Carmon!
shorturl.at/7eBzT
shorturl.at/7eBzT
Women in Medicine & Sciences Feature: Kendra Carmon, PhD
This month's feature is Kendra Carmon, PhD, at the Brown Foundation Institute of Molecular Medicine's Center for Translational Cancer Research.
shorturl.at
February 13, 2025 at 11:45 PM
Also shoutout to the amazing Dr. Kendra Carmon!
shorturl.at/7eBzT
shorturl.at/7eBzT