A-TANGO Project
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a-tango.bsky.social
A-TANGO Project
@a-tango.bsky.social
A-TANGO, an EU-funded Horizon2020 research consortium, is conducting Phase II #clinical studies of an innovative therapeutic strategy called G-TAK to fight advanced #cirrhosis and acute-on-chronic #LiverFailure, aka #ACLF.

🌐 https://a-tango.eu
👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF!

#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
October 4, 2025 at 5:03 AM
For #WorldHepatitisDay we stand together 🩺

At A‑TANGO, we aim to transform healthcare for people with #LiverDisease, including those living with #cirrhosis and #ACLF, putting #patients first ☺️

Every person deserves timely, effective, and #stigma‑free support 💪

@europeliver.bsky.social
@who.int
July 28, 2025 at 4:17 PM
What an inspiring 9th Steering Committee Meeting! It was lovely to meet fellow liver-health enthusiasts & clinical investigators who recently joined the #GTAK Study. Let's include as many #ACLF patients in the study as possible.💉😊

#AlcoholicHepatitis

@europeliver.bsky.social
@easlnews.bsky.social
June 25, 2025 at 5:41 PM
Join this exciting event!

Don't miss our #OpenInnovation event, uniting experts in #DrugDevelopment, #bioinformatics, and #hepatology. Connect with researchers, industry professionals, and investors to share insights & explore collaboration opportunities!

🚀 Register now: inevent.uk/en/Crowdheli...
May 28, 2025 at 8:21 PM
📣 Secure your spot now 📣:
inevent.uk/en/Crowdheli...

Check out our upcoming (online) A-TANGO #LiverHealth Helix Event!

🟣 Industrial Perspective on #DrugDevelopment Challenges for #ClinicalTrials
🗓️ 04 June 2025
🕙 Begin: 10 am BST

#ClinicalResearch
@rajivjalan.bsky.social
@easlnews.bsky.social
May 20, 2025 at 1:49 PM
✅ How to reach a #consensus in science 🧬: Clinic director Frank Tacke (Charité) trains future #hepatology leaders on the #DelphiMethod, a reliable forecasting method using multiple rounds of questionnaires for an expert panel to reach a mutual agreement.

🗓️ What a fun #workshop at #EASLCongress 2025
May 12, 2025 at 6:35 AM
🧠 SAT-210 – #EASL2025

New tool alert!

The #mHEST scale brings clarity to grading hepatic #encephalopathy in trials & clinics. A big step for #cirrhosis care. Kudos to Prof. @rajivjalan.bsky.social & his team!

#LiverHealth #HE #ClinicalResearch
May 10, 2025 at 12:23 PM
🧪 SAT-209 – #EASL2025
MNK6106 vs. rifaximin to treat #HepaticEncephalopathy - new Phase 2a data from Prof. @rajivjalan.bsky.social (UCL) explores safety, PK & ammonia-lowering potential. HE treatment innovation in motion! #Cirrhosis
May 10, 2025 at 12:22 PM
👏 Fantastic job by Annarein Kerbert, LUMC, + Julian Pohl, Charité, at today's #networking session at #EASLCongress

👉 Is #alcohol-related #hepatitis in ACLF its own beast?
👉 Is systemic #inflammation the puppet master pulling #ACLF’s strings in booze-related hepatitis?

Chair @rajivjalan.bsky.social
May 10, 2025 at 10:41 AM
👑 The crown belongs to Julian Pohl for one of this year's TOP #Posters at #EASLCongress - Wow! 👏

🥳 TOP-217-YI 🥳

Pathophysiological basis of #ACLF triggered by #alcohol-related #hepatitis or #infection using circulating biomarkers of #inflammation, circulatory dysfunction & #albumin modifications
May 9, 2025 at 11:06 PM
Big crowd at the #ACLF & Critical Illness #PosterTour at #EASLCongress:

FRI-197
The AMMON-OHE model predicts #liver-related #complications in #outpatients with #cirrhosis: A prospective cohort study of the #AMMON consortium

Crucial for understanding the disease progression!
@rajivjalan.bsky.social
May 9, 2025 at 10:03 PM
🌟 POSTER THU-182 by Supachaya S. (UCL, @rajivjalan.bsky.social) featured in a #PosterTour at #EASLCongress! 👏

👉 Transcriptomic & metabolic insights into #hyperammonemia: The complementary therapeutic roles of #TLR4 inhibitor (#TAK242) + ornithine phenylacetate

👍 In A-TANGO, we use #TAK242 + G-CSF
May 9, 2025 at 3:05 PM
🎬 Summary #movie of A-TANGO's Investigator & Industry Session 🥂 at #EASLCongress. Big thanks to Yaqrit for sponsoring this inspiring event. Let's roll up our sleeves now to start the #GTAK trial in the UK, and hopefully also in India + Germany & other EU countries 🩺 ☺️!
#ACLF #cirrhosis #LiverFailure
May 8, 2025 at 10:10 PM
💲💰 Wake up your inner #entrepreneur, found your own start-up #company #business, and learn from expert @rajivjalan.bsky.social about how to manage financial conflicts of interest #COI

Today at #EASLCongress as part of a #YoungInvestigator Seminar!

📍 Erlinger Room
📅 Thurs, May 8
⏲️ 15:35 - 15:45 h
May 8, 2025 at 11:55 AM
📣 Today: #POSTER TOP-203, congrats 🥳

A rising international star is A-TANGO #YoungInvestigator Wenting Tan, UCL

👉 Recombinant insulin-like growth factor-1 #IGF1: a novel therapy for #patients with #cirrhosis + #ACLF

👉 Topic: Cirrhosis & Complications

#LiverFailure #ACLF
@rajivjalan.bsky.social
May 8, 2025 at 11:17 AM
📣 Another top-notch #poster at the very heart of A-TANGO is THU-180-YI by Supachaya Sriphoosanaphan, UCL

👉 #TLR4 inhibition restores cytochrome C oxidase mitigating #hyperammonemia-induced hepatocyte mitochondrial dysfunction

#Cirrhosis & Complications

#ACLF #LiverFailure
@rajivjalan.bsky.social
May 8, 2025 at 11:13 AM
📣 Two fantastic #posters today - visit them before 5 pm! Both by Supachaya Sriphoosanaphan, UCL

👉 THU-182
Transcriptomic and metabolic insights into #hyperammonemia: the complementary therapeutic roles of #TLR4 inhibitor and ornithine phenylacetate

👉 #Cirrhosis & Complications

#ACLF #LiverFailure
May 8, 2025 at 11:10 AM
May 8, 2025 at 8:28 AM
TODAY - catering provided🍎🥂 - just come by - still spots open, no registration needed ✅

A-TANGO #Investigator & #Industry Session
👉 Thurs, 8 May
👉 5-7 pm

at #EASLCongress

🚨 Important:
Access Room D202, Elicium Building (level 2), via bridge from main level

#ACLF #cirrhosis #LiverFailure #GTAK
May 8, 2025 at 8:18 AM
🎙️ Talking #ACLF with #patients!

The A-TANGO Layman Event at #EASL2025 hit the sweet spot between science & lived experience

🧪 New solutions via the combinatorial G-TAK therapy are on the horizon to achieve the best possible care for #LiverPatients

@europeliver.bsky.social
@rajivjalan.bsky.social
May 7, 2025 at 7:46 PM
👏 Our superstar Julian Pohl (Charité) is not only active in ACLF research but also brings 🧪 #suPAR & #MASLD into the spotlight! His poster WED-437 at #EASLCongress this year shows it can identify at-risk patients - a game-changer for non-invasive #diagnostics.

#LiverDisease #biomarkers #metabolism
May 7, 2025 at 10:29 AM
Hope for #ACLF patients is on the horizon!

Join the A-TANGO Patient Event at #EASLCongress:

📅 Wed, 7 May 2025
🕑 14:00–15:00
📍 Room D202, Elicium Building, Level 2

Learn about A-TANGO, the G-TAK trial and join the discussion on improving #patient outcomes.

#LiverDisease
@europeliver.bsky.social
April 25, 2025 at 7:02 PM
Let’s talk #inflammation, #alcohol-related #hepatitis and new treatment strategies at #EASLCongress

👉 A-TANGO Networking Session
🗓️ Sat, 10 May 2025, 9:45–10:15
📍 Cirrhosis & Complications Track Hub

These short networking sessions are lots of fun! @easlnews.bsky.social

#hepatology #cirrhosis #ACLF
April 25, 2025 at 6:48 PM
👉 Please register now:
docs.google.com/forms/d/e/1F...

Join us for the A-TANGO #Investigator & #Industry Session on Thursday, 8 May, from 5-7 pm at #EASLCongress. You can participate in person or online (Zoom Link will be set via email). #cirrhosis #LiverFailure #GTAK

✔️ Food & drinks provided 🥂
April 25, 2025 at 1:37 PM