3ehrendtLab
@3ehrendtlab.bsky.social
Nucleic Acid Immunity & Genome Defense
https://maps.app.goo.gl/cET4bEWpvKCp9KDM6
https://maps.app.goo.gl/cET4bEWpvKCp9KDM6
Do the authors claim that the RNA is sensed directly by cGAS and induced catalytic activity or is cGAS activation an indirect effect?
March 26, 2025 at 10:42 PM
Do the authors claim that the RNA is sensed directly by cGAS and induced catalytic activity or is cGAS activation an indirect effect?
Doesn‘t look all to flat there 🌍
#flatearth
#flatearth
March 20, 2025 at 1:44 PM
Doesn‘t look all to flat there 🌍
#flatearth
#flatearth
2/2
Together with colleagues from @immunosens.bsky.social we reviewed the role of cytosolic nucleic acid sensing in critical illness.
www.nature.com/articles/s41...
Together with colleagues from @immunosens.bsky.social we reviewed the role of cytosolic nucleic acid sensing in critical illness.
www.nature.com/articles/s41...
Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy
www.nature.com
March 19, 2025 at 5:45 PM
2/2
Together with colleagues from @immunosens.bsky.social we reviewed the role of cytosolic nucleic acid sensing in critical illness.
www.nature.com/articles/s41...
Together with colleagues from @immunosens.bsky.social we reviewed the role of cytosolic nucleic acid sensing in critical illness.
www.nature.com/articles/s41...
1/2
The ER membrane bound DNAse TREX1 prevents your own DNA from becoming viral mimicry. TREX1 can also move around in the cell, but it was unclear how. With collaborators @tudresden.bsky.social we identified TREX1 as a substrate for the intramembrane protease SPP.
link.springer.com/article/10.1...
The ER membrane bound DNAse TREX1 prevents your own DNA from becoming viral mimicry. TREX1 can also move around in the cell, but it was unclear how. With collaborators @tudresden.bsky.social we identified TREX1 as a substrate for the intramembrane protease SPP.
link.springer.com/article/10.1...
The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis - Cellular and Molecular Life Sciences
Signal peptide peptidase (SPP) is an ER-resident aspartyl intramembrane protease cleaving proteins within type II-oriented transmembrane segments. Here, we identified the tail-anchored protein Three p...
link.springer.com
March 19, 2025 at 5:45 PM
1/2
The ER membrane bound DNAse TREX1 prevents your own DNA from becoming viral mimicry. TREX1 can also move around in the cell, but it was unclear how. With collaborators @tudresden.bsky.social we identified TREX1 as a substrate for the intramembrane protease SPP.
link.springer.com/article/10.1...
The ER membrane bound DNAse TREX1 prevents your own DNA from becoming viral mimicry. TREX1 can also move around in the cell, but it was unclear how. With collaborators @tudresden.bsky.social we identified TREX1 as a substrate for the intramembrane protease SPP.
link.springer.com/article/10.1...