Wen Zhu Lab
@wenzhulab.bsky.social
Wen Zhu Lab @ Florida State University | Translational Enzymology & Drug Discovery | Student run account | www.wzhulab.com
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wzhulab.com
Passionate about enzyme structure, function, and dynamics, and applying that knowledge to drug discovery? 💊🧬🧫🧪 We’re recruiting a Postdoc!
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Official warm welcome to Sarai, a first year PhD student who joined our lab this semester 👩🔬😊
November 13, 2025 at 12:50 AM
Official warm welcome to Sarai, a first year PhD student who joined our lab this semester 👩🔬😊
We had a great time at the Tallahassee Science Festival today! The kids learned what an amino acid is and made a keychain or bracelet corresponding to the chemical formula of an amino acid.👩🔬🧑🔬
November 9, 2025 at 11:11 AM
We had a great time at the Tallahassee Science Festival today! The kids learned what an amino acid is and made a keychain or bracelet corresponding to the chemical formula of an amino acid.👩🔬🧑🔬
#RareDiseaseThursday Mutations in SMPD1 disrupt acid sphingomyelinase, leading to Niemann-Pick disease type A, a devastating lysosomal storage disorder. Lipids accumulate in cells, causing neurodegeneration, hepatosplenomegaly, and failure to thrive in infancy.
October 23, 2025 at 9:27 PM
#RareDiseaseThursday Mutations in SMPD1 disrupt acid sphingomyelinase, leading to Niemann-Pick disease type A, a devastating lysosomal storage disorder. Lipids accumulate in cells, causing neurodegeneration, hepatosplenomegaly, and failure to thrive in infancy.
Check out our latest preprint on an unexpected mechanism of a potent ASNS inhibitor: Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response www.biorxiv.org/content/10.1...
Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response
Targeting asparagine metabolism is a promising strategy for treating asparaginase-resistant acute lymphoblastic leukemia (ALL), sarcoma, and potentially other solid tumors. Here, we characterize the m...
www.biorxiv.org
October 17, 2025 at 7:36 PM
Check out our latest preprint on an unexpected mechanism of a potent ASNS inhibitor: Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress response www.biorxiv.org/content/10.1...
Passionate about enzyme structure, function, and dynamics, and applying that knowledge to drug discovery? 💊🧬🧫🧪 We’re recruiting a Postdoc!
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Contact — Wen Zhu Laboratory
Use this space to add a brief description of your project.
wzhulab.com
October 16, 2025 at 8:56 PM
Passionate about enzyme structure, function, and dynamics, and applying that knowledge to drug discovery? 💊🧬🧫🧪 We’re recruiting a Postdoc!
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Today in our #RareDiseaseThursday spotlight: Argininosuccinate synthetase deficiency (ASSD), a urea cycle disorder caused by pathogenic variants in ASS1, impairing the conversion of citrulline+aspartate to argininosuccinate. This leads to long-term neurological damage.
October 16, 2025 at 8:39 PM
Today in our #RareDiseaseThursday spotlight: Argininosuccinate synthetase deficiency (ASSD), a urea cycle disorder caused by pathogenic variants in ASS1, impairing the conversion of citrulline+aspartate to argininosuccinate. This leads to long-term neurological damage.
Our first group retreat at Clearwater, FL.
October 1, 2025 at 12:43 AM
Our first group retreat at Clearwater, FL.
Congrats Wen! 🎉🎉➡️FSU chemist earns $2.1 million NIH grant to investigate molecular causes of disease: news.fsu.edu/news/science...
FSU chemist earns $2.1 million NIH grant to investigate molecular causes of disease
A Florida State University researcher has received a multi-million-dollar grant to investigate the role enzymes — which influence nearly every process in
news.fsu.edu
September 17, 2025 at 7:26 PM
Congrats Wen! 🎉🎉➡️FSU chemist earns $2.1 million NIH grant to investigate molecular causes of disease: news.fsu.edu/news/science...
Succinate dehydrogenase (SDH) uniquely powers both the TCA cycle & electron transport chain. SDH mutations cause SDH deficiency, disrupting energy metabolism & leading to developmental delays. #RareDiseaseThursday
September 11, 2025 at 11:28 PM
Succinate dehydrogenase (SDH) uniquely powers both the TCA cycle & electron transport chain. SDH mutations cause SDH deficiency, disrupting energy metabolism & leading to developmental delays. #RareDiseaseThursday
KARS1 encodes lysyl-tRNA synthetase. Biallelic KARS mutations cause KARS syndrome, a severe disorder that affects multiple organs, particularly the nervous system. #RareDiseaseThursday
August 28, 2025 at 7:52 PM
KARS1 encodes lysyl-tRNA synthetase. Biallelic KARS mutations cause KARS syndrome, a severe disorder that affects multiple organs, particularly the nervous system. #RareDiseaseThursday
Congratulations to Julia and Adwaith for completing the 2025 Young Scholar Program and research symposium. It was a joy having you both in lab and we are very proud of you!
July 22, 2025 at 6:05 PM
Congratulations to Julia and Adwaith for completing the 2025 Young Scholar Program and research symposium. It was a joy having you both in lab and we are very proud of you!
Transaldolase deficiency is a rare metabolic disorder affecting the pentose phosphate pathway, leading to liver dysfunction, growth delays, and skin abnormalities. It’s caused by mutations in the TALDO1 gene. Early diagnosis is key to managing symptoms. #RareDiseaseThursday
July 3, 2025 at 9:39 PM
Transaldolase deficiency is a rare metabolic disorder affecting the pentose phosphate pathway, leading to liver dysfunction, growth delays, and skin abnormalities. It’s caused by mutations in the TALDO1 gene. Early diagnosis is key to managing symptoms. #RareDiseaseThursday
#RareDiseaseThursday Ribose-5-phosphate isomerase (RPI) deficiency is one of the rarest inborn errors of metabolism. Still no cure. It affects the pentose phosphate pathway, leading to impaired RNA synthesis or accumulation of D-ribitol and D-arabitol.
June 26, 2025 at 9:33 PM
#RareDiseaseThursday Ribose-5-phosphate isomerase (RPI) deficiency is one of the rarest inborn errors of metabolism. Still no cure. It affects the pentose phosphate pathway, leading to impaired RNA synthesis or accumulation of D-ribitol and D-arabitol.
Reposted by Wen Zhu Lab
🤔 What if classic probability puzzles could be encoded in chemistry? We mapped the Monty Hall problem into a deterministic chemical reaction network using mass-action kinetics. Curious? ... then check out our latest paper with
@wenzhulab.bsky.social in @pccp.rsc.org doi.org/10.1039/D5CP...
@wenzhulab.bsky.social in @pccp.rsc.org doi.org/10.1039/D5CP...
June 26, 2025 at 7:37 PM
🤔 What if classic probability puzzles could be encoded in chemistry? We mapped the Monty Hall problem into a deterministic chemical reaction network using mass-action kinetics. Curious? ... then check out our latest paper with
@wenzhulab.bsky.social in @pccp.rsc.org doi.org/10.1039/D5CP...
@wenzhulab.bsky.social in @pccp.rsc.org doi.org/10.1039/D5CP...
So excited that our work has already inspired one young girl to fall in love with science!
June 23, 2025 at 11:02 PM
So excited that our work has already inspired one young girl to fall in love with science!
Welcome to our #ColorMyMetalloE coloring series. This is an interactive adventure that brings the hidden world of metalloenzymes to life! You can also explore various existing careers as a chemist! Simply download the PDF, grab your favorite coloring tools, and let your creativity flow.
June 17, 2025 at 1:51 AM
Welcome to our #ColorMyMetalloE coloring series. This is an interactive adventure that brings the hidden world of metalloenzymes to life! You can also explore various existing careers as a chemist! Simply download the PDF, grab your favorite coloring tools, and let your creativity flow.
Wrapped up Zhu Lab’s 2nd Annual Undergraduate Researcher Appreciation Day with a sweet treat! 🍦 Thanks to our amazing young scholars, student mentors and neighboring labs for joining the ice cream social!
June 13, 2025 at 2:26 PM
Wrapped up Zhu Lab’s 2nd Annual Undergraduate Researcher Appreciation Day with a sweet treat! 🍦 Thanks to our amazing young scholars, student mentors and neighboring labs for joining the ice cream social!
On #RareDiseaseThursday, learn about Ribose-phosphate isomerase deficiency: an ultra-rare autosomal recessive disorder causing leukoencephalopathy, developmental delays, and spinocerebellar atrophy. Fewer than 10 cases known; metabolic testing matters!
June 6, 2025 at 1:50 AM
On #RareDiseaseThursday, learn about Ribose-phosphate isomerase deficiency: an ultra-rare autosomal recessive disorder causing leukoencephalopathy, developmental delays, and spinocerebellar atrophy. Fewer than 10 cases known; metabolic testing matters!
Fructose-1,6-bisphosphatase deficiency is a rare metabolic disorder characterized by impaired gluconeogenesis. Without this enzyme, the body can't maintain blood sugar, leading to hypoglycemia, lactic acidosis, and coma. #RareDiseaseThursday
May 29, 2025 at 10:21 PM
Fructose-1,6-bisphosphatase deficiency is a rare metabolic disorder characterized by impaired gluconeogenesis. Without this enzyme, the body can't maintain blood sugar, leading to hypoglycemia, lactic acidosis, and coma. #RareDiseaseThursday
#RareDiseaseThursday Mutations in glucose-6-phosphatase (G6Pase), an enzyme critical for glucose release, can lead to Von Gierke's Disease Type I. Dysfunctional G6Pase results in glycogen buildup in the liver and kidneys, leading to low blood sugar and organ damage
May 15, 2025 at 1:00 PM
#RareDiseaseThursday Mutations in glucose-6-phosphatase (G6Pase), an enzyme critical for glucose release, can lead to Von Gierke's Disease Type I. Dysfunctional G6Pase results in glycogen buildup in the liver and kidneys, leading to low blood sugar and organ damage
Today is a heartbreaking day. Our thoughts and deepest sympathies are with the victims and their families. It's time to put an end to gun violence on campuses!
April 17, 2025 at 10:40 PM
Today is a heartbreaking day. Our thoughts and deepest sympathies are with the victims and their families. It's time to put an end to gun violence on campuses!
We had several great presentations lately! Lucciano passed his second-year milestone talk. Jack presented at the FSU Undergraduate Research Symposium. Congrats!
April 13, 2025 at 1:05 AM
We had several great presentations lately! Lucciano passed his second-year milestone talk. Jack presented at the FSU Undergraduate Research Symposium. Congrats!
Congratulations to Caitlin Padgett on receiving the Honorable Mention in the NSF Graduate Research Fellowship Program! We're incredibly proud of your hard work and achievements! 🥳🥳🥳
April 8, 2025 at 4:14 PM
Congratulations to Caitlin Padgett on receiving the Honorable Mention in the NSF Graduate Research Fellowship Program! We're incredibly proud of your hard work and achievements! 🥳🥳🥳
Our latest review on #TBCK and #TBCKSyndrome is out now in Frontiers in Biophysics!! We look into the multi-domain architecture of the protein and its cellular function, shedding light on how mutations can lead to neurological disorders. #Raredisease www.frontiersin.org/journals/bio...
Frontiers | Decoding TBCK: from bioinformatic insights of domain architecture to disease implications
www.frontiersin.org
April 4, 2025 at 1:21 PM
Our latest review on #TBCK and #TBCKSyndrome is out now in Frontiers in Biophysics!! We look into the multi-domain architecture of the protein and its cellular function, shedding light on how mutations can lead to neurological disorders. #Raredisease www.frontiersin.org/journals/bio...
🖋️Hexosaminidase A deficiency leads to the devastating effects of Tay-Sachs disease, an autosomal recessive lysosomal storage disorder. Understanding this enzyme is key to advancing diagnosis and treatment options.🧠 #TaySachsDisease #RareDiseaseThursday
March 27, 2025 at 7:02 PM
🖋️Hexosaminidase A deficiency leads to the devastating effects of Tay-Sachs disease, an autosomal recessive lysosomal storage disorder. Understanding this enzyme is key to advancing diagnosis and treatment options.🧠 #TaySachsDisease #RareDiseaseThursday