Wennemers Group
@wennemersgroup.bsky.social
The Wennemers Group @ethzurich.bsky.social uses organic synthesis to tackle challenges in asymmetric catalysis, chemical biology, new synthetic materials and metal nanoparticles.
Student-run account. Posts by Helma signed HW.
www.wennemers.ethz.ch
Student-run account. Posts by Helma signed HW.
www.wennemers.ethz.ch
New from our group: proline-rich peptides that target mitochondria & stay there!
Tuning hydrophobicity and rigidity provided design rules for CPPs that enter cells and redistribute for long-term mitochondrial residency.
Now out in ACS Chemical Biology: pubs.acs.org/doi/10.1021/...
Tuning hydrophobicity and rigidity provided design rules for CPPs that enter cells and redistribute for long-term mitochondrial residency.
Now out in ACS Chemical Biology: pubs.acs.org/doi/10.1021/...
LinkedIn
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August 19, 2025 at 10:24 AM
New from our group: proline-rich peptides that target mitochondria & stay there!
Tuning hydrophobicity and rigidity provided design rules for CPPs that enter cells and redistribute for long-term mitochondrial residency.
Now out in ACS Chemical Biology: pubs.acs.org/doi/10.1021/...
Tuning hydrophobicity and rigidity provided design rules for CPPs that enter cells and redistribute for long-term mitochondrial residency.
Now out in ACS Chemical Biology: pubs.acs.org/doi/10.1021/...
Our senior scientist and Branco Weiss fellow, @tomfialab.bsky.social, is starting his own lab at Masaryk University. 👏 Check him out. So proud of you, Tom!
We have multiple PhD and Postdoc positions open in my new group at Masaryk University. Are you an excellent and motivated candidate interested in organic and peptide synthesis and chemical biology? Get in touch! Start in January 2026. www.fialalab.com
Appreciate sharing!
Appreciate sharing!
July 23, 2025 at 11:52 AM
Our senior scientist and Branco Weiss fellow, @tomfialab.bsky.social, is starting his own lab at Masaryk University. 👏 Check him out. So proud of you, Tom!
Congratulations to @tomfialab.bsky.social, who was awarded the @experientiacz.bsky.social start-up grant to start his independent research group at Masaryk University in Brno, Czechia with the project "Traceless Affinity Probes for Targeted Alteration of Proteoforms". Have a great start, Tom!
June 26, 2025 at 11:04 AM
Congratulations to @tomfialab.bsky.social, who was awarded the @experientiacz.bsky.social start-up grant to start his independent research group at Masaryk University in Brno, Czechia with the project "Traceless Affinity Probes for Targeted Alteration of Proteoforms". Have a great start, Tom!
🚨New paper from our group! A clever use of salt bridges to crack a tough problem in collagen heterotrimer design! Hyperstable, minimal-length, and blunt-ended heterotrimers - out in @angewandtechemie.bsky.social! Congrats to @tomfialab.bsky.social and everyone involved. Check it out: 🔗tin.al/IQej5
Selectively assembling collagen heterotrimers is a challenge. But not for us! Aminopropline-aspartate salt bridges drive the assembly of a hyperstable, a minimal-length, and a special blunt-ended collagen heterotrimer. Now out in
@angewandtechemie.bsky.social!
onlinelibrary.wiley.com/doi/10.1002/...
@angewandtechemie.bsky.social!
onlinelibrary.wiley.com/doi/10.1002/...
May 9, 2025 at 3:54 PM
🚨New paper from our group! A clever use of salt bridges to crack a tough problem in collagen heterotrimer design! Hyperstable, minimal-length, and blunt-ended heterotrimers - out in @angewandtechemie.bsky.social! Congrats to @tomfialab.bsky.social and everyone involved. Check it out: 🔗tin.al/IQej5
🚨 New preprint from our group! We report a photocatalytic, regiodivergent method to functionalize saturated N-heterocycles at the α- or β-position. The metal-free reaction runs in water with a flavin catalyst and gives rapid access to sought-after piperidines. Check it out here: 🔗 tin.al/DqxU
May 7, 2025 at 1:22 PM
🚨 New preprint from our group! We report a photocatalytic, regiodivergent method to functionalize saturated N-heterocycles at the α- or β-position. The metal-free reaction runs in water with a flavin catalyst and gives rapid access to sought-after piperidines. Check it out here: 🔗 tin.al/DqxU
Reposted by Wennemers Group
🚨 Happy to share a new preprint – our group’s first!
🔗 chemrxiv.org/engage/chemr...
We report a novel synthetic method to access cyclic ethers from diketones, powered by simple borane catalysts.
Thanks to the whole team for their excellent work!
🔗 chemrxiv.org/engage/chemr...
We report a novel synthetic method to access cyclic ethers from diketones, powered by simple borane catalysts.
Thanks to the whole team for their excellent work!
April 30, 2025 at 3:55 PM
🚨 Happy to share a new preprint – our group’s first!
🔗 chemrxiv.org/engage/chemr...
We report a novel synthetic method to access cyclic ethers from diketones, powered by simple borane catalysts.
Thanks to the whole team for their excellent work!
🔗 chemrxiv.org/engage/chemr...
We report a novel synthetic method to access cyclic ethers from diketones, powered by simple borane catalysts.
Thanks to the whole team for their excellent work!
Congratulations, Tobi!
🎉 Big day for our group: our first publication is out!
Tom did a fantastic job highlighting current trends & opportunities in peptide catalysis — now published in Chem Catalysis (open access). Huge congrats, Tom!
www.cell.com/chem-catalys...
Tom did a fantastic job highlighting current trends & opportunities in peptide catalysis — now published in Chem Catalysis (open access). Huge congrats, Tom!
www.cell.com/chem-catalys...
Peptide catalysis: Trends and opportunities
Peptides are highly selective organocatalysts, with intrinsic modularity allowing
precise control over structure and function. Advances in peptide synthesis, biotechnology,
and cheminformatics will en...
www.cell.com
April 26, 2025 at 6:55 AM
Congratulations, Tobi!
Chiral spirocyclic oxetanes & azetidines synthesized by organocatalytic additions to strained nitroolefins—a practical route to medicinally relevant molecules.
🔗 pubs.acs.org/doi/full/10....
🔗 pubs.acs.org/doi/full/10....
Enantioselective Conjugate Addition of Aldehydes to Oxetane- and Azetidine-Containing Nitroolefins: An Entry to Spirocyclic Pyrrolidines
Enantioselective amine-catalyzed conjugate additions of aldehydes to oxetane- and azetidine-containing nitroolefins afford γ-nitroaldehydes as key building blocks en route to spirocyclic oxetane/azetidine-pyrrolidines. The study provided insights into the stability and reactivity of these β,β-disubstituted nitroolefins and enabled the enantioselective synthesis of chiral oxetanes and azetidines in moderate-to-high yields and enantioselectivities. This approach expands synthetic access to medicinally relevant scaffolds and broadens the scope of enantioselective organocatalytic transformations.
pubs.acs.org
April 14, 2025 at 2:55 PM
Chiral spirocyclic oxetanes & azetidines synthesized by organocatalytic additions to strained nitroolefins—a practical route to medicinally relevant molecules.
🔗 pubs.acs.org/doi/full/10....
🔗 pubs.acs.org/doi/full/10....
Fluorescently labeled collagen model peptides are emerging as diagnostics for fibrosis and tissue repair. Our latest study highlights that careful selection of the fluorophore is essential when designing CMPs for such applications.
Now out in @angewandtechemie.bsky.social: tinyurl.com/4sbhdv95
Now out in @angewandtechemie.bsky.social: tinyurl.com/4sbhdv95
April 11, 2025 at 4:30 PM
Fluorescently labeled collagen model peptides are emerging as diagnostics for fibrosis and tissue repair. Our latest study highlights that careful selection of the fluorophore is essential when designing CMPs for such applications.
Now out in @angewandtechemie.bsky.social: tinyurl.com/4sbhdv95
Now out in @angewandtechemie.bsky.social: tinyurl.com/4sbhdv95