Wearn Xin (Edeline)
@wearnxin.bsky.social
Postdoc at UCSF // PhD at Oxford
Interested in pathogens, horizontal gene transfer and host-pathogen interactions :)
Interested in pathogens, horizontal gene transfer and host-pathogen interactions :)
Big thank you to @jbdsf.bsky.social and all our collaborators for this work! It's amazing how one nuclease can detect so many modifications!
Interested in phage defenses that natively block lytic phage used in therapies?
Or do you want to figure out if a phage has a modified genome?
Meet the END-nucleases, an enzyme family that can broadly restrict phages with many diverse modifications. From talented post-doc Wearn-Xin Yee!
Or do you want to figure out if a phage has a modified genome?
Meet the END-nucleases, an enzyme family that can broadly restrict phages with many diverse modifications. From talented post-doc Wearn-Xin Yee!
April 4, 2025 at 1:15 AM
Big thank you to @jbdsf.bsky.social and all our collaborators for this work! It's amazing how one nuclease can detect so many modifications!
We've identified a group of nucleases that can target multiple phages with hypermodified DNA, using a sensor domain present across many domains of life. We’ve even used this as a tool to find phages with hypermodified DNA! Really thankful to all the co-authors who have been such great help!
END nucleases: Antiphage defense systems targeting multiple hypermodified phage genomes
Prokaryotes carry clusters of phage defense systems in defense islands that have been extensively exploited bioinformatically and experimentally for discovery of immune functions. However, little effo...
www.biorxiv.org
April 2, 2025 at 4:39 PM
We've identified a group of nucleases that can target multiple phages with hypermodified DNA, using a sensor domain present across many domains of life. We’ve even used this as a tool to find phages with hypermodified DNA! Really thankful to all the co-authors who have been such great help!