Chanvillard et al. reveal that NNMT drives tubular senescence and fibrosis in early CKD. Through human data, spatial transcriptomics, and mouse, cell, and organoid models, they show that NNMT inhibition restores methylation balance and reverses senescence and fibrosis, therefore identifying NNMT as a promising therapeutic target for early CKD intervention.

npj Metabolic Health and Disease - The role of NAD+ metabolism and its modulation of mitochondria in aging and disease