Vascular Pharmacology
@vaspharma.bsky.social
Editors of Vascular Pharmacology
This is a journal of Vascular Biology and Medicine
https://www.sciencedirect.com/journal/vascular-pharmacology
This is a journal of Vascular Biology and Medicine
https://www.sciencedirect.com/journal/vascular-pharmacology
Pinned
Vascular Pharmacology is a journal of Vascular Biology and Medicine.
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
November 11, 2025 at 2:27 AM
New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC
Redirecting
doi.org
November 3, 2025 at 2:28 AM
Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC
New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 28, 2025 at 3:40 AM
New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
October 28, 2025 at 3:38 AM
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
October 23, 2025 at 2:49 AM
🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
October 23, 2025 at 2:48 AM
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension
October 22, 2025 at 7:49 AM
A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension
Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 22, 2025 at 7:48 AM
Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
October 22, 2025 at 7:43 AM
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 13, 2025 at 2:52 AM
Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists
More detials: www.sciencedirect.com/journal/vasc...
More detials: www.sciencedirect.com/journal/vasc...
October 12, 2025 at 5:03 AM
🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists
More detials: www.sciencedirect.com/journal/vasc...
More detials: www.sciencedirect.com/journal/vasc...
HOT OFF THE PRESS: CXCR4, a GPCR best known for roles in neuronal migration, is now observed on ependymal motile cilia. This is the first report linking CXCR4 to motile cilia in ependymal cells.
Find out more at doi.org/10.1016/j.vp...
Find out more at doi.org/10.1016/j.vp...
September 15, 2025 at 3:19 AM
HOT OFF THE PRESS: CXCR4, a GPCR best known for roles in neuronal migration, is now observed on ependymal motile cilia. This is the first report linking CXCR4 to motile cilia in ependymal cells.
Find out more at doi.org/10.1016/j.vp...
Find out more at doi.org/10.1016/j.vp...
New review highlights how perivascular progenitor cells act as reservoirs of mesenchymal stem cells, driving tissue repair, fibrosis, and regeneration—unlocking new paths for cell therapy, tissue engineering, and disease prediction
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
Mesenchymal progenitor cells in perivascular niches: forerunners of mesenchymal stem cells and players in tissue scarring and regeneration
The walls of all embryonic, foetal, and adult blood vessels contain mesodermal progenitors, distributed as pericytes in capillaries and micro vessels,…
www.sciencedirect.com
September 15, 2025 at 3:18 AM
New review highlights how perivascular progenitor cells act as reservoirs of mesenchymal stem cells, driving tissue repair, fibrosis, and regeneration—unlocking new paths for cell therapy, tissue engineering, and disease prediction
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
New study deciphers the genetics of chronic venous disease (CVD) using multi-omics! GWAS + eQTL + endothelial assays reveal key QTLs (VSTM2L, RPRD1B, SAMHD1, PNMA2) shaping vascular function & a diagnostic model with AUC = 0.898. A step toward precision biomarkers for CVD
#Genomics #VascularBiology
#Genomics #VascularBiology
September 9, 2025 at 3:59 AM
New study deciphers the genetics of chronic venous disease (CVD) using multi-omics! GWAS + eQTL + endothelial assays reveal key QTLs (VSTM2L, RPRD1B, SAMHD1, PNMA2) shaping vascular function & a diagnostic model with AUC = 0.898. A step toward precision biomarkers for CVD
#Genomics #VascularBiology
#Genomics #VascularBiology
New insights show how Drp1, a master regulator of mitochondrial fission, is controlled by multiple post-translational modifications. Targeting Drp1 may open promising therapeutic paths for restoring mitochondrial dynamics and protecting the heart.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 1, 2025 at 3:22 AM
New insights show how Drp1, a master regulator of mitochondrial fission, is controlled by multiple post-translational modifications. Targeting Drp1 may open promising therapeutic paths for restoring mitochondrial dynamics and protecting the heart.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Publication alert 🚨
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
August 29, 2025 at 7:29 AM
Publication alert 🚨
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
New insights on CTD-associated pulmonary arterial hypertension (CTD-PAH): an immune-driven, more aggressive form of PAH with worse survival than idiopathic PAH. Early combo therapy, close monitoring, and drugs like macitentan & selexipag show promise. #PAH #CTD #PulmonaryHypertension
August 29, 2025 at 7:27 AM
New insights on CTD-associated pulmonary arterial hypertension (CTD-PAH): an immune-driven, more aggressive form of PAH with worse survival than idiopathic PAH. Early combo therapy, close monitoring, and drugs like macitentan & selexipag show promise. #PAH #CTD #PulmonaryHypertension
New review highlights challenges in modeling doxorubicin (DOX)-induced cardiotoxicity across animal models. Acute vs chronic models, species differences, and missing comorbidities limit translation to humans. Key for advancing personalized cardio-oncology therapies.
#Cardiotoxicity #CardioOncology
#Cardiotoxicity #CardioOncology
August 29, 2025 at 7:14 AM
New review highlights challenges in modeling doxorubicin (DOX)-induced cardiotoxicity across animal models. Acute vs chronic models, species differences, and missing comorbidities limit translation to humans. Key for advancing personalized cardio-oncology therapies.
#Cardiotoxicity #CardioOncology
#Cardiotoxicity #CardioOncology
📢 Call for papers!
Special issue: Gene/Genome Editing in Cardiovascular Biology and Disease
Guest Editor: Joseph Miano, PhD
📆Deadline: 25 July 2026
❓Who is it for: Studies or reviews involving gene/genome editing in the cardiovascular system using cells, organoids, and animal models.
Special issue: Gene/Genome Editing in Cardiovascular Biology and Disease
Guest Editor: Joseph Miano, PhD
📆Deadline: 25 July 2026
❓Who is it for: Studies or reviews involving gene/genome editing in the cardiovascular system using cells, organoids, and animal models.
August 29, 2025 at 7:09 AM
📢 Call for papers!
Special issue: Gene/Genome Editing in Cardiovascular Biology and Disease
Guest Editor: Joseph Miano, PhD
📆Deadline: 25 July 2026
❓Who is it for: Studies or reviews involving gene/genome editing in the cardiovascular system using cells, organoids, and animal models.
Special issue: Gene/Genome Editing in Cardiovascular Biology and Disease
Guest Editor: Joseph Miano, PhD
📆Deadline: 25 July 2026
❓Who is it for: Studies or reviews involving gene/genome editing in the cardiovascular system using cells, organoids, and animal models.
single-cell RNA-seq reveals a shift toward pro-inflammatory M1 macrophages in abdominal aortic aneurysm (AAA), driven by STAT1 signaling. 10-gene inflammatory signature were developed that predicts prognosis & highlights potential therapeutic targets for AAA.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
August 25, 2025 at 12:03 PM
single-cell RNA-seq reveals a shift toward pro-inflammatory M1 macrophages in abdominal aortic aneurysm (AAA), driven by STAT1 signaling. 10-gene inflammatory signature were developed that predicts prognosis & highlights potential therapeutic targets for AAA.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Explore the cutting-edge of vascular disease research!
This special issue calls for papers on germline and somatic genomic and epigenomic alterations shaping vascular pathology. Submit insights on inherited and acquired changes driving diagnosis, therapy, and personalized medicine
#VascularGenomics
This special issue calls for papers on germline and somatic genomic and epigenomic alterations shaping vascular pathology. Submit insights on inherited and acquired changes driving diagnosis, therapy, and personalized medicine
#VascularGenomics
August 25, 2025 at 11:58 AM
Explore the cutting-edge of vascular disease research!
This special issue calls for papers on germline and somatic genomic and epigenomic alterations shaping vascular pathology. Submit insights on inherited and acquired changes driving diagnosis, therapy, and personalized medicine
#VascularGenomics
This special issue calls for papers on germline and somatic genomic and epigenomic alterations shaping vascular pathology. Submit insights on inherited and acquired changes driving diagnosis, therapy, and personalized medicine
#VascularGenomics
📢 Call for Papers!
Vascular Pharmacology special issue: Stem Cell & Organoids in Vascular Research
Guest Editors: Kai Wang, Yifei Miao
📅 Deadline: 15 May 2026
www.sciencedirect.com/special-issu...
Vascular Pharmacology special issue: Stem Cell & Organoids in Vascular Research
Guest Editors: Kai Wang, Yifei Miao
📅 Deadline: 15 May 2026
www.sciencedirect.com/special-issu...
August 25, 2025 at 11:56 AM
📢 Call for Papers!
Vascular Pharmacology special issue: Stem Cell & Organoids in Vascular Research
Guest Editors: Kai Wang, Yifei Miao
📅 Deadline: 15 May 2026
www.sciencedirect.com/special-issu...
Vascular Pharmacology special issue: Stem Cell & Organoids in Vascular Research
Guest Editors: Kai Wang, Yifei Miao
📅 Deadline: 15 May 2026
www.sciencedirect.com/special-issu...
Blocking C3aR cuts oxidative stress & MMP-2 activity in aortas of Ang II–treated hypertensive mice, without lowering BP. Highlights complement’s role in vascular damage, a potential new target in hypertension.
Link: www.sciencedirect.com/science/arti...
Link: www.sciencedirect.com/science/arti...
August 18, 2025 at 12:28 PM
Blocking C3aR cuts oxidative stress & MMP-2 activity in aortas of Ang II–treated hypertensive mice, without lowering BP. Highlights complement’s role in vascular damage, a potential new target in hypertension.
Link: www.sciencedirect.com/science/arti...
Link: www.sciencedirect.com/science/arti...
Unlock the future of heart health! The XXIV SIRC Congress spotlights new frontiers: immunoinflammation, mitochondrial dynamics, epigenetics, and COVID-19’s impact—driving more personalized, preventive cardiovascular care.
#CardioFrontiers #HeartResearch #Aging #Innovation
Author @enzolio.bsky.social
#CardioFrontiers #HeartResearch #Aging #Innovation
Author @enzolio.bsky.social
Exploring new cardiovascular frontiers: The Italian cardiovascular research landscape
www.sciencedirect.com
August 18, 2025 at 8:54 AM
Unlock the future of heart health! The XXIV SIRC Congress spotlights new frontiers: immunoinflammation, mitochondrial dynamics, epigenetics, and COVID-19’s impact—driving more personalized, preventive cardiovascular care.
#CardioFrontiers #HeartResearch #Aging #Innovation
Author @enzolio.bsky.social
#CardioFrontiers #HeartResearch #Aging #Innovation
Author @enzolio.bsky.social
Vascular Pharmacology is a journal of Vascular Biology and Medicine.
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
August 18, 2025 at 8:32 AM
Vascular Pharmacology is a journal of Vascular Biology and Medicine.
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹