Vascular Pharmacology
@vaspharma.bsky.social
Editors of Vascular Pharmacology
This is a journal of Vascular Biology and Medicine
https://www.sciencedirect.com/journal/vascular-pharmacology
This is a journal of Vascular Biology and Medicine
https://www.sciencedirect.com/journal/vascular-pharmacology
Pinned
Vascular Pharmacology is a journal of Vascular Biology and Medicine.
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
We're excited to connect with our community and share the latest updates, published articles, and upcoming activities.
Thank you for being part of our journey!👍🌹
A newly published systematic review & meta-analysis reveals that exercise pulmonary hypertension could be a promising endpoint for evaluating pharmacological therapies for chronic thromboembolic pulmonary disease without resting pulmonary hypertension.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
January 22, 2026 at 3:45 AM
A newly published systematic review & meta-analysis reveals that exercise pulmonary hypertension could be a promising endpoint for evaluating pharmacological therapies for chronic thromboembolic pulmonary disease without resting pulmonary hypertension.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Sotatercept has been found effective in PAH treatment. This review explores Sotatercept's pleiotropic benefits, particularly in erythropoiesis, muscle atrophy, and bone loss, and suggests how it could be transformative for PAH therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
January 15, 2026 at 2:41 AM
Sotatercept has been found effective in PAH treatment. This review explores Sotatercept's pleiotropic benefits, particularly in erythropoiesis, muscle atrophy, and bone loss, and suggests how it could be transformative for PAH therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Vascular smooth muscle cells are the underrated shapeshifters driving plaque evolution. Our new review unpacks how mechanics, molecular signals, and RNA regulation push vSMCs toward phenotypes that fuel plaque growth and vulnerability.
#Atherosclerosis #VascularBiology #SmoothMuscleCells
#Atherosclerosis #VascularBiology #SmoothMuscleCells
December 16, 2025 at 2:52 AM
Vascular smooth muscle cells are the underrated shapeshifters driving plaque evolution. Our new review unpacks how mechanics, molecular signals, and RNA regulation push vSMCs toward phenotypes that fuel plaque growth and vulnerability.
#Atherosclerosis #VascularBiology #SmoothMuscleCells
#Atherosclerosis #VascularBiology #SmoothMuscleCells
New Italian multicenter registry data reveal how pulmonary arterial hypertension (PAH) is diagnosed and treated in real life, early detection, comprehensive workups, and guideline-driven care. A sharper picture of patient needs.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
December 16, 2025 at 2:50 AM
New Italian multicenter registry data reveal how pulmonary arterial hypertension (PAH) is diagnosed and treated in real life, early detection, comprehensive workups, and guideline-driven care. A sharper picture of patient needs.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
#PAH #PulmonaryHypertension #RealWorldData #PHResearch #CardioScience'.
New study reveals that microplastics can worsen pulmonary hypertension by promoting EndMT, inflammation, and histone lactylation in endothelial cells. Key genes like TNFRSF11B and SGK1 emerge as potential therapeutic targets to counter PH progression.
#PulmonaryHypertension #EndMT #Microplastics
#PulmonaryHypertension #EndMT #Microplastics
December 9, 2025 at 2:30 AM
New study reveals that microplastics can worsen pulmonary hypertension by promoting EndMT, inflammation, and histone lactylation in endothelial cells. Key genes like TNFRSF11B and SGK1 emerge as potential therapeutic targets to counter PH progression.
#PulmonaryHypertension #EndMT #Microplastics
#PulmonaryHypertension #EndMT #Microplastics
New review explores amylin receptor agonists (AMYRAs) as next generation therapies for obesity, offering benefits that go beyond weight loss. With advances in AMYR biology, dual agonism, and delivery tech, AMYRAs may redefine precision obesity care by 2030.
#ObesityResearch #MetabolicHealth #Amylin
#ObesityResearch #MetabolicHealth #Amylin
December 9, 2025 at 2:28 AM
New review explores amylin receptor agonists (AMYRAs) as next generation therapies for obesity, offering benefits that go beyond weight loss. With advances in AMYR biology, dual agonism, and delivery tech, AMYRAs may redefine precision obesity care by 2030.
#ObesityResearch #MetabolicHealth #Amylin
#ObesityResearch #MetabolicHealth #Amylin
New review highlights how adaptive immunity shapes the development of aortic aneurysm and dissection (AAD) — from antigen activation to aortic damage. Understanding these immune pathways could unlock targeted therapies for this deadly condition.
#AorticDisease #Immunology #CardioResearch #AAD
#AorticDisease #Immunology #CardioResearch #AAD
December 9, 2025 at 2:20 AM
New review highlights how adaptive immunity shapes the development of aortic aneurysm and dissection (AAD) — from antigen activation to aortic damage. Understanding these immune pathways could unlock targeted therapies for this deadly condition.
#AorticDisease #Immunology #CardioResearch #AAD
#AorticDisease #Immunology #CardioResearch #AAD
New review: Nebivolol through NO-mediated vasodilation, shows promise in heart failure. Evidence highlights vascular, metabolic, and clinical benefits, with potential in personalized HF therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
December 5, 2025 at 8:22 AM
New review: Nebivolol through NO-mediated vasodilation, shows promise in heart failure. Evidence highlights vascular, metabolic, and clinical benefits, with potential in personalized HF therapy.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
November 11, 2025 at 2:27 AM
New study shows 17β-estradiol induces NOS-dependent vasorelaxation in mouse aorta, with subtle sex- differences among ER subtypes. PI3K inhibition enhances relaxation by reducing MLC phosphorylation.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC
Redirecting
doi.org
November 3, 2025 at 2:28 AM
Does vessel size truly dictate soluble guanylate cyclase sensitivity? A new commentary on Lubomirov et al. suggests enhanced cinaciguat responses in smaller arteries may reflect hypoxia–reoxygenation and pathological context, not intrinsic diameter effects. #vascularbiology #NOcGMP #sGC
New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 28, 2025 at 3:40 AM
New study: Reduced LMOD1 promotes smooth muscle cell proliferation and vascular lesion growth via CDK6 activation. Targeting CDK6 restores normal proliferation, revealing a reversible pathway in vascular remodeling.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
October 28, 2025 at 3:38 AM
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
October 23, 2025 at 2:49 AM
🚨New publication alert: GDF15 alleviates diabetic endothelial dysfunction & oxidative stress through AMPK-dependent pathways. A promising therapeutic target for vascular protection in diabetes
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
doi.org/10.1016/j.vp...
#GDF15 #Diabetes #EndothelialHealth #OxidativeStress #AMPK
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
October 23, 2025 at 2:48 AM
🚨New review explores how organ-on-chip especially endothelium-on-chip technology helps to unravel disease mechanisms tied to endothelial dysfunction. A game-changer for disease modeling, early detection & drug discovery.
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
#OrganOnChip #VascularBiology #Endothelium
doi.org/10.1016/j.vp...
A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension
October 22, 2025 at 7:49 AM
A systematic meta-analysis evaluates lorundrostat, a novel aldosterone synthase inhibitor, in patients with uncontrolled hypertension. The analysis suggests potential blood pressure–lowering effects, though further large-scale trials are needed to confirm long-term efficacy and safety #Hypertension
Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 22, 2025 at 7:48 AM
Our new review explores how targeting hypothalamic signaling may transform obesity care. GLP-1R agonists & next-gen peptides, such as AMG 133, show enhanced weight loss & metabolic effects.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
October 22, 2025 at 7:43 AM
New review highlights the Apelin/APJ pathway as a promising target in glioblastoma. By driving tumor angiogenesis, growth, and therapy resistance, Apelin could hold the key to more effective GBM treatments
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
doi.org/10.1016/j.vp...
#Glioblastoma #CancerResearch #NeuroOncology #Apelin #Angiogenesis
Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
October 13, 2025 at 2:52 AM
Atherosclerosis isn’t just about LDL, it’s also about leaky arteries. Our latest review explores emerging therapies that target transendothelial permeability, a promising, underexplored frontier in atherosclerosis.
doi.org/10.1016/j.vp...
doi.org/10.1016/j.vp...
🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists
More detials: www.sciencedirect.com/journal/vasc...
More detials: www.sciencedirect.com/journal/vasc...
October 12, 2025 at 5:03 AM
🎉Vascular Pharmacology Young Researcher Award 2025! Support emerging scientists—apply or nominate today! #VascularResearch #YoungScientists
More detials: www.sciencedirect.com/journal/vasc...
More detials: www.sciencedirect.com/journal/vasc...
HOT OFF THE PRESS: CXCR4, a GPCR best known for roles in neuronal migration, is now observed on ependymal motile cilia. This is the first report linking CXCR4 to motile cilia in ependymal cells.
Find out more at doi.org/10.1016/j.vp...
Find out more at doi.org/10.1016/j.vp...
September 15, 2025 at 3:19 AM
HOT OFF THE PRESS: CXCR4, a GPCR best known for roles in neuronal migration, is now observed on ependymal motile cilia. This is the first report linking CXCR4 to motile cilia in ependymal cells.
Find out more at doi.org/10.1016/j.vp...
Find out more at doi.org/10.1016/j.vp...
New review highlights how perivascular progenitor cells act as reservoirs of mesenchymal stem cells, driving tissue repair, fibrosis, and regeneration—unlocking new paths for cell therapy, tissue engineering, and disease prediction
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
Mesenchymal progenitor cells in perivascular niches: forerunners of mesenchymal stem cells and players in tissue scarring and regeneration
The walls of all embryonic, foetal, and adult blood vessels contain mesodermal progenitors, distributed as pericytes in capillaries and micro vessels,…
www.sciencedirect.com
September 15, 2025 at 3:18 AM
New review highlights how perivascular progenitor cells act as reservoirs of mesenchymal stem cells, driving tissue repair, fibrosis, and regeneration—unlocking new paths for cell therapy, tissue engineering, and disease prediction
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
#stemcells #tissueengineering #regenerativetherapy #vascularfibrosis
New study deciphers the genetics of chronic venous disease (CVD) using multi-omics! GWAS + eQTL + endothelial assays reveal key QTLs (VSTM2L, RPRD1B, SAMHD1, PNMA2) shaping vascular function & a diagnostic model with AUC = 0.898. A step toward precision biomarkers for CVD
#Genomics #VascularBiology
#Genomics #VascularBiology
September 9, 2025 at 3:59 AM
New study deciphers the genetics of chronic venous disease (CVD) using multi-omics! GWAS + eQTL + endothelial assays reveal key QTLs (VSTM2L, RPRD1B, SAMHD1, PNMA2) shaping vascular function & a diagnostic model with AUC = 0.898. A step toward precision biomarkers for CVD
#Genomics #VascularBiology
#Genomics #VascularBiology
New insights show how Drp1, a master regulator of mitochondrial fission, is controlled by multiple post-translational modifications. Targeting Drp1 may open promising therapeutic paths for restoring mitochondrial dynamics and protecting the heart.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 1, 2025 at 3:22 AM
New insights show how Drp1, a master regulator of mitochondrial fission, is controlled by multiple post-translational modifications. Targeting Drp1 may open promising therapeutic paths for restoring mitochondrial dynamics and protecting the heart.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Publication alert 🚨
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
August 29, 2025 at 7:29 AM
Publication alert 🚨
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
New study shows Sodium-glucose cotransporter 2 inhibition by canagliflozin boosts testicular microvascular function & vascular signaling in a swine model of metabolic syndrome & ischemic cardiomyopathy. Highlights vasoprotective effects beyond the heart.
#MicrovascularHealth
New insights on CTD-associated pulmonary arterial hypertension (CTD-PAH): an immune-driven, more aggressive form of PAH with worse survival than idiopathic PAH. Early combo therapy, close monitoring, and drugs like macitentan & selexipag show promise. #PAH #CTD #PulmonaryHypertension
August 29, 2025 at 7:27 AM
New insights on CTD-associated pulmonary arterial hypertension (CTD-PAH): an immune-driven, more aggressive form of PAH with worse survival than idiopathic PAH. Early combo therapy, close monitoring, and drugs like macitentan & selexipag show promise. #PAH #CTD #PulmonaryHypertension