The Vallee Foundation
@valleefoundation.bsky.social
To promote a collegial community of international scientists, to enhance scientific collaboration and communication, and to advance medical education and biomedical research.
And Vallee Scholar Michael Yartsev is discovering how bats learn, remember and form social bonds:
www.hhmi.org/news/bat-res...
www.hhmi.org/news/bat-res...
How Bat Research Sheds Light on the Brain and Behavior | HHMI
HHMI scientists Michael Yartsev and Gerald Carter are uncovering how bats learn, remember, and form social bonds — findings that could reshape how we understand our own brains and behaviors.
www.hhmi.org
November 3, 2025 at 8:29 PM
And Vallee Scholar Michael Yartsev is discovering how bats learn, remember and form social bonds:
www.hhmi.org/news/bat-res...
www.hhmi.org/news/bat-res...
Two new papers from Vallee Scholar Johannes Gräff on memory consolidation:
www.nature.com/articles/s41...
onlinelibrary.wiley.com/doi/epdf/10....
www.nature.com/articles/s41...
onlinelibrary.wiley.com/doi/epdf/10....
Cell-type- and locus-specific epigenetic editing of memory expression - Nature Genetics
CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.
www.nature.com
November 3, 2025 at 8:27 PM
Two new papers from Vallee Scholar Johannes Gräff on memory consolidation:
www.nature.com/articles/s41...
onlinelibrary.wiley.com/doi/epdf/10....
www.nature.com/articles/s41...
onlinelibrary.wiley.com/doi/epdf/10....
and from Vallee Scholar Mackenzie Mathis: www.cell.com/cell/fulltex...
Decoding the brain: From neural representations to mechanistic models
Understanding how the brain works has been a formidable challenge in neuroscience,
but advances at the computational level are now driving us closer. This perspective
discusses core concepts of neural...
www.cell.com
October 17, 2025 at 3:45 PM
and from Vallee Scholar Mackenzie Mathis: www.cell.com/cell/fulltex...
Interesting study from Vallee Scholar Melissa Harrison: medicalxpress.com/news/2025-10...
Fruit fly study reveals genetic targets for rare childhood brain cancer treatment
Using fruit flies, University of Wisconsin–Madison researchers have developed a new model for investigating the genetic drivers of a rare but aggressive brain tumor in children. The work has already i...
medicalxpress.com
October 17, 2025 at 3:44 PM
Interesting study from Vallee Scholar Melissa Harrison: medicalxpress.com/news/2025-10...
Vallee Scholar Lisa Giocomo reveals how aging affects special memory news.ssbcrack.com/study-reveal...
Study Reveals How Aging Affects Spatial Memory in Mice - SSBCrack News
In a groundbreaking study, researchers at Stanford Medicine have discovered critical insights into how spatial memory declines with aging, revealing potential
news.ssbcrack.com
October 7, 2025 at 7:08 PM
Vallee Scholar Lisa Giocomo reveals how aging affects special memory news.ssbcrack.com/study-reveal...
Vallee Scholar Daniel Jarosz becomes first senior associate dean for basic science at Stanford University. med.stanford.edu/news/all-new...
Dan Jarosz becomes first senior associate dean for basic science
Jarosz is the inaugural appointment to the newly created position, which will support basic science faculty throughout the Stanford School of Medicine.
med.stanford.edu
October 7, 2025 at 7:05 PM
Vallee Scholar Daniel Jarosz becomes first senior associate dean for basic science at Stanford University. med.stanford.edu/news/all-new...
Vallee Scholar Madeline Lancaster appointed Joint Head of the Cell Biology Division at MRC Laboratory of Molecular Biology in Cambridge:
www2.mrc-lmb.cam.ac.uk/madeline-lan...
www2.mrc-lmb.cam.ac.uk/madeline-lan...
Madeline Lancaster appointed Joint Head of the Cell Biology Division - MRC Laboratory of Molecular Biology
Group Leader Madeline Lancaster joins Manu Hegde to oversee the LMB’s Cell Biology Division.
www2.mrc-lmb.cam.ac.uk
October 7, 2025 at 7:04 PM
Vallee Scholar Madeline Lancaster appointed Joint Head of the Cell Biology Division at MRC Laboratory of Molecular Biology in Cambridge:
www2.mrc-lmb.cam.ac.uk/madeline-lan...
www2.mrc-lmb.cam.ac.uk/madeline-lan...
Vallee scholar Rickard Sandberg, professor of Molecular Genetics, member of the Nobel Committee, is interviewed by Sharon Jåma about this year's Nobel prize.
www.youtube.com/watch?v=5fxn...
www.youtube.com/watch?v=5fxn...
“A fundamental discovery about the principle that keeps our immune system in check” | Medicine prize
YouTube video by Nobel Prize
www.youtube.com
October 7, 2025 at 7:02 PM
Vallee scholar Rickard Sandberg, professor of Molecular Genetics, member of the Nobel Committee, is interviewed by Sharon Jåma about this year's Nobel prize.
www.youtube.com/watch?v=5fxn...
www.youtube.com/watch?v=5fxn...
Vallee Scholar Weizhe Hong has a new paper out in Nature which shows a remarkable convergence of neuroscience and artificial intelligence: www.eurekalert.org/news-release...
First-of-its-kind study finds striking parallels between biological and artificial intelligence during social interaction
A first-of-its-kind study reveals that when mice interact socially, specific brain cell types synchronize in "shared neural spaces," and AI agents develop analogous patterns when engagi...
www.eurekalert.org
July 3, 2025 at 7:32 PM
Vallee Scholar Weizhe Hong has a new paper out in Nature which shows a remarkable convergence of neuroscience and artificial intelligence: www.eurekalert.org/news-release...
Vallee Scholar Bob Datta is on Instagram with an important message about Alzheimer's research
www.instagram.com/reel/DKzuKjR...
www.instagram.com/reel/DKzuKjR...
June 19, 2025 at 3:21 PM
Vallee Scholar Bob Datta is on Instagram with an important message about Alzheimer's research
www.instagram.com/reel/DKzuKjR...
www.instagram.com/reel/DKzuKjR...
Congratulations to Vallee Fdtn Director Wade Harper (HMS) on $5M+ Fox Fdtn grant for PD research & collab with VVPs Brenda Schulman, Ulrich Hartl (MPI), Judith Frydman (Stanford) among others in international, multidisciplinary Collaborative Research Network (CRN)
hms.harvard.edu/departments/...
hms.harvard.edu/departments/...
hms.harvard.edu
June 9, 2025 at 4:15 PM
Congratulations to Vallee Fdtn Director Wade Harper (HMS) on $5M+ Fox Fdtn grant for PD research & collab with VVPs Brenda Schulman, Ulrich Hartl (MPI), Judith Frydman (Stanford) among others in international, multidisciplinary Collaborative Research Network (CRN)
hms.harvard.edu/departments/...
hms.harvard.edu/departments/...
Many congratulations to Vallee Scholar Tanmay Bharat, Group Leader in the MRC Lab of Molecular Biology, who has been awarded the EMBO Gold Medal for his research in the field of structural microbiology! www2.mrc-lmb.cam.ac.uk/tanmay-bhara...
Tanmay Bharat awarded EMBO Gold Medal - MRC Laboratory of Molecular Biology
Tanmay Bharat, Group Leader in the LMB’s Structural Studies Division, received EMBO’s Gold Medal in recognition of his work on prokaryotic surface molecules.
www2.mrc-lmb.cam.ac.uk
June 5, 2025 at 7:27 PM
Many congratulations to Vallee Scholar Tanmay Bharat, Group Leader in the MRC Lab of Molecular Biology, who has been awarded the EMBO Gold Medal for his research in the field of structural microbiology! www2.mrc-lmb.cam.ac.uk/tanmay-bhara...
Congratulations to Dr Danelle Devenport (Vallee Scholar 2014), Shirley M. Tilghman Professor of Molecular Biology at Princeton U, who received the President's Award for Distinguished Teaching at Commencement ceremonies on Tuesday, May 27
www.princeton.edu/news/2025/05...
www.princeton.edu/news/2025/05...
Faculty members receive President’s Awards for Distinguished Teaching
Professors Rebecca Carey, Gabriel Crouch, Danelle Devenport and Nathaniel Fisch received the President’s Award for Distinguished Teaching at Commencement ceremonies May 27.
www.princeton.edu
May 28, 2025 at 6:56 PM
Congratulations to Dr Danelle Devenport (Vallee Scholar 2014), Shirley M. Tilghman Professor of Molecular Biology at Princeton U, who received the President's Award for Distinguished Teaching at Commencement ceremonies on Tuesday, May 27
www.princeton.edu/news/2025/05...
www.princeton.edu/news/2025/05...
So happy for our Vallee Visiting Professor Wolfang Baumeister who has just been named the Shaw Prize in Life Science and Medicine: erc.europa.eu/news-events/...
ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
erc.europa.eu
May 28, 2025 at 1:38 PM
So happy for our Vallee Visiting Professor Wolfang Baumeister who has just been named the Shaw Prize in Life Science and Medicine: erc.europa.eu/news-events/...
Research teams working with Tyler Jacks (VVP 2016) (MIT) and William Freed-Pastor (Dana-Farber and MIT) have a new article in Science in which they show how a class of proteins expressed in pancreatic cancer cells, could serve as targets for immune cell therapy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition
Translation of the noncoding genome in cancer can generate cryptic (noncanonical) peptides capable of presentation by human leukocyte antigen class I (HLA-I); however, the cancer specificity and immun...
www.science.org
May 16, 2025 at 7:52 PM
Research teams working with Tyler Jacks (VVP 2016) (MIT) and William Freed-Pastor (Dana-Farber and MIT) have a new article in Science in which they show how a class of proteins expressed in pancreatic cancer cells, could serve as targets for immune cell therapy.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Feng Zhang (Vallee Scholar 2013) and his team at the McGovern and Broad Institutes have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. See their paper in Nature Biotch
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Evolution-guided protein design of IscB for persistent epigenome editing in vivo - Nature Biotechnology
A combination of engineering approaches is used to improve the function of IscB for a variety of editing activities in vivo.
www.nature.com
May 16, 2025 at 7:50 PM
Feng Zhang (Vallee Scholar 2013) and his team at the McGovern and Broad Institutes have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. See their paper in Nature Biotch
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Elena Conti, PhD (Vallee Visiting Prof 2019), Director, MPI of Biochemistry in Martinsried, shares this year’s prestigious Jung Prize for Medicine with Jorn Piel, MD, ETH Zurich.
thevalleefoundation.org/news/elena-c...
thevalleefoundation.org/news/elena-c...
Elena Conti wins Jung Prize for Medicine | The Vallee Foundation
thevalleefoundation.org
May 16, 2025 at 7:48 PM
Elena Conti, PhD (Vallee Visiting Prof 2019), Director, MPI of Biochemistry in Martinsried, shares this year’s prestigious Jung Prize for Medicine with Jorn Piel, MD, ETH Zurich.
thevalleefoundation.org/news/elena-c...
thevalleefoundation.org/news/elena-c...
Congratulations to Feng Zhang (Vallee Scholar 2013) (Broad Inst, MIT, HHMI Investigator) who received an honorary doctorate from Duke University on Sunday!
today.duke.edu/2025/04/duke...
today.duke.edu/2025/04/duke...
Duke to Award Three Honorary Degrees at 2025 Commencement Ceremony | Duke Today
today.duke.edu
May 13, 2025 at 1:46 PM
Congratulations to Feng Zhang (Vallee Scholar 2013) (Broad Inst, MIT, HHMI Investigator) who received an honorary doctorate from Duke University on Sunday!
today.duke.edu/2025/04/duke...
today.duke.edu/2025/04/duke...
Chris Mason (Vallee Scholar 2014) at Weil Cornell Medicine is one of the PIs seeking to catalog the normal human virome, the immense ecosystem of viruses that lives in and on us.
news.weill.cornell.edu/news/2025/04...
news.weill.cornell.edu/news/2025/04...
A VAST New View of Viruses
A major new effort at Weill Cornell Medicine seeks to catalog the normal human virome, the immense ecosystem of viruses that lives in and on us.
news.weill.cornell.edu
April 28, 2025 at 3:05 PM
Chris Mason (Vallee Scholar 2014) at Weil Cornell Medicine is one of the PIs seeking to catalog the normal human virome, the immense ecosystem of viruses that lives in and on us.
news.weill.cornell.edu/news/2025/04...
news.weill.cornell.edu/news/2025/04...
Vallee Scholar (2021) Ricardo Mallarino (Princeton) has been using the sugar glider (Petaurus breviceps) to investigate immunological defense strategies. Check out his recent paper in Science
www.science.org/doi/10.1126/....
www.science.org/doi/10.1126/....
Cathelicidin antimicrobial peptides mediate immune protection in marsupial neonates
Cathelicidin antimicrobial peptides protect marsupial neonates by mediating immune defense against pathogens.
www.science.org
April 17, 2025 at 3:24 PM
Vallee Scholar (2021) Ricardo Mallarino (Princeton) has been using the sugar glider (Petaurus breviceps) to investigate immunological defense strategies. Check out his recent paper in Science
www.science.org/doi/10.1126/....
www.science.org/doi/10.1126/....
Reposted by The Vallee Foundation
Excited to share our exploration @naturemethods.bsky.social into new horizons opening up in the era of low cost sequencing!
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Imagination and new opportunities go ⏫
@landau.bsky.social
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the
@UltimaGenomics
platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling
Nature Methods - This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.
rdcu.be
April 11, 2025 at 4:41 PM
Excited to share our exploration @naturemethods.bsky.social into new horizons opening up in the era of low cost sequencing!
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
Reposted by The Vallee Foundation
Join us at the Royal Society in London 14 November for a day on Ancient genomes, human biology and medicine!
Many slots are reserved for talks from submitted abstracts related to the topic, alongside speakers Svante Pääbo, Priya Moorjani, @mathiesoniain.bsky.social and Lluis Quintana-Murci.
Many slots are reserved for talks from submitted abstracts related to the topic, alongside speakers Svante Pääbo, Priya Moorjani, @mathiesoniain.bsky.social and Lluis Quintana-Murci.
Registration now open! Join us for our Autumn Meeting:
“Ancient genomes: perspectives on human biology and medicine” organised by @janetk.bsky.social and @pontus-skoglund.bsky.social.
Explore how ancient DNA informs migration, adaptation & disease.
genetics.org.uk/events/ancie...
“Ancient genomes: perspectives on human biology and medicine” organised by @janetk.bsky.social and @pontus-skoglund.bsky.social.
Explore how ancient DNA informs migration, adaptation & disease.
genetics.org.uk/events/ancie...
April 14, 2025 at 12:23 PM
Join us at the Royal Society in London 14 November for a day on Ancient genomes, human biology and medicine!
Many slots are reserved for talks from submitted abstracts related to the topic, alongside speakers Svante Pääbo, Priya Moorjani, @mathiesoniain.bsky.social and Lluis Quintana-Murci.
Many slots are reserved for talks from submitted abstracts related to the topic, alongside speakers Svante Pääbo, Priya Moorjani, @mathiesoniain.bsky.social and Lluis Quintana-Murci.
Reposted by The Vallee Foundation
Abstract submissions for short talks are still opened until April 20th for the EMBO Escrt meeting 2025. There are plenty of options for short talks, please apply online at meetings.embo.org/event/25-escrt
ESCRT function, evolutionary diversity and mechanism of action
The ESCRTs (Endosomal Sorting Complexes Required for Transport) were discovered in 2002 and became one of the most dynamic fields of research in membrane cell biology. ESCRTs are protein complexes fo…
meetings.embo.org
April 14, 2025 at 1:15 PM
Abstract submissions for short talks are still opened until April 20th for the EMBO Escrt meeting 2025. There are plenty of options for short talks, please apply online at meetings.embo.org/event/25-escrt
Tanmay Bharat (Vallee Scholar 2018) has been working with colleagues at Brandeis University and the Max Planck Institute for Biology, Tubingen, on The Role of Mechanical Forces in Multicellularity:
When the pressure is on, Archaea go multicellular
Mechanical compression induces multicellular organization in archaea
www.mpg.de
April 11, 2025 at 4:33 PM
Tanmay Bharat (Vallee Scholar 2018) has been working with colleagues at Brandeis University and the Max Planck Institute for Biology, Tubingen, on The Role of Mechanical Forces in Multicellularity:
New paper from Vallee Scholar (2018) Sichen (Susan) Shao in Science: www.science.org/doi/10.1126/...
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution
ARMC1 partitions between distinct outer mitochondrial membrane complexes and the cytosol to control mitochondrial distribution.
www.science.org
April 11, 2025 at 4:28 PM
New paper from Vallee Scholar (2018) Sichen (Susan) Shao in Science: www.science.org/doi/10.1126/...