The Twinkle Factory
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twinklefactory.bsky.social
The Twinkle Factory
@twinklefactory.bsky.social
Crazy of fluorescent protein labels, dimerizers, biosensors, etc. The place for #FAST, #splitFAST, #CATCHFIRE, more to come
🔬🌈 #CATCHFIRE now implemented in neurogenesis studies!

🔬🌈 Check www.nature.com/articles/s41467-025-66932-0
December 18, 2025 at 1:26 PM
🔬🌈 Into #neurogenesis studies?

🔬🌈 Just out in Nature Communications! With #CATCHFIRE, the fluorogenic dimerizer of The Twinkle Factory, the authors were indeed able to force the displacement of mitochondria towards microtubules during mitosis

www.nature.com/articles/s41...
Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis - Nature Communications
Bunel et al. show that mitochondria behave as asymmetric fate determinants in vertebrates in vivo. Forcing their unequal segregation during mitosis is sufficient to drive premature neural differentiat...
www.nature.com
December 18, 2025 at 1:22 PM
Reposted by The Twinkle Factory
New biosensor for REDOX lovers! Scientists at VIB, Daria Ezeriņa and Joris Messens, with global partners, developed HyPerFLEX🌈!

@messenslab.bsky.social
October 17, 2025 at 3:11 PM
🌈 #CATCHFIRE unexpectedly used to track protein excretion by B. subtilis

🌈 in J. Agric. Food Chem. pubs.acs.org/doi/10.1021/acs.jafc.5c05062
December 5, 2025 at 10:45 PM
🌈 #CATCHFIRE now applied to force mitochondria displacement during mitosis and drive premature neuronal differentiation

🌈 preprint: www.biorxiv.org/content/10.1101/2024.11.08.622699v2
December 5, 2025 at 10:30 PM
🌈 into H2O2 sensing? Check this paper on HyPerFLEX, an upgrade of the famous Hyper sensor family, combined with #FAST of The Twinkle Factory (@twinklefactory.bsky.social)
🌈 www.nature.com/articles/s41...
A color-tailored fluorogenic sensor for hydrogen peroxide - Nature Chemical Biology
Hydrogen peroxide is a signaling molecule that can also cause damage if its levels are too high. Here, the authors report HyPerFLEX, a fluorescent sensor with tenable colors, to track very low peroxid...
www.nature.com
December 5, 2025 at 7:48 PM
🌈 a thorough review on fluorescent biosensors. Thxs!
🌈 many occurrences of FAST and splitFAST of The Twinkle Factory (@twinklefactory.bsky.social)
🚨How do we implement synthetic fluorophores into biosensors? Have a look at Elias Dressler’s review article in Chimia. The issue highlights the work of Young Professors and Ambizione Fellows in Switzerland. Glad to be part of this vibrant community. ⚗️ www.chimia.ch/chimia/artic...
November 28, 2025 at 3:52 PM