Tae-Kyeong Jeong
@tkjeong.bsky.social
Reposted by Tae-Kyeong Jeong
Cells control the supply of new histones to chromatin by blocking histone chaperone function - see here how Codanin-1 sequesters 4 ASF1 molecules.
𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇
CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply
Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...
rdcu.be
March 23, 2025 at 12:04 PM
Cells control the supply of new histones to chromatin by blocking histone chaperone function - see here how Codanin-1 sequesters 4 ASF1 molecules.
Brilliant summaries from our wonderful collaborator @grothlab.bsky.social . I'm always grateful for your enthusiasm, and I hope the next chapter of our story!
𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇
CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply
Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...
rdcu.be
March 7, 2025 at 4:30 PM
Brilliant summaries from our wonderful collaborator @grothlab.bsky.social . I'm always grateful for your enthusiasm, and I hope the next chapter of our story!
I'm delighted to share that our paper has been published in Nature Communications. I am deeply grateful to our passionate mentor, @jijoonsong.bsky.social as well as the fantastic collaborators, @groth-anja.bsky.social and @ciaranfrater.bsky.social !!
CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply - Nature Communications
CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A complex, showing that CODANIN-1 u...
www.nature.com
March 7, 2025 at 4:21 PM
I'm delighted to share that our paper has been published in Nature Communications. I am deeply grateful to our passionate mentor, @jijoonsong.bsky.social as well as the fantastic collaborators, @groth-anja.bsky.social and @ciaranfrater.bsky.social !!