Congrats to Ella for her new paper! She asked a really interesting question about how the brain represents uncertainty during hidden state inference, and in a lovely crossover with theoretical work, she shows that in mice, acetylcholine dynamics play a crucial role. www.biorxiv.org/content/10.1...

This work is now out in Nature Communications! 🎉

Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry: www.nature.com/articles/s41467-025-64702-6

Huge thanks to our amazing team! @beckyneuro.bsky.social @campsydept.bsky.social @camneuro.bsky.social

Long overdue update prompted by submitting my hardbound thesis: I successfully defended my PhD earlier this year and have started a postdoc with @beckyneuro.bsky.social! Excited for more adventures in uncertainty with an amazing team.

Mental and metabolic health are closely linked - but what drives this connection? In our new theory paper, we (w/ @camillanord.bsky.social & @hugofleming.bsky.social g.bsky.social) propose dysregulation of interoceptive energy allostasis as a key mechanism.
www.science.org/doi/10.1126/... 🧵 1/n

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level).

If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

so, so excited to share our new theory which endeavours to answer why depression and poor metabolic health go hand-in-hand: "An interoceptive model of energy allostasis linking metabolic and mental health" 💪🧠🔋 @saramehrhof.bsky.social
@hugofleming.bsky.social

osf.io/preprints/ps...