The Lancet Psychiatry
@thelancetpsych.bsky.social
The Lancet Psychiatry publishes original research to advance psychiatric practice, covering topics like #psychopharmacology, #psychotherapy, and #psychosocial approaches.
🌐 https://www.thelancet.com/journals/lanpsy/home
The Lancet Psychiatry is a peer-reviewed scientific journal published by Elsevier. It is a speciality journal of The Lancet.
Source: Wikipedia
Psychology
44%
Public Health
18%
The global epidemiology of personality disorder: a systematic review and meta-regression
Personality disorder is common, associated with premature mortality, and diagnostically
stable, yet remains excluded from the Global Burden of Diseases, Injuries, and Risk
Factors Study. We provide a ...
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"This study highlights the importance of the inclusion of pesonality disorder in global health frameworks, such as the [...] GBD Study. Our findings lay the groundwork for integrating personality disorder into future iterations of GBD."
New research article:
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New research article:
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Transdiagnostic effectiveness and safety of clozapine in individuals with psychotic, affective, and personality disorders: nationwide and meta-analytic comparisons with other antipsychotics
These findings support the transdiagnostic effectiveness and safety of clozapine,
particularly in schizophrenia-spectrum disorders, bipolar disorder, and severe depression.
Given the overall consisten...
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"clozapine is more effective than other oral antipsychotics in reducing psychiatric hospitalisations and several secondary outcomes in schizophrenia-spectrum disorders, bipolar disorder, inpatient-treated major depressive disorder, & psychotic depression"
Article:
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Article:
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Clinical management of major depressive disorder with comorbid obesity
Obesity is one of the most prevalent somatic comorbidities in individuals with major
depressive disorder and greatly affects the course and prognosis of that disorder.
The bidirectional relationship b...
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"The bidirectional relationship between major depressive disorder and obesity often creates a feedback cycle that challenges both patients and health-care providers."
New Review
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New Review
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Postpartum anxiety: a state-of-the-art review
Although there has been increasing interest in the study of postpartum anxiety in
recent years, it remains an emerging field. We present a state-of-the-art review of
postpartum anxiety, with the aim o...
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"As awareness increases of the prevalence and effect of postpartum anxiety, this is the moment to evaluate the state of the existing evidence, as well as the gaps in that evidence that should guide future research."
New Review
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New Review
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Theta burst stimulation of temporo-parietal cortex regions for the treatment of persistent auditory hallucinations: a multicentre, randomised, sham-controlled, triple-blind phase 3 trial in Germany
Sequential bilateral temporo-parietal cTBS over 3 weeks was safe and effective for
reducing auditory verbal hallucinations in adults with schizophrenia spectrum disorder.
This trial establishes cTBS a...
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"The results of this phase 3 study [...] provide evidence supporting the routine clinical use of cTBS, a brief and more efficient form of rTMS, in treating patients with schizophrenia spectrum disorder & persistent auditory verbal hallucinations."
New Article
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New Article
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"Additional preventive strategies to mitigate the risk of infections in patients using clozapine, especially among older adults, might be necessary if current regular haematological monitoring is reduced."
New research Article
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New research Article
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Immersive virtual reality-assisted therapy targeting persistent auditory verbal hallucinations in patients diagnosed with schizophrenia spectrum disorders in Denmark: the Challenge assessor-masked, ra...
Challenge-VRT showed short-term efficacy in reducing the severity of auditory verbal
hallucinations in patients with schizophrenia, and the findings support further development
and evaluation of immer...
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"the first fully powered trial to assess the efficacy and safety of an immersive virtual avatar-based intervention [...]
Challenge-VRT was significantly more effective than enhanced treatment-as-usual in reducing the severity of auditory hallucinations"
New Article
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Challenge-VRT was significantly more effective than enhanced treatment-as-usual in reducing the severity of auditory hallucinations"
New Article
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Absolute neutrophil count and adverse drug reaction monitoring during clozapine treatment: consensus guidelines from a global Delphi panel
Despite its superior effectiveness for treatment-resistant schizophrenia, clozapine
has a high burden of adverse drug reactions (ADRs), which require monitoring and treatment.
This global Delphi study...
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"This global Delphi study has established consensus guidelines for absolute neutrophil count (ANC) thresholds for consideration of clozapine cessation and provided monitoring protocols for ADR management."
New Position Paper
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New Position Paper
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Autism in schizophrenia and its original link to self-disorder: returning a borrowed concept
Autism was introduced by Eugen Bleuler in 1910 as a defining feature of schizophrenia,
and it remained so for 80 years. However, the concept was borrowed by Leo Kanner and
Hans Asperger to describe an...
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"patients with schizophrenia, who exhibit autistic features, risk being misdiagnosed with autism spectrum disorder and receiving inadequate treatment. [...] it is important to rediscover what autism in schizophrenia is"
New Personal View
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New Personal View
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Values and preferences regarding the health sector response to interpersonal violence against transgender and gender-diverse individuals: a systematic review
Transgender and gender-diverse (TGD) people are disproportionately affected by interpersonal
violence and face barriers to accessing post-violence health services globally. Post-violence
care guidelin...
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"Although research has documented negative health-care experiences among TGD [trans & gender diverse] populations, less is known about what individuals value or prefer when seeking post-violence health services."
New Review online now: www.thelancet.com/journals/lan...
New Review online now: www.thelancet.com/journals/lan...
Our June issue is out!
Cover image by Alina Kurokhtina
Explore the issue here www.thelancet.com/journals/lan...
Cover image by Alina Kurokhtina
Explore the issue here www.thelancet.com/journals/lan...
Association between genetic liability to physical health conditions and comorbidities in individuals with severe mental illness: an analysis of two cross-sectional observational studies in the UK
Our findings support the role of genetic risk in physical health comorbidities among
individuals with severe mental illness. Genetic liability to physical health conditions
was more strongly associate...
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"The strong association between genetic liability to physical health conditions and comorbidities suggests that genetic risk contributes in addition to environmental and clinical factors in driving multimorbidity in this population"
New free research Article
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New free research Article
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A digital therapeutic for people with borderline personality disorder in Germany (EPADIP-BPD): a pragmatic, assessor-blind, parallel-group, randomised controlled trial
This trial provides tentative evidence of the effectiveness and absence of safety
concerns of the digital therapeutic, priovi, in the treatment of individuals with
BPD.
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"This trial provides tentative evidence of the effectiveness and absence of safety concerns for this digital therapeutic in the treatment of people with BPD, even if they are not currently treated by a psychiatrist or psychotherapist."
Free research Article:
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Free research Article:
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Setting the research agenda for mental health
At a time when publicly funded research is under intense scrutiny, it is apposite
to ask who should influence where and how the money is spent. At The Lancet Psychiatry,
we believe patients and their ...
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“At a time when publicly funded research is under intense scrutiny, it is apposite to ask who should influence where and how the money is spent.”
Our May Editorial:
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Our May Editorial:
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Efficacy and safety of brexpiprazole in adolescents with schizophrenia: a multicountry, randomised, double-blind, placebo-controlled, phase 3 trial with an active reference
In adolescents with schizophrenia, brexpiprazole 2–4 mg/day was associated with greater
reduction in symptom severity than placebo over 6 weeks. The safety profile of brexpiprazole
in adolescents was ...
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"In adolescents with schizophrenia, brexpiprazole 2–4 mg/day was associated with greater reduction in symptom severity than placebo over 6 weeks. The safety profile of brexpiprazole in adolescents was consistent with trials in adult patients."
New free Article:
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New free Article:
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Comparative cardiovascular safety of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis
Practitioners should monitor blood pressure and pulse in patients with ADHD treated
with any pharmacological intervention, and not stimulants only. Given the short duration
of available randomised con...
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"Taken together, our data support that ADHD medications have direct effects on cardiovascular safety, and that all examined ADHD medications could lead to changes in haemodynamic values in the short term."
New research Article: www.thelancet.com/journals/lan...
New research Article: www.thelancet.com/journals/lan...
Reposted by The Lancet Psychiatry
The Mental Elf
@thementalelf.bsky.social
· Mar 19
Quetiapine may pip lithium to the augmentation post in 'treatment resistant depression': results from the LQD study buff.ly/Y7jCajZ
#LQDstudy #Quetiapine #Lithium #Depression #RCT
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#LQDstudy #Quetiapine #Lithium #Depression #RCT
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