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theHarrisLab
@theharrislab.bsky.social
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The Harris Lab @ASU.
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A threshold level of JNK activates damage-responsive enhancers via JAK/STAT to promote tissue regeneration

Read this #LifelongDevSI #OA Research Article by John W. Quinn, Robin E. Harris and colleagues in our Stem Cells and Regeneration section doi.org/10.1242/dev....
(D-D′) The peripheral DRWNT activity (yellow arrowhead) is lost upon Stat92E knockdown, while JNK activity is unaffected. (E) Posterior-specific Stat92E knockdown (hh-GAL4) shows reduced DRWNT in posterior wound periphery (yellow arrowheads) compared to wild-type anterior; anterior/posterior boundary indicated by dashed line. (F) DRWNTΔSTAT-GFP (lacking Stat92E sites) shows loss of peripheral activity at 18 h AHS (yellow arrowhead)
October 31, 2025 at 5:53 PM