Therapeutic Advances in Gastroenterology
@tagastroenterol.bsky.social
A gold open access peer-reviewed journal publishing high-quality articles across all areas of #gastroenterology, #hepatology and related disciplines.
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The EARLY study will track patients with incidental, asymptomatic IBD to uncover genetic, immune & clinical markers of disease in its preclinical phase. With 10-year follow-up, it aims to predict outcomes & guide early intervention strategies.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 3:05 PM
The EARLY study will track patients with incidental, asymptomatic IBD to uncover genetic, immune & clinical markers of disease in its preclinical phase. With 10-year follow-up, it aims to predict outcomes & guide early intervention strategies.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Survey of Moroccan gastroenterologists shows heavy workloads (50h+/week) linked to high rates of musculoskeletal (87%), digestive (71%), anxiety (24%), depression (46%), and burnout (72%). Younger doctors most affected, with worse work–life balance.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 3:03 PM
Survey of Moroccan gastroenterologists shows heavy workloads (50h+/week) linked to high rates of musculoskeletal (87%), digestive (71%), anxiety (24%), depression (46%), and burnout (72%). Younger doctors most affected, with worse work–life balance.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
US cohort shows vitamin D deficiency increases risk of cirrhosis HR 1.30, HCC HR 1.22, and mortality HR 1.14. Achieving sufficiency lowered death risk HR 0.93 but not cirrhosis. Lowest liver risk seen at 40–60 ng/mL, suggesting a U-shaped pattern.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 3:01 PM
US cohort shows vitamin D deficiency increases risk of cirrhosis HR 1.30, HCC HR 1.22, and mortality HR 1.14. Achieving sufficiency lowered death risk HR 0.93 but not cirrhosis. Lowest liver risk seen at 40–60 ng/mL, suggesting a U-shaped pattern.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Review outlines strategies for 10–20 mm non-pedunculated colorectal polyps: CSP offers low AE risk, modified EMR boosts en bloc rates by 15–20%, while ESD is preferred for invasive/fibrotic cases. Emerging bipolar/low-power snares may cut thermal AEs.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
October 3, 2025 at 2:59 PM
Review outlines strategies for 10–20 mm non-pedunculated colorectal polyps: CSP offers low AE risk, modified EMR boosts en bloc rates by 15–20%, while ESD is preferred for invasive/fibrotic cases. Emerging bipolar/low-power snares may cut thermal AEs.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Study (n=50) in unresectable #HCC: response to TACE was tied to peripheral T-cell profiles. Non-responders had more senescent/exhausted CD8+ T cells & fewer memory stem cells. Baseline CD8+ TSCM & TSenescence subsets may predict TACE efficacy & survival.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 26, 2025 at 3:05 PM
Study (n=50) in unresectable #HCC: response to TACE was tied to peripheral T-cell profiles. Non-responders had more senescent/exhausted CD8+ T cells & fewer memory stem cells. Baseline CD8+ TSCM & TSenescence subsets may predict TACE efficacy & survival.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Cross-sectional study (n=345) in China: 39.7% of ulcerative colitis pts reported disability (IBD-DI). Disability linked to higher disease activity, fatigue, depression & lower BMI. Independent risk factors: BMI, Mayo score, fatigue, depression.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 26, 2025 at 3:00 PM
Cross-sectional study (n=345) in China: 39.7% of ulcerative colitis pts reported disability (IBD-DI). Disability linked to higher disease activity, fatigue, depression & lower BMI. Independent risk factors: BMI, Mayo score, fatigue, depression.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Retrospective study (n=65) of HER2+ advanced #GastricCancer treated with trastuzumab deruxtecan: ORR 36%, median OS 7.7 mo. Early tumor shrinkage was a strong predictor of longer PFS (HR 0.21) & OS (HR 0.23). T-DXd showed efficacy with manageable safety.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 26, 2025 at 2:58 PM
Retrospective study (n=65) of HER2+ advanced #GastricCancer treated with trastuzumab deruxtecan: ORR 36%, median OS 7.7 mo. Early tumor shrinkage was a strong predictor of longer PFS (HR 0.21) & OS (HR 0.23). T-DXd showed efficacy with manageable safety.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Retrospective cohort in Vietnam: delayed ERCP for stone-induced acute cholangitis gave comparable outcomes to early ERCP, with similar mortality/readmission. Early ERCP shortened hospital stay, but dERCP offers a safe option in resource-limited settings
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 26, 2025 at 2:55 PM
Retrospective cohort in Vietnam: delayed ERCP for stone-induced acute cholangitis gave comparable outcomes to early ERCP, with similar mortality/readmission. Early ERCP shortened hospital stay, but dERCP offers a safe option in resource-limited settings
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Prospective study in #IBD: 91.8% accepted switch from originator adalimumab to biosimilars. Persistence 60.4% at 12 mo; remission maintained in 90.4%. Injection site pain was main discontinuation cause. Majority reported positive experience with switch
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 26, 2025 at 2:52 PM
Prospective study in #IBD: 91.8% accepted switch from originator adalimumab to biosimilars. Persistence 60.4% at 12 mo; remission maintained in 90.4%. Injection site pain was main discontinuation cause. Majority reported positive experience with switch
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Retrospective analysis of 1259 colorectal polyps (1025 pts) after EMR shows complete titanium clip closure reduces delayed postpolypectomy bleeding (#DPPB). Partial closure, male sex & larger polyps were significant risk factors. Complete closure is key
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 18, 2025 at 12:59 PM
Retrospective analysis of 1259 colorectal polyps (1025 pts) after EMR shows complete titanium clip closure reduces delayed postpolypectomy bleeding (#DPPB). Partial closure, male sex & larger polyps were significant risk factors. Complete closure is key
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Multicentre Korean cohort (n=127) assessed switching #IBD pts from IV to SC infliximab. 1-yr treatment persistence was high (92.1%) with no difference between remission & non-remission groups. SC IFX showed stable or improved outcomes & manageable safety
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
September 18, 2025 at 12:57 PM
Multicentre Korean cohort (n=127) assessed switching #IBD pts from IV to SC infliximab. 1-yr treatment persistence was high (92.1%) with no difference between remission & non-remission groups. SC IFX showed stable or improved outcomes & manageable safety
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
Review on #GIcancer immunotherapy highlights integrated biomarker strategies—from molecular (MSI, TMB, PD-L1), histopathology (CD8+/Treg ratio), to imaging. Combining genetic & imaging data may improve patient selection & treatment monitoring
Read here: journals.sagepub.com/doi/epdf/10....
Read here: journals.sagepub.com/doi/epdf/10....
September 18, 2025 at 12:55 PM
Review on #GIcancer immunotherapy highlights integrated biomarker strategies—from molecular (MSI, TMB, PD-L1), histopathology (CD8+/Treg ratio), to imaging. Combining genetic & imaging data may improve patient selection & treatment monitoring
Read here: journals.sagepub.com/doi/epdf/10....
Read here: journals.sagepub.com/doi/epdf/10....
In a 240-patient cohort, fecal microbiota transplant for recurrent C. difficile infection failed in 24.6% of cases (18.3% recurrence, 7.1% death within 1 year). Older age, multiple prior episodes, and diabetes were significantly associated with failure.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
May 16, 2025 at 6:00 PM
In a 240-patient cohort, fecal microbiota transplant for recurrent C. difficile infection failed in 24.6% of cases (18.3% recurrence, 7.1% death within 1 year). Older age, multiple prior episodes, and diabetes were significantly associated with failure.
journals.sagepub.com/doi/epdf/10....
journals.sagepub.com/doi/epdf/10....
In the phase IIIb CDI-SCOPE trial, fecal microbiota, live-jslm (REBYOTA®) delivered via colonoscopy prevented CDI recurrence in 95.1% of patients over 8 weeks.
Only 9.8% experienced mild, RBL-related TEAEs.
Safe, practical, and effective.
🔗 journals.sagepub.com/doi/epdf/10....
Only 9.8% experienced mild, RBL-related TEAEs.
Safe, practical, and effective.
🔗 journals.sagepub.com/doi/epdf/10....
May 16, 2025 at 5:58 PM
In the phase IIIb CDI-SCOPE trial, fecal microbiota, live-jslm (REBYOTA®) delivered via colonoscopy prevented CDI recurrence in 95.1% of patients over 8 weeks.
Only 9.8% experienced mild, RBL-related TEAEs.
Safe, practical, and effective.
🔗 journals.sagepub.com/doi/epdf/10....
Only 9.8% experienced mild, RBL-related TEAEs.
Safe, practical, and effective.
🔗 journals.sagepub.com/doi/epdf/10....
🩸 A 29-expert Delphi panel reached consensus on 36 statements for managing delayed post-polypectomy bleeding.
Key recommendations: risk stratification to reduce unnecessary colonoscopies, and guidance for antithrombotic and hemostatic management
🔗 journals.sagepub.com/doi/epdf/10....
Key recommendations: risk stratification to reduce unnecessary colonoscopies, and guidance for antithrombotic and hemostatic management
🔗 journals.sagepub.com/doi/epdf/10....
May 16, 2025 at 5:55 PM
🩸 A 29-expert Delphi panel reached consensus on 36 statements for managing delayed post-polypectomy bleeding.
Key recommendations: risk stratification to reduce unnecessary colonoscopies, and guidance for antithrombotic and hemostatic management
🔗 journals.sagepub.com/doi/epdf/10....
Key recommendations: risk stratification to reduce unnecessary colonoscopies, and guidance for antithrombotic and hemostatic management
🔗 journals.sagepub.com/doi/epdf/10....
🧠 In 1344 non-sedated EGD patients, a pre-procedural anxiety score >36 predicted higher odds of incomplete or poor-quality exams (AUC=0.720).
Each 1-point increase in STAI-I raised failure odds by 3.8%.
Routine anxiety screening could improve outcomes
🔗 journals.sagepub.com/doi/epdf/10....
Each 1-point increase in STAI-I raised failure odds by 3.8%.
Routine anxiety screening could improve outcomes
🔗 journals.sagepub.com/doi/epdf/10....
May 16, 2025 at 5:54 PM
🧠 In 1344 non-sedated EGD patients, a pre-procedural anxiety score >36 predicted higher odds of incomplete or poor-quality exams (AUC=0.720).
Each 1-point increase in STAI-I raised failure odds by 3.8%.
Routine anxiety screening could improve outcomes
🔗 journals.sagepub.com/doi/epdf/10....
Each 1-point increase in STAI-I raised failure odds by 3.8%.
Routine anxiety screening could improve outcomes
🔗 journals.sagepub.com/doi/epdf/10....
In unresectable perihilar cholangiocarcinoma, endoscopic therapy goes beyond biliary drainage.
ERCP-based approaches + adjuncts like RFA, PDT & EUS methods offer therapeutic promise where surgery isn’t an option.
doi.org/10.1177/1756...
ERCP-based approaches + adjuncts like RFA, PDT & EUS methods offer therapeutic promise where surgery isn’t an option.
doi.org/10.1177/1756...
May 9, 2025 at 12:20 PM
In unresectable perihilar cholangiocarcinoma, endoscopic therapy goes beyond biliary drainage.
ERCP-based approaches + adjuncts like RFA, PDT & EUS methods offer therapeutic promise where surgery isn’t an option.
doi.org/10.1177/1756...
ERCP-based approaches + adjuncts like RFA, PDT & EUS methods offer therapeutic promise where surgery isn’t an option.
doi.org/10.1177/1756...
Smoking, MASLD, cerebrovascular disease, H. pylori persistence, multiple lesions & severe atrophic gastritis all linked to metachronous gastric cancer post-curative ESD.
A nomogram showed strong predictive accuracy (C-index up to 0.845).
doi.org/10.1177/1756...
A nomogram showed strong predictive accuracy (C-index up to 0.845).
doi.org/10.1177/1756...
May 9, 2025 at 12:17 PM
Smoking, MASLD, cerebrovascular disease, H. pylori persistence, multiple lesions & severe atrophic gastritis all linked to metachronous gastric cancer post-curative ESD.
A nomogram showed strong predictive accuracy (C-index up to 0.845).
doi.org/10.1177/1756...
A nomogram showed strong predictive accuracy (C-index up to 0.845).
doi.org/10.1177/1756...
Anti-reflux mucosectomy significantly improved LES pressure, Hill’s grade, and GERD-related symptom scores vs argon plasma coagulation in Barrett’s esophagus.
A stronger reflux barrier with lower lesion residue—supporting ARMS as a dual-target strategy.
doi.org/10.1177/1756...
A stronger reflux barrier with lower lesion residue—supporting ARMS as a dual-target strategy.
doi.org/10.1177/1756...
May 9, 2025 at 11:40 AM
Anti-reflux mucosectomy significantly improved LES pressure, Hill’s grade, and GERD-related symptom scores vs argon plasma coagulation in Barrett’s esophagus.
A stronger reflux barrier with lower lesion residue—supporting ARMS as a dual-target strategy.
doi.org/10.1177/1756...
A stronger reflux barrier with lower lesion residue—supporting ARMS as a dual-target strategy.
doi.org/10.1177/1756...
In MASLD and MetALD, current smoking significantly worsened survival and increased risks of cirrhosis, CVD, and liver-related mortality. Never smokers had lowest risks across most outcomes.
📊 Supports strong cessation strategies in liver disease care.
doi.org/10.1177/1756...
📊 Supports strong cessation strategies in liver disease care.
doi.org/10.1177/1756...
May 9, 2025 at 11:36 AM
In MASLD and MetALD, current smoking significantly worsened survival and increased risks of cirrhosis, CVD, and liver-related mortality. Never smokers had lowest risks across most outcomes.
📊 Supports strong cessation strategies in liver disease care.
doi.org/10.1177/1756...
📊 Supports strong cessation strategies in liver disease care.
doi.org/10.1177/1756...
Reposted by Therapeutic Advances in Gastroenterology
Impact of early tumor shrinkage on survival outcomes in patients with HER2-positive advanced gastric cancer treated with trastuzumab deruxtecan in third- or later-line settings - Apr 24, 2025
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journals.sagepub.com/doi/10.1177/...
#oncsky #openaccess
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#oncsky #openaccess
May 2, 2025 at 6:05 PM
Impact of early tumor shrinkage on survival outcomes in patients with HER2-positive advanced gastric cancer treated with trastuzumab deruxtecan in third- or later-line settings - Apr 24, 2025
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#oncsky #openaccess
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#oncsky #openaccess
Reposted by Therapeutic Advances in Gastroenterology
Factors associated with failure of fecal microbiota transplant for recurrent Clostridioides difficile infection - Apr 23, 2025
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#gastroenterology #medicine #medsky #openaccess
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#gastroenterology #medicine #medsky #openaccess
May 2, 2025 at 5:57 PM
Factors associated with failure of fecal microbiota transplant for recurrent Clostridioides difficile infection - Apr 23, 2025
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#gastroenterology #medicine #medsky #openaccess
@journals.sagepub.com @tagastroenterol.bsky.social
journals.sagepub.com/doi/10.1177/...
#gastroenterology #medicine #medsky #openaccess
🧠 LLMs show promise for GI research—supporting clinical decisions, data extraction & patient comms—but risks like hallucinations & bias remain.
This framework outlines practical steps: goal-setting, fine-tuning, EHR integration & real-world validation
🔗 journals.sagepub.com/doi/epdf/10....
This framework outlines practical steps: goal-setting, fine-tuning, EHR integration & real-world validation
🔗 journals.sagepub.com/doi/epdf/10....
April 16, 2025 at 4:30 PM
🧠 LLMs show promise for GI research—supporting clinical decisions, data extraction & patient comms—but risks like hallucinations & bias remain.
This framework outlines practical steps: goal-setting, fine-tuning, EHR integration & real-world validation
🔗 journals.sagepub.com/doi/epdf/10....
This framework outlines practical steps: goal-setting, fine-tuning, EHR integration & real-world validation
🔗 journals.sagepub.com/doi/epdf/10....
🧠 In 104 patients with walled-off necrosis, tailoring LAMS dwell time by imaging & symptoms led to similar success & safety—despite longer stent time (>4wks) in necrosis-heavy cases. Early removal = fewer necrosectomies.
Read more: journals.sagepub.com/doi/epdf/10....
Read more: journals.sagepub.com/doi/epdf/10....
April 16, 2025 at 4:23 PM
🧠 In 104 patients with walled-off necrosis, tailoring LAMS dwell time by imaging & symptoms led to similar success & safety—despite longer stent time (>4wks) in necrosis-heavy cases. Early removal = fewer necrosectomies.
Read more: journals.sagepub.com/doi/epdf/10....
Read more: journals.sagepub.com/doi/epdf/10....
🚨 For massive rectal GISTs >5cm, transanal endoscopic resection (taLR) matched radical surgery on 5-yr DFS (94.1% vs 100%, p=0.405), while reducing OR time, hospital stay & preserving anal function. A QoL-preserving alternative.
Read here: journals.sagepub.com/doi/epdf/10....
Read here: journals.sagepub.com/doi/epdf/10....
April 11, 2025 at 4:45 PM
🚨 For massive rectal GISTs >5cm, transanal endoscopic resection (taLR) matched radical surgery on 5-yr DFS (94.1% vs 100%, p=0.405), while reducing OR time, hospital stay & preserving anal function. A QoL-preserving alternative.
Read here: journals.sagepub.com/doi/epdf/10....
Read here: journals.sagepub.com/doi/epdf/10....