Dr. Cornelius Taabazuing
@taabaman.bsky.social
I'm an assistant professor in the Biochemistry Department at UPenn. The focus of my lab is on understanding mechanisms of cell death that regulate the innate immune system.
Check out our latest work led by two talented postdocs, Madhura @mkulkarni.bsky.social and Chris. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.
Inflammasomes are multiprotein signaling platforms that activate inflammatory caspases to induce pyroptosis. In humans, canonical inflammasomes activate CASP1, which cleaves the pore-forming protein g...
www.biorxiv.org
November 3, 2025 at 10:09 PM
Check out our latest work led by two talented postdocs, Madhura @mkulkarni.bsky.social and Chris. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dr. Cornelius Taabazuing
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
May 1, 2025 at 6:17 PM
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
Reposted by Dr. Cornelius Taabazuing
Two new preprints online today!
One with @dremilygoldberg.bsky.social on lysine lactylation
www.biorxiv.org/content/10.1...
Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...
One with @dremilygoldberg.bsky.social on lysine lactylation
www.biorxiv.org/content/10.1...
Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...
Class I histone deacetylases catalyze lysine lactylation
Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...
www.biorxiv.org
February 28, 2025 at 8:45 PM
Two new preprints online today!
One with @dremilygoldberg.bsky.social on lysine lactylation
www.biorxiv.org/content/10.1...
Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...
One with @dremilygoldberg.bsky.social on lysine lactylation
www.biorxiv.org/content/10.1...
Another with @taabaman.bsky.social on new peptide tools to study caspases www.biorxiv.org/content/10.1...
If you're preparing for graduate school interviews, here's a resource to help you prepare.
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
A practical guide to graduate school interviewing for historically excluded individuals | American Journal of Physiology-Heart and Circulatory Physiology
journals.physiology.org
January 16, 2025 at 9:30 PM
If you're preparing for graduate school interviews, here's a resource to help you prepare.
journals.physiology.org/doi/full/10....
journals.physiology.org/doi/full/10....
Manuscript submitted! Kudos to the smart, hardworking trainees that made this gift possible for the holidays! I truly appreciate you all. 🎉🥂🥳
December 22, 2024 at 4:38 AM
Manuscript submitted! Kudos to the smart, hardworking trainees that made this gift possible for the holidays! I truly appreciate you all. 🎉🥂🥳
Reposted by Dr. Cornelius Taabazuing
It was great to finally met Dr. @taabaman.bsky.social in person. Your science and commitment to education will continue making an impact. #CellBio2024
December 19, 2024 at 2:29 PM
It was great to finally met Dr. @taabaman.bsky.social in person. Your science and commitment to education will continue making an impact. #CellBio2024
Please help us welcome the newest postdoc to join the Taabazuing lab. We are all immigrants in the lab, but Ashutosh is our first international student hailing from India.
December 14, 2024 at 9:16 PM
Please help us welcome the newest postdoc to join the Taabazuing lab. We are all immigrants in the lab, but Ashutosh is our first international student hailing from India.
Feeling recharged after our department retreat in the Poconos last weekend. Huge congrats to our postdoc Madhura for winning the poster prize! We also welcomed the latest postdoc to join the lab, Ashutosh.
December 13, 2024 at 12:15 PM
Feeling recharged after our department retreat in the Poconos last weekend. Huge congrats to our postdoc Madhura for winning the poster prize! We also welcomed the latest postdoc to join the lab, Ashutosh.
Reposted by Dr. Cornelius Taabazuing
Check out our lab's latest paper describing a mutually inhibitory complex between DPP9 and KEAP1
www.jbc.org/article/S002...
www.jbc.org/article/S002...
The Serine Protease DPP9 and the Redox Sensor KEAP1 Form a Mutually Inhibitory Complex
Synthetic inhibitors of the serine protease DPP9 activate the related NLRP1 and CARD8
inflammasomes and stimulate powerful innate immune responses. Thus, it seems plausible
that a biomolecule similarl...
www.jbc.org
November 29, 2024 at 5:14 PM
Check out our lab's latest paper describing a mutually inhibitory complex between DPP9 and KEAP1
www.jbc.org/article/S002...
www.jbc.org/article/S002...
I'm SO thankful for my amazing lab! Out of over 350 global entries, my lab manager is in the finals for lab manager of the year award 2024. Help me show my appreciation by voting for Bohdana Discher for this year's award. Vote daily until December 1st. Thanks!
www.ptglab.com/news/company...
www.ptglab.com/news/company...
Best Lab Manager Award
Proteintech is offering a $1000 award for the most outstanding lab manager.
www.ptglab.com
November 29, 2024 at 4:10 AM
I'm SO thankful for my amazing lab! Out of over 350 global entries, my lab manager is in the finals for lab manager of the year award 2024. Help me show my appreciation by voting for Bohdana Discher for this year's award. Vote daily until December 1st. Thanks!
www.ptglab.com/news/company...
www.ptglab.com/news/company...
All letters of recommendations have been submitted so the only thing left to do now is write our next paper. Hoping to give the lab a submission gift for Christmas.
November 27, 2024 at 3:03 AM
All letters of recommendations have been submitted so the only thing left to do now is write our next paper. Hoping to give the lab a submission gift for Christmas.
Reposted by Dr. Cornelius Taabazuing
OK, #immunology Bluesky LFG!
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
November 18, 2024 at 7:06 PM
OK, #immunology Bluesky LFG!
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
Hi all! My name is Cornelius, and I'm an assistant professor in the Department of Biochemistry and Biophysics @pennmedicine.bsky.social @upenn.bsky.social. My lab is interested in host-pathogen interactions with a focus on how the host responds to infections. I'm passionate about mentoring, too!
November 18, 2024 at 4:09 AM
Hi all! My name is Cornelius, and I'm an assistant professor in the Department of Biochemistry and Biophysics @pennmedicine.bsky.social @upenn.bsky.social. My lab is interested in host-pathogen interactions with a focus on how the host responds to infections. I'm passionate about mentoring, too!
Reposted by Dr. Cornelius Taabazuing
go.bsky.app/2bqX3T7 - please send me your @bsky.app handles to include in this growing community.
November 17, 2024 at 10:05 PM
go.bsky.app/2bqX3T7 - please send me your @bsky.app handles to include in this growing community.