Sakari Vanharanta
@svanharanta.bsky.social
Sigrid Jusélius Professor, Translational Cancer Medicine Program & Department of Biochemistry and Developmental Biology, University of Helsinki, Finland. #cancer #genomics #transcription #chromatin
New issue of Annual Reviews of Cancer Biology is out!
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Annual Review of Cancer Biology | Annual Reviews
AIMS AND SCOPE OF JOURNAL: The Annual Review of Cancer Biology reviews a range of subjects in cancer research that represent important and emerging areas in the field. With recent advances in our unde...
www.annualreviews.org
April 14, 2025 at 5:44 PM
New issue of Annual Reviews of Cancer Biology is out!
www.annualreviews.org/content/jour...
www.annualreviews.org/content/jour...
Very interesting work on the role of germline genetics in somatic tumor evolution.
🌟NEW PREPRINT ALERT!🌟
We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
www.biorxiv.org/content/10.1...
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We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
www.biorxiv.org/content/10.1...
🧵[1/12]
Genetic background sets the trajectory of cancer evolution
Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...
www.biorxiv.org
January 16, 2025 at 10:33 AM
Very interesting work on the role of germline genetics in somatic tumor evolution.
Last few days to apply👇! In addition to hot science, our campus offers refreshing dips within walking distance 💪🏖️ #BalticSea #Helsinki
January 7, 2025 at 12:53 PM
Last few days to apply👇! In addition to hot science, our campus offers refreshing dips within walking distance 💪🏖️ #BalticSea #Helsinki
Reposted by Sakari Vanharanta
Looking for a PhD? Follow this🧵 to know how Adaptmet's innovative training will combine continuous training in cutting-edge metastasis research with custom-made network-wide events to enhance, accelerate & elevate the skills, capacities & network of our doctoral candidates (DCs)
December 20, 2024 at 12:06 PM
Looking for a PhD? Follow this🧵 to know how Adaptmet's innovative training will combine continuous training in cutting-edge metastasis research with custom-made network-wide events to enhance, accelerate & elevate the skills, capacities & network of our doctoral candidates (DCs)
Reposted by Sakari Vanharanta
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Engineered extrachromosomal oncogene amplifications promote tumorigenesis - Nature
Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene a...
www.nature.com
December 18, 2024 at 4:54 PM
🧪1/ 🚨New paper on ecDNAs from our lab!
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇
www.nature.com/articles/s41...
Reposted by Sakari Vanharanta
Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
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www.nature.com/articles/s41...
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www.nature.com/articles/s41...
CRISPR-StAR enables high-resolution genetic screening in complex in vivo models - Nature Biotechnology
Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls.
www.nature.com
December 16, 2024 at 12:02 PM
Today we published a new paradigm to do CRISPR screens in complex model systems such as in vivo but also e.g. in organoids. The publication came out in Nature Biotechnology.
1/
www.nature.com/articles/s41...
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www.nature.com/articles/s41...
Come join us!
📢 Calling all future cancer researchers! Adaptmet is offering 16 MSCA PhD positions in cutting-edge metastasis research. Follow this thread & get to know the exciting projects on offer among Europe’s best teams from top host institutions! More details 👉https://adaptmet.eu/recruitment/
December 10, 2024 at 3:12 PM
Come join us!
Very interesting insight into tumor-immune interaction under chemotherapy in ovarian cancer. Congrats Anniina, Anna and the teams!
1/n New paper alert 🚨 We're thrilled to share our just published paper in #CancerCell
Do you ever wonder how the #TME in #HGSC changes during chemotherapy? Check it here: www.sciencedirect.com/science/arti... and let’s dive into the highlights together #spatialbiology #ovariancancer #cancerresarch
Do you ever wonder how the #TME in #HGSC changes during chemotherapy? Check it here: www.sciencedirect.com/science/arti... and let’s dive into the highlights together #spatialbiology #ovariancancer #cancerresarch
Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer
Anti-tumor immunity is crucial for high-grade serous ovarian cancer (HGSC) prognosis, yet its adaptation upon standard chemotherapy remains poorly und…
www.sciencedirect.com
December 10, 2024 at 1:30 PM
Very interesting insight into tumor-immune interaction under chemotherapy in ovarian cancer. Congrats Anniina, Anna and the teams!
Reposted by Sakari Vanharanta
New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature
Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.
www.nature.com
December 4, 2024 at 6:23 PM
New in @natureportfolio.bsky.social from the Tuomas Tammela Lab: how aging suppresses tumorigenesis and stemness in the lung by promoting functional iron insufficiency in the alveolar epithelium. Interestingly, this renders aged cells resistant to ferroptosis. #OncSky www.nature.com/articles/s41...
Reposted by Sakari Vanharanta
Come join us and @svanharanta.bsky.social @cedric-blanpain.bsky.social Roger Gomis @irbbarcelona.bsky.social @obenaufa.bsky.social Karin de Visser @nkinl.bsky.social @grauperalab.bsky.social @prat-aleix-md.bsky.social @vickysanzmoreno.bsky.social @johannajoyce.bsky.social @momobentires.bsky.social
December 4, 2024 at 2:03 PM
Inflammatory monocytes can restimulate T cells in tumors, and cancer cell-induced disruption of this process can lead to tumor immune evasion. Details 👇 in the wonderful 🧵 by @obenaufa.bsky.social and the paper published today @Nature. What a privilege it has been to be part of this amazing team!
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 8:24 PM
Inflammatory monocytes can restimulate T cells in tumors, and cancer cell-induced disruption of this process can lead to tumor immune evasion. Details 👇 in the wonderful 🧵 by @obenaufa.bsky.social and the paper published today @Nature. What a privilege it has been to be part of this amazing team!
Hello Bluesky, we are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details here: adaptmet.eu/recruitment/
Recruitment
Recruitment is now open!
Apply for one of the 16 positions availablein the Adaptmet network and build your futureas a researcher in metastasis!
Adaptmet is offering generous three-year fellowship...
adaptmet.eu
November 25, 2024 at 12:07 PM
Hello Bluesky, we are recruiting PhD students in cancer and metastasis biology! This is a fantastic program that brings together several leading European research institutes. Details here: adaptmet.eu/recruitment/