Gold nanoparticles (AuNPs) exhibit localized surface plasmon resonance (LSPR) and are promising photothermal agents. However, the aggregation susceptibility and poor colloidal stability limit their bi...

Increasing temperatures threaten cold-adapted pollinators such as Arctic bumblebees by disrupting their physiology. This study found that thorax acceleration during non-flight vibrations peaks at 25 °...

新自由主義の台頭で日本社会に格差が定着した。非正規労働者層が誕生し、人口の三割が経済的理由から家庭を持つことができないという、膨大な貧困層を形成した。人々は格差の存在をはっきりと感じ、豊かな人々は豊かさを、貧しい人々は貧しさをそれぞれに自覚しながら日々を送る。豊かさの程度によって日本はすでに分断され、「新しい階級社会」が成立しているのだ。最新の調査データが物語る、現代日本の恐るべき現実！！ 　かつ...

The viscosity of the plasma membrane in living cells is a crucial biophysical parameter that regulates cellular functions. We categorize the plasma membrane viscosity into short-range and long-range v...

Optical microheating technologies have revealed how biological systems sense heating and cooling at the microscopic scale. Sensing is based on thermosensitive biochemical reactions that frequently eng...

A major challenge in the field of mechanobiology relates to the lack of methods that enable the identification of mechanically active receptors, associated proteins, and the individual cells that disp...

■恐怖と憧憬が共存するあっち側の世界　植物を上手に育てる人を緑の指の持ち主と言うけれど、はたしてこの人は何色の指を持っていたのだろう。安房直子の作品に触れるたび、そんな疑問が胸にわく。彼女が遺（のこ…

ミャクミャクの顔の形をかたどった実物の培養肉が、大阪・関西万博の大阪ヘルスケアパビリオンにお目見えした。顔の赤色の部分が赤身、口が脂肪だ。大阪大学大学院工学研究科や島津製作所などからなる研究グループ…

Thermogenetics uses temperature-sensitive proteins to regulate cellular functions via temperature changes. Compared to optogenetics, which utilizes visible light and is limited by light penetration, t...

Thermoregulation is essential for maintaining homeostasis in mammals under various environmental conditions. Impairment of this function can result in …

インドネシア政府は、新しい入国手続き「All Indonesia」の運用を9月1日に開始した。

最高裁判事を６年余り務めた宇賀克也・東京大名誉教授（７０）が７月、判事を退官した。個性が見えづらいと言われる裁判官にあって、裁判官個人の意見を判決や決定で示す「個別意見」で自身の考えを積極的に打ち出…

Detecting protein biomarkers is critical in fundamental research and clinical investigations of extracellular vesicles (EVs). Despite the prevalent use of antibodies as recognition elements, their app...

Human telomeres exhibit progressive shortening with each replication cycle. This phenomenon plays a critical role in the onset of senescence and the development of cancers. The measurement of absolute telomere length (TL) is not only serving as a marker of aging, but also holds substantial medical relevance. However, current TL measurement technologies face significant challenges, including limited precision, inability to resolve TL heterogeneity or distinguish telomeric signals from interstitial telomeric sequences (ITS), and data inconsistency. Single-molecule mechanical techniques have shown promise in manipulating DNA and providing precise contour length measurements of DNA, making them suitable for assessing TL quantitatively. In this study, we developed a method, named single-molecule terminal restriction fragment (smTRF) analysis, for measuring telomeres at single-molecule resolution. We applied smTRF to seven human cancer cell lines and successfully determined TL ranging from a few to tens of kilobases, highlighting the versatility and high-fidelity performance of the smTRF assay. The smTRF data were validated against results from standard TRF, qPCR, and Q-FISH analysis, demonstrating well agreement and confirming the assay’s reliability in the measurement of average TL. To further test the robustness of smTRF, we measured TL distribution profiles for 48 individuals, establishing the smTRF assay as a reliable tool for the accurate and precise measurement of human TLs. The comprehensive telomere profiles obtained via the smTRF assay promise to provide in-depth insights into public health research, particularly in the study of aging, where TL serves as a critical biomarker.

The conical HIV-1 capsid protects the internal viral genome and facilitates the infection of target cells. Highly potent antivirals, such as the clinically approved drug Lenacapavir (LEN), block HIV-1...