#PostAcute
#Reactivation
The TB paradigm was wrong in 2 ways
We overestimated reactivation (molecular tools showed 30-80% is recent transmission in endemic areas)
We assumed the distinction mattered clinically (it doesn't)
But timing DOES matter epidemiologically. Here's ?
#PostAcute
#Reactivation
The TB paradigm was wrong in 2 ways
We overestimated reactivation (molecular tools showed 30-80% is recent transmission in endemic areas)
We assumed the distinction mattered clinically (it doesn't)
But timing DOES matter epidemiologically. Here's ?
The condition of two nurses, who tested positive for the Nipah virus in Kolkata, remain critical
The confirmed cases of Nipah virus include two nurses, a doctor, & a health staff member.
100 quarantined @organicbotanic.bsky.social
India rushes to contain deadly Nipah virus outbreak after five cases confirmed
West Bengal & Kerala in India have had a history with Nipah Virus Disease as cases have been found in past as well
@organicbotanic.bsky.social @brownecfm.bsky.social
The condition of two nurses, who tested positive for the Nipah virus in Kolkata, remain critical
The confirmed cases of Nipah virus include two nurses, a doctor, & a health staff member.
100 quarantined @organicbotanic.bsky.social
How it is said matters
“Given current 2nd-line drug availability & costs, expected MDR-TB mortality is 40% "
Reality: 2nd-line drug cost $1,000-5,000 for 18 month t/t while generic would cost $100-500
40% mortality is pharmaceutical profit prioritization, not biological inevitability
How it is said matters
“Given current 2nd-line drug availability & costs, expected MDR-TB mortality is 40% "
Reality: 2nd-line drug cost $1,000-5,000 for 18 month t/t while generic would cost $100-500
40% mortality is pharmaceutical profit prioritization, not biological inevitability
History of NVD in West Bengal
Siliguri in 2001 with reports of person-to-person transmission in hospital settings (nosocomial transmission)
Nadia in 2007, reporting five cases & five deaths; 100% mortality @organicbotanic.bsky.social @elhopkins.bsky.social
India rushes to contain deadly Nipah virus outbreak after five cases confirmed
West Bengal & Kerala in India have had a history with Nipah Virus Disease as cases have been found in past as well
@organicbotanic.bsky.social @brownecfm.bsky.social
History of NVD in West Bengal
Siliguri in 2001 with reports of person-to-person transmission in hospital settings (nosocomial transmission)
Nadia in 2007, reporting five cases & five deaths; 100% mortality @organicbotanic.bsky.social @elhopkins.bsky.social
India rushes to contain deadly Nipah virus outbreak after five cases confirmed
West Bengal & Kerala in India have had a history with Nipah Virus Disease as cases have been found in past as well
@organicbotanic.bsky.social @brownecfm.bsky.social
India rushes to contain deadly Nipah virus outbreak after five cases confirmed
West Bengal & Kerala in India have had a history with Nipah Virus Disease as cases have been found in past as well
@organicbotanic.bsky.social @brownecfm.bsky.social
Covid as Protective factor?
Resilience?
I thought resilience was a socio-cultural construct
Precisely why I have reservations with evidence alone science, evidence constructed through statistical power
@organicbotanic.bsky.social @elhopkins.bsky.social
jamanetwork.com/journals/jam...
Covid as Protective factor?
Resilience?
I thought resilience was a socio-cultural construct
Precisely why I have reservations with evidence alone science, evidence constructed through statistical power
@organicbotanic.bsky.social @elhopkins.bsky.social
jamanetwork.com/journals/jam...
Malnutrition-known to be a risk factor for making TB symptomatic.
But our recent experience using a case-control design saw that this & other known risk factors may actually be over exaggerated @organicbotanic.bsky.social @elhopkins.bsky.social @microlabdoc.bsky.social
Malnutrition-known to be a risk factor for making TB symptomatic.
But our recent experience using a case-control design saw that this & other known risk factors may actually be over exaggerated @organicbotanic.bsky.social @elhopkins.bsky.social @microlabdoc.bsky.social
#CleanAirInSchools
The mis-information that it doesn’t impact kids has been busted many times over, yet our effort to correct that is very limited or restricted
@organicbotanic.bsky.social @elhopkins.bsky.social @drinfosec.bsky.social
www.dimsumdaily.hk/hong-kong-re...
#CleanAirInSchools
The mis-information that it doesn’t impact kids has been busted many times over, yet our effort to correct that is very limited or restricted
@organicbotanic.bsky.social @elhopkins.bsky.social @drinfosec.bsky.social
www.dimsumdaily.hk/hong-kong-re...
#NeglectedTropicalDiseases
#DogBite
#OtherAnimalBite
Come & join us as we explore the socio-cultural contextualisation of animal bite & the solutions there to
@organicbotanic.bsky.social @elhopkins.bsky.social
#NeglectedTropicalDiseases
#DogBite
#OtherAnimalBite
Come & join us as we explore the socio-cultural contextualisation of animal bite & the solutions there to
@organicbotanic.bsky.social @elhopkins.bsky.social
Is India witnessing it’s worst floods in the current century
If we go by the situation in North & Northeast India, it may well be
@organicbotanic.bsky.social
While climate science is the earliest to recognise “Outliers/extreme weather conditions” as critical, is it too late to prevent the impact of these?
Have we moved so far ahead that preventing devastation is impossible? @elhopkins.bsky.social @organicbotanic.bsky.social
Is India witnessing it’s worst floods in the current century
If we go by the situation in North & Northeast India, it may well be
@organicbotanic.bsky.social
While climate science is the earliest to recognise “Outliers/extreme weather conditions” as critical, is it too late to prevent the impact of these?
Have we moved so far ahead that preventing devastation is impossible? @elhopkins.bsky.social @organicbotanic.bsky.social
While climate science is the earliest to recognise “Outliers/extreme weather conditions” as critical, is it too late to prevent the impact of these?
Have we moved so far ahead that preventing devastation is impossible? @elhopkins.bsky.social @organicbotanic.bsky.social
Show this to the those who say “vaccines are harmful”
@organicbotanic.bsky.social @elhopkins.bsky.social @drinfosec.bsky.social
www.bbc.com/news/article...
Show this to the those who say “vaccines are harmful”
@organicbotanic.bsky.social @elhopkins.bsky.social @drinfosec.bsky.social
www.bbc.com/news/article...
www.hindustantimes.com/world-news/u...
www.hindustantimes.com/world-news/u...
It was never about “I”
Unfortunately that is being challenged now @organicbotanic.bsky.social @brownecfm.bsky.social @drinfosec.bsky.social @microlabdoc.bsky.social
This man is an existential threat.
It was never about “I”
Unfortunately that is being challenged now @organicbotanic.bsky.social @brownecfm.bsky.social @drinfosec.bsky.social @microlabdoc.bsky.social
India, the country that houses the most humans on this planet is expected to face twice as many heatwave days, 43% rise in extreme rainfall by 2030 @organicbotanic.bsky.social @elhopkins.bsky.social
Extreme weather conditions r no more an outlier- the chances r higher now than before that they will happen every year @organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social
India, the country that houses the most humans on this planet is expected to face twice as many heatwave days, 43% rise in extreme rainfall by 2030 @organicbotanic.bsky.social @elhopkins.bsky.social
Extreme weather conditions r no more an outlier- the chances r higher now than before that they will happen every year @organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social
Extreme weather conditions r no more an outlier- the chances r higher now than before that they will happen every year @organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social
It is not just about rising temperatures or melting glaciers
It is also about patterns/trends/prediction of rains, snow & sunshine
Single-day rainfall for the month of August in nearly a century
@organicbotanic.bsky.social
www.greaterkashmir.com/latest-news/...
It is not just about rising temperatures or melting glaciers
It is also about patterns/trends/prediction of rains, snow & sunshine
Single-day rainfall for the month of August in nearly a century
@organicbotanic.bsky.social
www.greaterkashmir.com/latest-news/...
@organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social
www.nature.com/articles/d41...
@organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social
www.nature.com/articles/d41...
This infection is not just one-off event & we did underestimate it
SARS-CoV-2 infection results in increased macrophage numbers & extensive formation of enlarged lipid-laden macrophages or foam cells
@elhopkins.bsky.social @njbbari3.bsky.social
www.nature.com/articles/s41...
This infection is not just one-off event & we did underestimate it
SARS-CoV-2 infection results in increased macrophage numbers & extensive formation of enlarged lipid-laden macrophages or foam cells
@elhopkins.bsky.social @njbbari3.bsky.social
www.nature.com/articles/s41...
www.cdc.gov/mmwr/volumes...
www.cdc.gov/mmwr/volumes...
In very near future, public health resources will largely be directed towards reducing impact of drug resistance & #XDRTB will partake the largest share of these & yet the rewards will be far from satisfactory
Time to act is now @organicbotanic.bsky.social @elhopkins.bsky.social
Finding Solutions
Instead of asking “who is sick?” our solution asks “is transmission happening here?”—shifting the focus from individuals to locations where airborne spread occurs
@elhopkins.bsky.social @njbbari3.bsky.social @drinfosec.bsky.social
unpolitics.global/pubs/project...
In very near future, public health resources will largely be directed towards reducing impact of drug resistance & #XDRTB will partake the largest share of these & yet the rewards will be far from satisfactory
Time to act is now @organicbotanic.bsky.social @elhopkins.bsky.social
Solutions r a product of Knowledge
& Knowledge is widely distributed- in time, place & person
At a given point in time #Community is the best representative of Knowledge & without it no knowledge ever existed @organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social
Finding Solutions
Instead of asking “who is sick?” our solution asks “is transmission happening here?”—shifting the focus from individuals to locations where airborne spread occurs
@elhopkins.bsky.social @njbbari3.bsky.social @drinfosec.bsky.social
unpolitics.global/pubs/project...
Solutions r a product of Knowledge
& Knowledge is widely distributed- in time, place & person
At a given point in time #Community is the best representative of Knowledge & without it no knowledge ever existed @organicbotanic.bsky.social @elhopkins.bsky.social @njbbari3.bsky.social