Sumedha Nalluru
sumedhanalluru.bsky.social
Sumedha Nalluru
@sumedhanalluru.bsky.social
PhD candidate w/ Helen Barron and Jill O’Reilly at NDCN, University of Oxford. Interested in cognitive maps, memory and psychosis.
Pinned
Our paper "Memory reactivation generates new, adaptive behaviours that reach beyond direct experience" is now out www.nature.com/articles/s41...! With Annie Rawson, Jill O’Reilly and Helen Barron at MRC BNDU @ndcnoxford.bsky.social 1/6
Reposted by Sumedha Nalluru
1/ Excited to share that our symposium review covering cognitive mapping in the PFC just came out in the Journal of Neuroscience: www.jneurosci.org/content/45/4...
Cognitive Maps in the Prefrontal Cortex
The prefrontal cortex (PFC) is critical for our ability to rapidly and flexibly adapt our behavior in new environments based on our previous experience. Despite its importance, the neural substrates a...
www.jneurosci.org
November 15, 2025 at 6:03 PM
Reposted by Sumedha Nalluru
All-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: www.biorxiv.org/content/10.1...
Desensitization of opsin responses during all-optical interrogation depends on imaging parameters
Significance The combination of two-photon calcium imaging and two-photon optogenetic stimulation, termed all-optical interrogation, provides spatial and temporal precision when recording and manipula...
www.biorxiv.org
October 12, 2025 at 12:27 PM
Reposted by Sumedha Nalluru
** We have up to TWO funded PhD positions available in our lab!! Apply below to find new ways to enhance memory👇 Pls retweet **

Deadline: 2nd December

1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6

2. TUS and TMR in humans:
tinyurl.com/jjws5ctj

Happy to chat to interested applicants.
Enhancing memory using cross-species closed-loop Targeted Memory Reactivation | mrcbndu
tinyurl.com
October 6, 2025 at 11:51 AM
Reposted by Sumedha Nalluru
Still a bit stunned but delighted to receive this from @royalsociety.org
October 4, 2025 at 7:25 AM
Reposted by Sumedha Nalluru
I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
October 2, 2025 at 3:46 PM
Reposted by Sumedha Nalluru
I’m super excited to finally put my recent work with @behrenstimb.bsky.social on bioRxiv, where we develop a new mechanistic theory of how PFC structures adaptive behaviour using attractor dynamics in space and time!

www.biorxiv.org/content/10.1...
September 24, 2025 at 12:04 PM
Reposted by Sumedha Nalluru
New unit paper on “Predictive coding model detects novelty on different levels of representation hierarchy”, published in Neural Computation.

www.mrcbndu.ox.ac.uk/papers/predi...

@mrcbndu.ox.ac.uk @ndcnoxford.bsky.social @ox.ac.uk
August 19, 2025 at 9:05 AM
Reposted by Sumedha Nalluru
I'm pleased to share our new work, “Spatio-temporal organization of network activity patterns in the hippocampus”, out in @cp-cellreports.bsky.social !
With Demi Brizee & David Dupret, we track how oscillations and spiking behaviour map onto hippocampal layers using an LFP-based embedding.

(1/13)
June 5, 2025 at 5:10 PM
Reposted by Sumedha Nalluru
Our study using layer fMRI to study the direction of communication between the hippocampus and cortex during perceptual predictions is finally out in Science Advances! Predicted-but-omitted shapes are represented in CA2/3 and correlate specifically with deep layers of PHC, suggesting feedback. 🧠🟦
Communication of perceptual predictions from the hippocampus to the deep layers of the parahippocampal cortex
High-resolution neuroimaging reveals stimulus-specific predictions sent from hippocampus to the neocortex during perception.
www.science.org
May 22, 2025 at 1:55 AM
Reposted by Sumedha Nalluru
Happy to share the latest version of our work on compositional maps in hippocampus with Jo Warren, @jcrwhittington.bsky.social, @behrenstimb.bsky.social. We propose hippocampus constructs maps from cortical building blocks in replay – now with empirical support! www.nature.com/articles/s41... 1/9
Constructing future behavior in the hippocampal formation through composition and replay - Nature Neuroscience
A model of compositional state spaces in the hippocampus shows latent learning and rapid generalization. Bakermans et al. show that this model predicts the emergence of place responses in replay.
www.nature.com
March 17, 2025 at 10:48 AM
Reposted by Sumedha Nalluru
New preprint out with @summerfieldlab.bsky.social! When does new learning interfere with existing knowledge? We compare continual learning in humans and artificial neural networks, revealing similar patterns of transfer & catastrophic interference (1/8) osf.io/preprints/ps...
February 24, 2025 at 11:36 AM
Reposted by Sumedha Nalluru
We are currently building the largest, cross-domain data set of human behavior as part of an open collaborative project. Contributions of any form are welcome, but especially experiments with meta-data from developmental, cross-cultural, or clinical studies.

More details: github.com/marcelbinz/P...
GitHub - marcelbinz/Psych-201
Contribute to marcelbinz/Psych-201 development by creating an account on GitHub.
github.com
January 27, 2025 at 12:43 PM
Our paper "Memory reactivation generates new, adaptive behaviours that reach beyond direct experience" is now out www.nature.com/articles/s41...! With Annie Rawson, Jill O’Reilly and Helen Barron at MRC BNDU @ndcnoxford.bsky.social 1/6
December 13, 2024 at 4:26 PM