Steven Smeal
@stevenwsmeal.bsky.social
Computational biologist surviving the chaos of grad school and parenting—fueled by coffee.
I'm proud that this work is published and thankful for the excellent computational biology program I am a part of @csbpitt.bsky.social and @cmupittcompbio.bsky.social!
In @natcomms.nature.com, we used robot-controlled cytokine pulses and imaging single receptor complexes and TF dynamics reveal that repeat, dose-conserving stimulation prolongs NEMO/IKK activation and shifts NF-κB dynamics via chromatin remodeling, enabling accurate single-cell models rdcu.be/ezTxF
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...
rdcu.be
August 15, 2025 at 1:46 PM
I'm proud that this work is published and thankful for the excellent computational biology program I am a part of @csbpitt.bsky.social and @cmupittcompbio.bsky.social!
Reposted by Steven Smeal
bioZone isn't just the name of your favorite educational youTube channel, its also an important strategy for geologists
watch on YouTube to support us 👇
youtube.com/shorts/lBfg6...
watch on YouTube to support us 👇
youtube.com/shorts/lBfg6...
August 10, 2025 at 1:05 PM
bioZone isn't just the name of your favorite educational youTube channel, its also an important strategy for geologists
watch on YouTube to support us 👇
youtube.com/shorts/lBfg6...
watch on YouTube to support us 👇
youtube.com/shorts/lBfg6...
Excited to share that my main PhD thesis chapter is published at Nature Communications! The revision included a lot of weekends in the lab, coffee, and a baby convinced that sleep was optional. Despite the chaos, my kids are adorable and sleeping again, and my paper is published!
rdcu.be/ezTxF
rdcu.be/ezTxF
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...
rdcu.be
August 11, 2025 at 3:02 PM
Excited to share that my main PhD thesis chapter is published at Nature Communications! The revision included a lot of weekends in the lab, coffee, and a baby convinced that sleep was optional. Despite the chaos, my kids are adorable and sleeping again, and my paper is published!
rdcu.be/ezTxF
rdcu.be/ezTxF