Sharon Roman (n of 1)
LightNews LightNews
banner
sroman.bsky.social
Sharon Roman (n of 1)
@sroman.bsky.social
85 followers 83 following 120 posts
Using words for better healthcare: MSARD, JNNP, BMJ & MSJ. JNNP Patient Editorial Board, BC Brain Wellness Chair, CMAJ Patient Advisory Panel. MS research explained ↘️ https://tremlettsmsresearchexplained.wordpress.com/
Posts Replies Media Videos
Pinned
sroman.bsky.social
Sharon Roman (n of 1) @sroman.bsky.social · Jun 7
About us tremlettsmsresearchexplained.wordpress.com We believe that research findings should be explained simply, empowering those who stand to benefit from it with knowledge to help guide decisions in care.

Subscribe (free) for real-time #MS research ⬇️

tremlettsmsresearchexplained.wordpress.com
Tremlett's MS Research Explained
Prof. Tremlett's multiple sclerosis (MS) research in plain language
tremlettsmsresearchexplained.wordpress.com
sroman.bsky.social
Can we recognize paediatric #multiplesclerosis earlier?

📣 New study examined age & sex differences in healthcare use up to 16 years before symptom onset. Distinct patterns between age groups & sex were found.

#MSprodrome
It’s explained tremlettsmsresearchexplained.wordpress.com/2026/02/04/h...
Healthcare use before pediatric multiple sclerosis onset differs by age and sex: a nationwide cohort study explained
by Sharon Roman[i] Multiple sclerosis (MS) is a chronic neurological condition typically diagnosed in early adulthood. Paediatric-onset MS (PoMS), defined as MS onset under age 18, makes up approxi…
tremlettsmsresearchexplained.wordpress.com
February 4, 2026 at 6:19 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
📣 Your story matters! Are you living with multiple sclerosis, aged 18+, and in Canada? We need YOU - Help us uncover how genes, environment, and life experiences shape health in MS. Compensation is provided.

Email msepidemiology@nshealth.ca #multiplesclerosis #MSresearch
January 29, 2026 at 1:58 AM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
#healthequity
January 25, 2026 at 5:02 PM
sroman.bsky.social
📣 Your story matters! Are you living with multiple sclerosis, aged 18+, and in Canada? We need YOU - Help us uncover how genes, environment, and life experiences shape health in MS. Compensation is provided.

Email msepidemiology@nshealth.ca #multiplesclerosis #MSresearch
January 29, 2026 at 1:58 AM
sroman.bsky.social
#healthequity
January 25, 2026 at 5:02 PM
sroman.bsky.social
Paediatric data not required for regulatory approval of #MS therapies in Canada. No approval, no funding or access for <18.

Do drug plan age-related restrictions create barriers to treatment & health equity for paediatric-MS?

#change ⬇️

tremlettsmsresearchexplained.wordpress.com/2026/01/22/e...
Equity of access to disease modifying therapy for pediatric multiple sclerosis: a survey of Canadian prescribers explained
by Sharon Roman[i] Approximately 5–10% of people with multiple sclerosis (MS) experience their first symptoms of MS before their 18th  birthday (paediatric-onset MS, or PoMS). Those with PoMS can e…
tremlettsmsresearchexplained.wordpress.com
January 22, 2026 at 7:20 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
#MultipleSclerosis can affect balance, coordination & muscle strength. People with MS have ⬆️ rates of injuries compared to those without MS.

Do injuries form part of the early phase of MS, allowing earlier recognition?

It’s explained ⬇️ tremlettsmsresearchexplained.wordpress.com/2026/01/14/i...
Injury Preceding the Classical Recognition of Multiple Sclerosis: A Population-Based Study Explained
by Sharon Roman[i] Multiple sclerosis (MS), a chronic disabling disease of the central nervous system, can affect balance, coordination, walking and muscle strength, increasing the risk of injury. …
tremlettsmsresearchexplained.wordpress.com
January 14, 2026 at 6:47 PM
sroman.bsky.social
#MultipleSclerosis can affect balance, coordination & muscle strength. People with MS have ⬆️ rates of injuries compared to those without MS.

Do injuries form part of the early phase of MS, allowing earlier recognition?

It’s explained ⬇️ tremlettsmsresearchexplained.wordpress.com/2026/01/14/i...
Injury Preceding the Classical Recognition of Multiple Sclerosis: A Population-Based Study Explained
by Sharon Roman[i] Multiple sclerosis (MS), a chronic disabling disease of the central nervous system, can affect balance, coordination, walking and muscle strength, increasing the risk of injury. …
tremlettsmsresearchexplained.wordpress.com
January 14, 2026 at 6:47 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
#ICYMI early indicators of #MS may begin 6-9 years before onset and differ by sex and age. #MSprodrome.
December 29, 2025 at 8:26 PM
sroman.bsky.social
#ICYMI early indicators of #MS may begin 6-9 years before onset and differ by sex and age. #MSprodrome.
December 29, 2025 at 8:26 PM
sroman.bsky.social
#ICYMI distinct patterns of healthcare use in the 5 years before #MS onset were found raising the possibility for earlier identification. It’s explained ⬇️.
December 29, 2025 at 8:22 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
New population-based study investigated reasons for healthcare use up to 19 years before multiple sclerosis (#MS) onset.

Many symptoms and issues commonly associated with MS may actually begin 6-9 years before classic symptom onset.

It’s tremlettsmsresearchexplained.wordpress.com/2025/12/10/r...
Reasons for healthcare use before onset of multiple sclerosis: a nationwide matched cohort study in Sweden explained
by Sharon Roman[i] Evidence from the past decade of research supports an early phase of multiple sclerosis (MS) known as a prodrome. Early signs and symptoms or health problems not typical of MS oc…
tremlettsmsresearchexplained.wordpress.com
December 10, 2025 at 6:02 PM
sroman.bsky.social
New population-based study investigated reasons for healthcare use up to 19 years before multiple sclerosis (#MS) onset.

Many symptoms and issues commonly associated with MS may actually begin 6-9 years before classic symptom onset.

It’s tremlettsmsresearchexplained.wordpress.com/2025/12/10/r...
Reasons for healthcare use before onset of multiple sclerosis: a nationwide matched cohort study in Sweden explained
by Sharon Roman[i] Evidence from the past decade of research supports an early phase of multiple sclerosis (MS) known as a prodrome. Early signs and symptoms or health problems not typical of MS oc…
tremlettsmsresearchexplained.wordpress.com
December 10, 2025 at 6:02 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
Early recognition of #MS is vital as starting a disease modifying drug may slow progression & prevent disability.

What do the order & reasons for healthcare use in the 5 years before MS is recognized reveal about early detection?

It’s tremlettsmsresearchexplained.wordpress.com/2025/12/09/h...
Heterogeneity in Health Care Pathways Preceding the Classical Recognition of Adult-Onset Multiple Sclerosis: A Multichannel State Sequence Analysis Explained
by Sharon Roman[i] Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system and is the leading cause of non-traumatic disability. Both inflammation and neurodegenera…
tremlettsmsresearchexplained.wordpress.com
December 9, 2025 at 5:02 PM
sroman.bsky.social
Early recognition of #MS is vital as starting a disease modifying drug may slow progression & prevent disability.

What do the order & reasons for healthcare use in the 5 years before MS is recognized reveal about early detection?

It’s tremlettsmsresearchexplained.wordpress.com/2025/12/09/h...
Heterogeneity in Health Care Pathways Preceding the Classical Recognition of Adult-Onset Multiple Sclerosis: A Multichannel State Sequence Analysis Explained
by Sharon Roman[i] Multiple sclerosis (MS) is a chronic, debilitating disease of the central nervous system and is the leading cause of non-traumatic disability. Both inflammation and neurodegenera…
tremlettsmsresearchexplained.wordpress.com
December 9, 2025 at 5:02 PM
sroman.bsky.social
#ICYMI safety reporting in clinical trials of MS therapies has improved, but gaps remain.
December 5, 2025 at 8:33 PM
sroman.bsky.social
What do patterns of healthcare use before #MS recognition reveal?

💥New study of healthcare use 10 years before MS onset found distinct differences linked to future disability. Suggests earlier recognition may be possible.

It’s explained: tremlettsmsresearchexplained.wordpress.com/2025/12/04/i...
Informative patterns of health care utilization preceding the recognition of adult-onset multiple sclerosis: a population-based study explained
by Sharon Roman[i] Multiple sclerosis (MS) is a disabling disease of the central nervous system that affects people differently, often striking in the most productive years of life. Identifying peo…
tremlettsmsresearchexplained.wordpress.com
December 5, 2025 at 8:03 PM
sroman.bsky.social
What do patterns of healthcare use before recognition of #MS reveal?

💥Study of low/medium/high healthcare use 10 years before MS onset found distinct patterns emerged. Differences linked to future disability.

It’s explained ⬇️

tremlettsmsresearchexplained.wordpress.com/2025/12/04/i...
Informative patterns of health care utilization preceding the recognition of adult-onset multiple sclerosis: a population-based study explained
by Sharon Roman[i] Multiple sclerosis (MS) is a disabling disease of the central nervous system that affects people differently, often striking in the most productive years of life. Identifying peo…
tremlettsmsresearchexplained.wordpress.com
December 4, 2025 at 9:20 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
What do we know about the quality of reporting harms in phase III clinical trials of #MS disease modifying therapies?

💥New study evaluated the quality of safety reporting in clinical trial results contributing to FDA drug approval. It’s ⬇️

tremlettsmsresearchexplained.wordpress.com/2025/11/26/s...
Safety reporting quality in multiple sclerosis clinical trials: A review of phase III clinical trials included in FDA approval of disease-modifying treatments explained
by Sharon Roman[i] Phase III clinical trials, testing a new drug or treatment in participants with a specific disease can represent an important step leading to approval by regulatory bodies like t…
tremlettsmsresearchexplained.wordpress.com
November 26, 2025 at 5:50 PM
sroman.bsky.social
What do we know about the quality of reporting harms in phase III clinical trials of #MS disease modifying therapies?

💥New study evaluated the quality of safety reporting in clinical trial results contributing to FDA drug approval. It’s ⬇️

tremlettsmsresearchexplained.wordpress.com/2025/11/26/s...
Safety reporting quality in multiple sclerosis clinical trials: A review of phase III clinical trials included in FDA approval of disease-modifying treatments explained
by Sharon Roman[i] Phase III clinical trials, testing a new drug or treatment in participants with a specific disease can represent an important step leading to approval by regulatory bodies like t…
tremlettsmsresearchexplained.wordpress.com
November 26, 2025 at 5:50 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
Having a psychiatric condition after an #MS diagnosis is associated with greater disability over time.

📣 New study investigated whether psychiatric conditions (e.g. depression, anxiety) before MS onset affects future disability.

It’s ⬇️ tremlettsmsresearchexplained.wordpress.com/2025/10/27/p...
Psychiatric Morbidity During the Multiple Sclerosis Prodrome is Associated with Future Disability Explained
by Sharon Roman[i] Mounting evidence supports an early phase of multiple sclerosis (MS) known as a prodrome. A prodromal phase is an early phase of nonspecific signs and symptoms that occur before …
tremlettsmsresearchexplained.wordpress.com
October 27, 2025 at 11:40 PM
sroman.bsky.social
Having a psychiatric condition after an #MS diagnosis is associated with greater disability over time.

📣 New study investigated whether psychiatric conditions (e.g. depression, anxiety) before MS onset affects future disability.

It’s ⬇️ tremlettsmsresearchexplained.wordpress.com/2025/10/27/p...
Psychiatric Morbidity During the Multiple Sclerosis Prodrome is Associated with Future Disability Explained
by Sharon Roman[i] Mounting evidence supports an early phase of multiple sclerosis (MS) known as a prodrome. A prodromal phase is an early phase of nonspecific signs and symptoms that occur before …
tremlettsmsresearchexplained.wordpress.com
October 27, 2025 at 11:40 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
What are the long-term health effects of interferon-beta use in people with #MS?

💥New population-based drug safety study with up to >20 years of follow-up published.

It’s explained: tremlettsmsresearchexplained.wordpress.com/2025/10/15/r...
Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy explained
by Sharon Roman[i] Interferon-b (Beta) is involved in the body’s response to infection and acts as a crucial part of the immune system. Research has previously suggested that too much interferon-be…
tremlettsmsresearchexplained.wordpress.com
October 21, 2025 at 7:23 PM
sroman.bsky.social
What are the long-term health effects of interferon-beta use in people with #MS?

💥New population-based drug safety study with up to >20 years of follow-up published.

It’s explained: tremlettsmsresearchexplained.wordpress.com/2025/10/15/r...
Risk of cardiovascular and autoimmune disease in people with multiple sclerosis on long-term interferon-β therapy explained
by Sharon Roman[i] Interferon-b (Beta) is involved in the body’s response to infection and acts as a crucial part of the immune system. Research has previously suggested that too much interferon-be…
tremlettsmsresearchexplained.wordpress.com
October 21, 2025 at 7:23 PM
Reposted by Sharon Roman (n of 1)
sroman.bsky.social
Should people radiologically isolated syndrome (RIS) be treated with an #MS therapy?

📣 New study found treatment associated with ⬇️ or delayed risk of developing MS, but with ⬆️ adverse effects.

It’s explained tremlettsmsresearchexplained.wordpress.com/2025/10/16/d...
Disease modifying treatment of radiologically isolated syndrome: a systematic review of the use, efficacy, effectiveness, and safety explained
by Sharon Roman[i] Radiologically isolated syndrome (RIS), first formally defined in 2009, is a distinct condition in the range of central nervous system demyelinating diseases such as multiple scl…
tremlettsmsresearchexplained.wordpress.com
October 16, 2025 at 3:52 PM