Thank you for your encouragement. We were surprised by this finding as well, and it merits further detailed exploration.

👥 𝗧𝗮𝗴𝗴𝗶𝗻𝗴 𝗳𝗲𝘄 𝗹𝗲𝗮𝗱𝗲𝗿𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗲𝗹𝗱 𝘄𝗵𝗼 𝗺𝗮𝘆 𝗳𝗶𝗻𝗱 𝘁𝗵𝗶𝘀 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝗶𝗻𝗴 & 𝘄𝗵𝗼𝘀𝗲 𝘄𝗼𝗿𝗸 𝗶𝗻𝘀𝗽𝗶𝗿𝗲𝗱 𝗼𝘂𝗿𝘀: @ercanlab.bsky.social @sexchrlab.bsky.social @montserrat-anguera.bsky.social @irenemiguel-aliaga.bsky.social @adrianabriscoe.bsky.social @kaessmannlab.bsky.social @shihcheng.bsky.social @avrami.bsky.social

(5/5) Why revisit it now?
MicroPublications make focused results citable, open, and reusable.
If you work on dosage compensation, chromatin, genomics, or Drosophila, take a look 👇
🔗 doi.org/10.17912/mic...
#Drosophila #DosageCompensation #OpenScience

(4/5) Patterns emerged:
• Male reproductive cells → lower compensation
• Neural cells → higher compensation
• Other cells → normal compensation
Known regulators (RoX1 & RoX2) were involved—but couldn’t explain everything.
More biology to uncover 🔍

(3/5) What we found:
X-chromosome regulation spans a spectrum across cell types.
Some cells show lower activity, some are well balanced, and others show higher-than-expected activity.
Not a simple on/off switch.

(2/5) One year ago, we published a microPublication:
“Cell-Type Specific Variation in X-Chromosome Dosage Compensation in Drosophila.”
A short, peer-reviewed study showing X-chromosome regulation isn’t one-size-fits-all. doi.org/10.17912/mic...

(1/5) 🧬 Different organisms solve sex chromosome imbalance in different ways.
* In humans, females turn one X down
* In Drosophila, males turn their single X up.
Same goal: balanced gene expression.

But here’s the interesting question: does this balancing act work the same way in every cell type? 🤔

Prototyping #rshiny apps to native #electron desktop apps:

shinyelectron::export() → #rshinylive conversion → .dmg → Native Mac app

Zero #rstats dependencies for end users! Early days but promising 👀

Using FlyCellAtlas+experiments, we reveal how organs scale via cell size/number diffs: bigger female flight muscles from more myoblasts, larger hearts from bigger cardiomyocytes, & fat body tweaks. Allometric Framework for sex diffs in growth!

#Drosophila #SSD #Allometry #Preprint

Excited to share our new preprint on bioRxiv: "Cell type specific allometry controls sex-differences in Drosophila body size"!

www.biorxiv.org/content/10.1...

𝗛𝗮𝘃𝗲 𝘆𝗼𝘂 𝗲𝘃𝗲𝗿 𝘄𝗼𝗻𝗱𝗲𝗿𝗲𝗱 𝗵𝗼𝘄 𝗺𝗮𝗹𝗲𝘀 𝗶𝗻 𝘀𝗼𝗺𝗲 𝘀𝗽𝗲𝗰𝗶𝗲𝘀 𝗹𝗶𝗸𝗲 𝗵𝘂𝗺𝗮𝗻 𝗮𝗿𝗲 𝗯𝗶𝗴𝗴𝗲𝗿 𝘁𝗵𝗮𝗻 𝗳𝗲𝗺𝗮𝗹𝗲𝘀 𝗲𝘃𝗲𝗻 𝘄𝗵𝗲𝗻 𝘄𝗲 𝗲𝘅𝗰𝗹𝘂𝗱𝗲 𝘁𝗵𝗲 𝘀𝗲𝘅-𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗼𝗿𝗴𝗮𝗻𝘀? 𝗜𝘀 𝗶𝘁 𝗯𝗲𝗰𝗮𝘂𝘀𝗲 𝗼𝗳 𝗯𝗶𝗴𝗴𝗲𝗿 𝗰𝗲𝗹𝗹𝘀 𝗶𝗻 𝗺𝗮𝗹𝗲𝘀, 𝗼𝗿 𝗺𝗮𝗹𝗲𝘀 𝗵𝗮𝘃𝗲 𝗺𝗼𝗿𝗲 𝗰𝗲𝗹𝗹𝘀, 𝗼𝗿 𝗰𝗼𝗺𝗯𝗶𝗻𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝗯𝗼𝘁𝗵? 𝗗𝗼 𝗮𝗹𝗹 𝗼𝗿𝗴𝗮𝗻𝘀 𝗳𝗼𝗹𝗹𝗼𝘄 𝘁𝗵𝗲 𝘀𝗮𝗺𝗲 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝘆?