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Does the future of myeloma treatment belong to trispecific antibodies?

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November 19, 2025 at 2:50 AM
Tafasitamab gets positive CHMP opinion in R/R follicular lymphoma

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Tafasitamab gets positive CHMP opinion in R/R follicular lymphoma
Tafasitamab gets positive CHMP opinion in R/R follicular lymphoma. The opinion is based on results from the phase 3 inMIND trial.
sohoinsider.com
November 17, 2025 at 7:49 PM
"We ... started these studies in the older patients because we were anxious about treating younger patients with chemotherapy-free regimens,"
Dr. Short says in this discussion with Dr. Hagop Kantarjian.

Watch the video:

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November 14, 2025 at 4:42 AM
IDP-023 demonstrates good safety, efficacy in relapsed or refractory myeloma #SITC2025

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IDP-023: Safety, Efficacy in Relapsed/Refractory Myeloma - SOHO Insider
In a first-in-human study, IDP-023 showed promising safety and efficacy in relapsed/refractory multiple myeloma patients.
sohoinsider.com
November 13, 2025 at 1:49 AM
Watch our video interview with María-Victoria Mateos on the DREAMM-7 study on SOHO Insider.
sohoinsider.com/video-interv...
November 8, 2025 at 4:26 PM
DARZALEX FASPRO gets FDA approval to treat HR-SMM, approval based on phase 3 AQUILA study

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The FDA has approved DARZALEX FASPRO®
The FDA has approved DARZALEX FASPRO® as a single-agent therapy for adults with high-risk smoldering multiple myeloma (HR-SMM).
sohoinsider.com
November 7, 2025 at 8:02 PM
US FDA grants interchangeable designation for denosumab-bnht

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US FDA grants interchangeable designation for denosumab-bnht
The US FDA granted interchangeable biosimilar designation to denosumab-bnht (Bomyntra) for patients with multiple myeloma (MM)
sohoinsider.com
November 5, 2025 at 2:33 AM
ICYMI: Drs. Susan O'Brien and Nitin Jain discuss FLAIR trial updates plus emerging BTK degraders in relapsed disease in this SOHO Insider podcast episode:

sohoinsider.com/leukemia/drs...
November 4, 2025 at 2:21 AM
"For a transplant-naive patient, we still can advocate to transplanting these patients if they're fit," Dr. Ibrahim T. Aldoss said in this panel discussion on #ALL with Dr. Elias Jabbour and Aaron Logan.

Watch the video: sohoinsider.com/news/drs-jab...
November 1, 2025 at 2:27 AM
Obesity increases infection risk in CLL for patients treated with a BTKi

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Obesity increases infection risk in CLL
Patients with CLL who have a body mass index (BMI) of 40 or higher are at a greater risk of infection than patients with a normal BMI.
sohoinsider.com
October 31, 2025 at 10:01 PM
ICYMI: Daratumumab, bortezomib, lenalidomide, dexamethasone combo shows efficacy in myeloma across risk groups.
Daratumumab, bortezomib, lenalidomide, dexamethasone combo shows efficacy in myeloma across risk groups
By: Kerri Fitzgerald A study presented by Saad Usmani, MD, MBA, of the Memorial Sloan Kettering Cancer Center, as part of the SOHO 2025 Annual Meeting, showed that the combination of daratumumab,…
sohoinsider.com
October 28, 2025 at 10:27 PM
"People may think physicians become hardened, but the longer you do this, the more you understand what lies ahead for your patients" Gabriela Hobbs said in our Pathways & Perspectives! @massgeneralbrigham.bsky.social

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Pathways & Perspectives with Gabriela Hobbs, MD - SOHO Insider
Dr. Hobbs, MPN lead and clinical director for the Adult Leukemia Service at Massachusetts General Hospital, was born in Mexico City, came to the US for college and her medical training.
sohoinsider.com
October 27, 2025 at 10:42 PM
FDA approves revumenib in relapsed or refractory NMP1-mutated #AML

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FDA approves revumenib in relapsed NMP1-mutated AML
FDA approves revumenib in relapsed or refractory NMP1-mutated AML. Syndax announced the approval in a press release.
sohoinsider.com
October 24, 2025 at 9:10 PM
FDA grants orphan drug designation to MDS investigational therapy ofirnoflast

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FDA has granted orphan drug designation to ofirnoflast
The FDA has granted orphan drug designation to ofirnoflast (HT-6184), an investigational therapy for myelodysplastic symptoms (MDS).
sohoinsider.com
October 23, 2025 at 5:26 PM
SOHO MENA returns to in-person meeting for region’s 3rd meeting
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SOHO MENA returns to in-person meeting for region’s 3rd meeting
SOHO MENA was held Sept. 25–27 in Beirut and marked a return to in-person collaboration after the meeting was held virtually the prior year.
sohoinsider.com
October 22, 2025 at 10:24 PM
Watch @NicholasShortMD with @DrHKantarjian at #SOHO2025 on the future of CAR-T in #ALL.

"I think the future... will be CAR-T cell consolidation...particularly for high-risk patients who otherwise might be referred for stem cell transplant."

Watch now: buff.ly/qvfnjX7
October 21, 2025 at 3:34 PM
This Meet-the-Professor session with Uma Borate, MD, MS,
brought expert insight to #SOHO2025

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Improving Outcomes in CHIP/CCUS with Dr. Borate - SOHO Insider
This Meet-the-Professor session was delivered by Uma Borate, MD, MS, at SOHO 2025 in Houston, Texas, in September 2025.
sohoinsider.com
October 16, 2025 at 9:29 PM
ICYMI: FDA grants orphan drug designation for AK117 (ligufalimab)
FDA grants Orphan Drug Designation for AK117 (ligufalimab)
The US Food and Drug Administration (FDA) has granted Orphan Drug Designation to AK117 (ligufalimab) for the treatment of acute myeloid leukemia (AML). Ligufalimab is a humanized IgG4 monoclonal…
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October 16, 2025 at 8:22 PM