Sarah Jäkel
@sjaekel.bsky.social
Neuroscientist, oligodendrocyte lover, Emmy-Noether junior group leader, mother
I have a question for the research commumity.
I am looking into buying a vibratome to prepare actute organotypic slices from mouse brains and I am unsure which brand to buy. Currently the choice is between Leica and Precisionary Instruments.
Amy recommendations?
I am looking into buying a vibratome to prepare actute organotypic slices from mouse brains and I am unsure which brand to buy. Currently the choice is between Leica and Precisionary Instruments.
Amy recommendations?
April 17, 2025 at 10:22 AM
I have a question for the research commumity.
I am looking into buying a vibratome to prepare actute organotypic slices from mouse brains and I am unsure which brand to buy. Currently the choice is between Leica and Precisionary Instruments.
Amy recommendations?
I am looking into buying a vibratome to prepare actute organotypic slices from mouse brains and I am unsure which brand to buy. Currently the choice is between Leica and Precisionary Instruments.
Amy recommendations?
It was a real pleasure to visit Hamburg and get to knowamy new people!
On 19 February the first #HertieNetworkLecture took place, organized by the #HertieNeuroSci fellows Hamburg. @sjaekel.bsky.social from Munich talked about “Using human brain tissue to study oligodendrocyte pathology in Alzheimer's disease”. What a great start of the #HertieNetworkLecture Series!
March 10, 2025 at 2:02 PM
It was a real pleasure to visit Hamburg and get to knowamy new people!
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology?
The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...
journals.plos.org
January 8, 2025 at 8:15 PM
Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction.
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
This work was a huge collaborative effort, it is a brilliant resource for many researchers, and I am really glad to see this out!
Delighted to see this research now out. Thank you to @willmacnair.bsky.social, @gocastelobranco.bsky.social, @rebeccakssmith.bsky.social, @sjaekel.bsky.social, charles ffrench-Constant, Dheeraj Malhotra and many more not on bluesky for making it happen.
December 20, 2024 at 5:44 PM
This work was a huge collaborative effort, it is a brilliant resource for many researchers, and I am really glad to see this out!
The first paper of the Jäkel lab is out!
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...
Impact of fixation duration on messenger RNA detectability in human formalin-fixed paraffin embedded brain tissue
Hurler et al. performed RNAScope on post-mortem human brain tissue and found mRNA signal detection to be highly dependent on fixation time. Considering the
doi.org
November 29, 2024 at 5:54 AM
The first paper of the Jäkel lab is out!
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...
We have shown that the RNA detection in human FFPE brain tissue significantly changes with fixation time. Chose your tissue well before doing an experiment!
doi.org/10.1093/brai...