Siavash
@siavashk.bsky.social
UCLA faculty; interested in histones, metabolism, and soccer.
Thank you for all the support! I look forward to contributing to the success of ASBMB and our broader community.
Sharing the news with newly elected leaders who are on Bluesky!
• Congratulations to @siavashk.bsky.social & @christinedunham.bsky.social.
• Congratulations to @siavashk.bsky.social & @christinedunham.bsky.social.
June 26, 2025 at 1:08 PM
Thank you for all the support! I look forward to contributing to the success of ASBMB and our broader community.
New paper out! 📢 We show that amino acid restriction triggers genome-wide H4K20me1 loss and MYC activation—priming cells for rapid protein synthesis upon refeeding. A chromatin-based strategy for surviving nutrient stress with implications for MYC-driven cancers.
Coordinated histone methylation loss and MYC activation promote translational capacity under amino acid restriction - Cancer & Metabolism
Background Cells adapt to nutrient fluctuations through both signaling and epigenetic mechanisms. While amino acid (AA) deprivation is known to suppress protein synthesis via mTORC1 inactivation, the ...
cancerandmetabolism.biomedcentral.com
June 16, 2025 at 6:32 PM
New paper out! 📢 We show that amino acid restriction triggers genome-wide H4K20me1 loss and MYC activation—priming cells for rapid protein synthesis upon refeeding. A chromatin-based strategy for surviving nutrient stress with implications for MYC-driven cancers.
If you’ve struggled making a creamy Cacio e Pepe sauce, science is here to help you!
pubs.aip.org/aip/pof/arti...
pubs.aip.org/aip/pof/arti...
Phase behavior of Cacio e Pepe sauce
“Pasta alla Cacio e pepe” is a traditional Italian dish made with pasta, pecorino cheese, and pepper. Despite its simple ingredient list, achieving the perfect
pubs.aip.org
April 30, 2025 at 3:23 AM
If you’ve struggled making a creamy Cacio e Pepe sauce, science is here to help you!
pubs.aip.org/aip/pof/arti...
pubs.aip.org/aip/pof/arti...
Liverpool @lfcr.bsky.social are champions ⚽️🥇🏆🥇⚽️
April 27, 2025 at 7:37 PM
Liverpool @lfcr.bsky.social are champions ⚽️🥇🏆🥇⚽️
Learn about the remarkable life and career of Sabeeha Merchant, an incredible scientist who was my biochem teacher as an undergrad and is now an invaluable mentor and collaborator.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The Elements of Life, Photosynthesis and Genomics
I am a Professor of Biochemistry, Biophysics and Structural Biology and Plant and Microbial Biology at the University of California in Berkeley. I was…
www.sciencedirect.com
April 22, 2025 at 11:04 PM
Learn about the remarkable life and career of Sabeeha Merchant, an incredible scientist who was my biochem teacher as an undergrad and is now an invaluable mentor and collaborator.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae
Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in yeast.
www.science.org
April 11, 2025 at 9:43 PM
Ever wondered what the lonely histone H3C110 does? We found that it’s lost in many fungi. Adding it back boosts histone H3 copper reductase activity, rescues iron defects and modulates lifespan, suggesting an evolutionary tradeoff between these effects.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...