Shelly Scribner
@shellyscrib.bsky.social
Bioinformatics Scientist at Theiagen Genomics. Cat lover and broad-spectrum nerd based in Pittsburgh, PA.
Did you know that it only takes one spontaneous mutation in your bacterial culture to activate a phage, and trigger a subsequent cascade of bacterial/phage evolution? 🧪 Curious how you could detect similar events in your experiments? Check out Nanami’s work!
Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons
@shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...
@shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...
Filamentous cheater phages drive bacterial and phage populations to lower fitness
Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...
www.biorxiv.org
April 2, 2025 at 4:58 PM
Did you know that it only takes one spontaneous mutation in your bacterial culture to activate a phage, and trigger a subsequent cascade of bacterial/phage evolution? 🧪 Curious how you could detect similar events in your experiments? Check out Nanami’s work!
Reposted by Shelly Scribner
Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium - Nature Microbiology
Genomic and functional analyses of healthcare-associated vancomycin-resistant Enterococcus faecium reveal that bacteriocin T8 is enriched in emergent lineages and provides a competitive advantage in v...
www.nature.com
March 21, 2025 at 1:46 PM
Excited to share our latest, out today in @naturemicrobiol.bsky.social Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium www.nature.com/articles/s41... @idpittstop.bsky.social
Reposted by Shelly Scribner
CDC's "disease detectives" halved as part of DOGE cuts at health agencies www.cbsnews.com/news/cdc-dis...
CDC's "disease detectives" halved as part of DOGE cuts at health agencies
More than 1 in 10 of the health agency's workers are being let go, including an entire new class of CDC Epidemic Intelligence Service officers.
www.cbsnews.com
February 14, 2025 at 7:28 PM
CDC's "disease detectives" halved as part of DOGE cuts at health agencies www.cbsnews.com/news/cdc-dis...
Reposted by Shelly Scribner
Many researchers are still waiting on Notice of Awards to start their work. Delays (or worse, withdrawals) don’t just pause projects—they ripple through the entire system, stalling discoveries and breakthroughs.
Cutting off research funding means cutting off progress.
#PublicHealth
Cutting off research funding means cutting off progress.
#PublicHealth
NEW: N.I.H. medical research grants are ⚠️ $1 billion dollars ⚠️ behind this point hit last year -- and hundreds of millions behind prior years amid Trump administration chaos. w/ @teddyrosenbluth.bsky.social
www.nytimes.com/2025/02/14/h...
www.nytimes.com/2025/02/14/h...
NIH Research Grants Lag Behind Last Year by $1 Billion
After weeks of disruption to scientific federal grants, the National Institutes of Health has fallen behind in funding research into treatments for deadly diseases.
www.nytimes.com
February 14, 2025 at 7:48 PM
Many researchers are still waiting on Notice of Awards to start their work. Delays (or worse, withdrawals) don’t just pause projects—they ripple through the entire system, stalling discoveries and breakthroughs.
Cutting off research funding means cutting off progress.
#PublicHealth
Cutting off research funding means cutting off progress.
#PublicHealth
Reposted by Shelly Scribner
Since 1991, the NIH Science Education Partnership Award (SEPA) is dedicated to K-12 students & funds innovative STEM educational projects.
It supports our EvolvingSTEM program that engages >1500 students/yr in authentic research.
🚨Its Program Announcement (PAR-23-137) is now GONE.😡
nihsepa.org
It supports our EvolvingSTEM program that engages >1500 students/yr in authentic research.
🚨Its Program Announcement (PAR-23-137) is now GONE.😡
nihsepa.org
Home
The Science Education Partnership Award (SEPA) program funds innovative science, technology, engineering, and mathematics (STEM) and Informal Science Education (ISE) educational projects for pre-kinde
nihsepa.org
January 31, 2025 at 2:42 AM
Since 1991, the NIH Science Education Partnership Award (SEPA) is dedicated to K-12 students & funds innovative STEM educational projects.
It supports our EvolvingSTEM program that engages >1500 students/yr in authentic research.
🚨Its Program Announcement (PAR-23-137) is now GONE.😡
nihsepa.org
It supports our EvolvingSTEM program that engages >1500 students/yr in authentic research.
🚨Its Program Announcement (PAR-23-137) is now GONE.😡
nihsepa.org
Reposted by Shelly Scribner
Do you make core genome alignments for phylogenomics? Mona Taouk and I explored how including sites with some missing data (a soft core) can improve analysis, especially for large datasets.
www.microbiologyresearch.org/content/jour...
(1/4)
www.microbiologyresearch.org/content/jour...
(1/4)
Exploring SNP filtering strategies: the influence of strict vs soft core
Phylogenetic analyses are crucial for understanding microbial evolution and infectious disease transmission. Bacterial phylogenies are often inferred from SNP alignments, with SNPs as the fundamental ...
www.microbiologyresearch.org
January 20, 2025 at 10:24 PM
Do you make core genome alignments for phylogenomics? Mona Taouk and I explored how including sites with some missing data (a soft core) can improve analysis, especially for large datasets.
www.microbiologyresearch.org/content/jour...
(1/4)
www.microbiologyresearch.org/content/jour...
(1/4)
Reposted by Shelly Scribner
I'm incredibly honored by this opportunity to serve as President-Elect of @asm.org starting this summer. Looking forward to working with the Board, ASM leadership ,and staff to help advance the microbial sciences. I'm also glad to share my Vision statement, please join us!
asm.org/Press-Releas...
asm.org/Press-Releas...
January 21, 2025 at 8:51 PM
I'm incredibly honored by this opportunity to serve as President-Elect of @asm.org starting this summer. Looking forward to working with the Board, ASM leadership ,and staff to help advance the microbial sciences. I'm also glad to share my Vision statement, please join us!
asm.org/Press-Releas...
asm.org/Press-Releas...
Reposted by Shelly Scribner
I'm putting together a Microbial Bioinformatics starter pack to help get everyone connected in our community. Let me know if there are any bluesky users to be added and share so that twitter refugees can tune back in to the fantastic world microbes go.bsky.app/3ezLo7e
January 10, 2025 at 9:38 AM
I'm putting together a Microbial Bioinformatics starter pack to help get everyone connected in our community. Let me know if there are any bluesky users to be added and share so that twitter refugees can tune back in to the fantastic world microbes go.bsky.app/3ezLo7e
Reposted by Shelly Scribner
Ryan Wick has tested out the latest kits and basecalling for bacterial genome assembly:
rrwick.github.io/2023/10/24/o...
At assembly error rates like this I start to begin wondering what is "ground truth"
rrwick.github.io/2023/10/24/o...
At assembly error rates like this I start to begin wondering what is "ground truth"
October 25, 2023 at 2:17 PM
Ryan Wick has tested out the latest kits and basecalling for bacterial genome assembly:
rrwick.github.io/2023/10/24/o...
At assembly error rates like this I start to begin wondering what is "ground truth"
rrwick.github.io/2023/10/24/o...
At assembly error rates like this I start to begin wondering what is "ground truth"