Shashank Pritam
@shashankpritam.bsky.social
shuh-SHAHNK | PhD Candidate, Computational Biologist, Ailurophile :)
Pinned
Reposted by Shashank Pritam
My awesome grad student Shashank and I wrote this paper trying to look at broader patterns of HT in TEs. HT is happening everywhere! DNA transposons jump further than other classes! www.biorxiv.org/content/10.1...
Recent horizontal transfer of transposable elements in Drosophila
Transposable elements (TEs) are genetic elements also known as "jumping genes" that increase their copy numbers within a host through various mechanisms of transposition. TEs can also move between spe...
www.biorxiv.org
October 31, 2025 at 3:58 PM
My awesome grad student Shashank and I wrote this paper trying to look at broader patterns of HT in TEs. HT is happening everywhere! DNA transposons jump further than other classes! www.biorxiv.org/content/10.1...
GOATed:
Mezzanine (Deluxe) - Album by Massive Attack
Mezzanine is the third studio album by English electronic music group Massive Attack, released on 20 April 1998 by Circa and Virgin Records. For the album, the group began to explore a darker aestheti...
music.youtube.com
October 6, 2025 at 9:53 PM
GOATed:
Reposted by Shashank Pritam
Reposted by Shashank Pritam
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
High-resolution metagenome assembly for modern long reads with myloasm https://www.biorxiv.org/content/10.1101/2025.09.05.674543v1
September 7, 2025 at 11:35 PM
Preprint out for myloasm, our new nanopore / HiFi metagenome assembler!
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Nanopore's getting accurate, but
1. Can this lead to better metagenome assemblies?
2. How, algorithmically, to leverage them?
with co-author Max Marin @mgmarin.bsky.social, supervised by Heng Li @lh3lh3.bsky.social
1 / N
Imagine Sisyphus on the Ship of Theseus! hehe, btw highly recommend this 2012 movie by Anand Gandhi.
September 7, 2025 at 12:58 PM
Imagine Sisyphus on the Ship of Theseus! hehe, btw highly recommend this 2012 movie by Anand Gandhi.
Reposted by Shashank Pritam
Tenure seminar, done!
Time to learn about transposons with @signor-molevol.bsky.social
September 5, 2025 at 10:48 PM
Tenure seminar, done!
Reposted by Shashank Pritam
@tangled.sh search interface if you need it. tangled-search.bigmoves.deno.net. Example of what you can build with Slices (an appview builder) and the power of the #atprotocol. Still working through all the details but waitlist and beta for Slices are coming soon!
September 4, 2025 at 7:41 PM
@tangled.sh search interface if you need it. tangled-search.bigmoves.deno.net. Example of what you can build with Slices (an appview builder) and the power of the #atprotocol. Still working through all the details but waitlist and beta for Slices are coming soon!
Reposted by Shashank Pritam
Germline defence from TEs largely relies on piRNAs. Yet, @divyaselvaraju.bsky.social and I monitored a P-element invasion in Drosophila that was stopped by an internally deleted copy, no host intervention required!
doi.org/10.1371/jour...
Many thanks to @rpianezza.bsky.social & @rokofler.bsky.social
doi.org/10.1371/jour...
Many thanks to @rpianezza.bsky.social & @rokofler.bsky.social
Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence
Author summary Transposable elements (TEs) are short, self-replicating DNA sequences found in nearly all genomes. While they can be harmful to their hosts, many organisms have evolved defence systems,...
journals.plos.org
August 28, 2025 at 1:27 PM
Germline defence from TEs largely relies on piRNAs. Yet, @divyaselvaraju.bsky.social and I monitored a P-element invasion in Drosophila that was stopped by an internally deleted copy, no host intervention required!
doi.org/10.1371/jour...
Many thanks to @rpianezza.bsky.social & @rokofler.bsky.social
doi.org/10.1371/jour...
Many thanks to @rpianezza.bsky.social & @rokofler.bsky.social
Reposted by Shashank Pritam
The Signor lab is loving our new lab shwag, designed by the ever wonderful @nepeteaa.bsky.social
August 19, 2025 at 3:58 PM
The Signor lab is loving our new lab shwag, designed by the ever wonderful @nepeteaa.bsky.social
Reposted by Shashank Pritam
@shashankpritam.bsky.social first research paper on the effect of insertion bias on transposon fitness!! With @almoroscarpa.bsky.social and @rokofler.bsky.social link.springer.com/article/10.1...
The impact of insertion bias into piRNA clusters on the invasion of transposable elements - BMC Biology
Background In our current understanding of transposable element (TE) invasions, TEs move freely until they accidentally insert into a piRNA cluster, where they are silenced by the production of piRNA ...
link.springer.com
August 15, 2025 at 4:10 PM
@shashankpritam.bsky.social first research paper on the effect of insertion bias on transposon fitness!! With @almoroscarpa.bsky.social and @rokofler.bsky.social link.springer.com/article/10.1...
Reposted by Shashank Pritam
Look at this prince
November 30, 2024 at 1:33 PM
Look at this prince
Reposted by Shashank Pritam
My graduate student shashank and I wrote this cool review on the evolution of transposon defense. Come for pirna cluster evolution stay for wild theories!
Evolution of piRNA-guided defense against transposable elements
Transposable elements (TEs) shape every aspect of genome biology, influencing genome stability, size, and organismal fitness. Following the 2007 disco…
www.sciencedirect.com
December 12, 2024 at 11:43 PM
My graduate student shashank and I wrote this cool review on the evolution of transposon defense. Come for pirna cluster evolution stay for wild theories!
Iguana skeleton
June 20, 2024 at 11:13 PM
Iguana skeleton
