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sciencealwayswins.bsky.social
Joel Credle
@sciencealwayswins.bsky.social
98 followers 340 following 5 posts
Scientific Co-founder @ Infinity Bio & Portal Biosciences | Director of R & D | Antibody & RNA Analysis Solutions
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Reposted by Joel Credle
infinitybioinc.bsky.social
𝗖𝗼𝗵𝗼𝗿𝘁 𝘀𝘁𝘂𝗱𝘆 𝗼𝗳 𝘁𝗵𝗲 𝘄𝗲𝗲𝗸 “𝗦𝗼𝗰𝗶𝗮𝗹 𝗱𝗶𝘀𝗮𝗱𝘃𝗮𝗻𝘁𝗮𝗴𝗲 𝗮𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗲𝘀 𝗮𝗴𝗶𝗻𝗴” Nature Med 2025 by @mikakivimaki.bsky.social & Joni V. Lindbohm links 14-protein plasma signatures to accelerated aging & disease risk via immune pathways.
#ProteomicSignatures #AgingBiomarkers #Reactome
www.nature.com/articles/s41...
April 30, 2025 at 4:48 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Cohort Study of the Week: Oh & Wyss-Coray from Stanford University show in Nature Medicine that the CSF YWHAG:NPTX2 ratio predicts cognitive decline years before Alzheimer’s symptoms, outperforming traditional biomarkers.

#AlzheimerDisease #CSFBiomarkers #Proteomics

www.nature.com/articles/s41...
May 6, 2025 at 4:42 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
🌟 Cohort Study of the Week! 🌟 From derosalab.bsky.social Gut dysbiosis linked to survival in 955 cancer patients. The balance of Akkermansia & sMAdCAM-1 are crucial for prognosis. Important #PrecisionOncology!

pubmed.ncbi.nlm.nih.gov/40189749/
#CancerResearch #Microbiome #Oncology
May 21, 2025 at 7:47 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Infinity Bio’s Cohort of the Week: Bos & Zambrana find inapparent DENV; Kasbergen & Koopmans track ZIKV. Multiplex serology reveals infection dynamics.
www.thelancet.com/journals/lan...
academic.oup.com/jid/advance-...
June 10, 2025 at 4:43 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
#CohortOfTheWeek A pivotal study on the association of anti-viral antibodies & neural autoantibodies in psychiatric disorders. Analyzing CSF/serum from patients, they found a significant link, suggesting CNS viral infection could trigger autoantibody generation
pubmed.ncbi.nlm.nih.gov/40382511/
July 1, 2025 at 6:19 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
New #CohortOfTheWeek from Infinity Bio! Latent #EBV infection surprisingly impacts #Type1Diabetes treatment efficacy! Yale researchers found EBV-positive patients show improved responses to teplizumab. #Immunology #AutoimmuneDisease
[Link: www.nature.com/articles/s41...
July 8, 2025 at 6:41 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Cohort study: “Plasma proteome variation and its genetic determinants in children and adolescents” by @liliniu.bsky.social Simon Rasmussen, Torben Hansen, mannlab.bsky.social maps 1,200+ proteins & genetic drivers in 2,100+ youth
#MassSpectroscopy #Plasma #Proteomics www.nature.com/articles/s41...
Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics
This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.
www.nature.com
May 13, 2025 at 5:24 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Cohort study of the week “Proteomic changes upon treatment with semaglutide in individuals with obesity” (Nature Medicine Jan 2025) by Lasse Maretty, Abd Tahrani & Milan Geybels reveals proteomic shifts in STEP 1 & 2 trials #Semaglutide #GLP1ReceptorAgonist #Proteomics www.nature.com/articles/s41...
April 22, 2025 at 6:04 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
𝗖𝗼𝗵𝗼𝗿𝘁 𝘀𝘁𝘂𝗱𝘆 𝗼𝗳 𝘁𝗵𝗲 𝘄𝗲𝗲𝗸: “Preclinical Protein Signatures of Crohn’s Disease and Ulcerative Colitis” by Dr. Oscar Grännö & Jonas Halfvarson reveals blood-based proteomic biomarkers that precede IBD diagnosis.

#IBDResearch #Proteomics #Biomarkers

lnkd.in/eTr8TWtH
April 15, 2025 at 5:39 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Cohort study: "Multi-cohort CSF proteomics identifies robust molecular signatures in Alzheimer's disease" by Muhammad Ali & Carlos Cruchaga. Large-scale analysis uncovers molecular signatures associated with Alzheimer's.
#Proteomic #Antibody #EarlyDetectionAD
www.cell.com/neuron/fullt...
April 8, 2025 at 5:29 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
The first authors developed an integrative model, Mal-ID.To address a gap in current diagnostic medical practices, which do not yet utilize the adaptive immune system’s B cell receptor (BCR) and T cell receptor (TCR) sequences in diagnosis.
April 2, 2025 at 3:31 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Cohort study of the week: Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases by Heinz Wiendl, Gerd Meyer zu Hörste, & Michael Heming. This analysis of cerebrospinal fluid & blood samples explores immune cell profiles across neurological conditions.
https://onlinelibrary.wiley.com/doi/10.1002/ana.27157
March 25, 2025 at 4:53 PM
Reposted by Joel Credle
anshulkundaje.bsky.social
I've temporarily revived my X account. No science or chit chat. Purely to boost the resistance against the misinformation and anti science propaganda.
February 15, 2025 at 4:34 AM
Reposted by Joel Credle
infinitybioinc.bsky.social
Interesting study by Kari E. North & Jennifer E. Below from @uncpublichealth.bsky.social & vumedicine.bsky.social ChenHungHsin & Heather M. Highland uncover IL4R, LILRA5 & OSM as inflammatory drivers in severe obesity via #multiomics. Could #antibody profiling add deeper immune insights? #Inspiring
Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
Chen et al. analyzed gene expression in Hispanic Latino individuals with severe obesity (BMI ≥40 kg/m2) in comparison to controls, following up their 124 findings with subcutaneous adipose tissue expr...
www.cell.com
March 14, 2025 at 2:00 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
👋 We're Infinity Bio Inc, and We Read Antibodies 🔬 Decoding the antibody reactome with our unique MIPSA tech: complete immune target panels, cutting-edge data science, and top-notch quality. Learn more: www.infinitybio.com #antibodies #immunology #proteomics #datascience #MIPSA
Antibody Profiling Services | Infinity Bio
Learn how Infinity Bio's antibody profiling services can detail the reactome in your samples.
www.infinitybio.com
March 4, 2025 at 8:52 PM
Reposted by Joel Credle
infinitybioinc.bsky.social
Big news for #preclinical #research! 🐭 Unveiling MuSIGHT™: comprehensive mouse autoantibody analysis powered by MIPSA! Explore the entire mouse proteome with 273,000+ sequences. Learn more & advance your #immunology work: businesswire.com/news/home/20... & infinitybio.com/musight/ #antibody #immune
Infinity Bio Launches Comprehensive Mouse Antibody Reactome Profiling Service
Infinity Bio is pleased to announce the release of their MuSIGHT™ mouse autoantibody reactome service offering. Defining an animal’s autoantibody reac
businesswire.com
March 5, 2025 at 1:55 PM
Reposted by Joel Credle
summitos.bsky.social
🔬 Join Ben Larman, CSO of Infinity Bio, to explore frameworks transforming biotech. Discover DNA barcoding, AI-driven breakthroughs, and the art of impactful storytelling.

🎙️ Listen now! https://buff.ly/4121uj0

#Biotech #AI #Innovation #Leadership
February 7, 2025 at 2:00 PM
sciencealwayswins.bsky.social
Another amazing paper out of Ben Larman's lab out of JHU-SOM

“Exciting progress in spatial transcriptomics! A new method, LISH-LnR, enables detailed high-plex mRNA analysis in FFPE. #Biotech #Research #SpatialTranscriptomics

www.biorxiv.org/content/10.1...
Dual Probe Ligation In Situ Hybridization with Rolling-Circle Amplification for High-Plex Spatial Transcriptomics
New biological insights are increasingly dependent upon a deeper understanding of tissue architectures. Critical to such studies are spatial transcriptomics technologies, especially those amenable to ...
www.biorxiv.org
January 25, 2025 at 5:24 PM
Reposted by Joel Credle
disavowtrump20.bsky.social
Hillary ran so that future women could win.

She took all the arrows, fought the good fight, and put 65 million cracks in that glass ceiling.

No one is more deserving of the Presidential Medal of Freedom. Congratulations, Secretary Clinton. 💙
January 5, 2025 at 3:56 PM
Reposted by Joel Credle
kylegriffin1.bsky.social
President Biden just announced the newest recipients of the Presidential Medal of Freedom. Names include:

Hillary Clinton
José Andrés
Jane Goodall
George Soros
Earvin "Magic" Johnson
Bono
Fannie Lou Hammer
Bill Nye
George Romney
Denzel Washington
Anna Wintour
January 4, 2025 at 10:20 AM
sciencealwayswins.bsky.social
#Vaccines. www.washingtonpost.com/wellness/202...
Need we say more about the benefits of vaccines.
Cervical cancer deaths drop among younger women; study credits HPV vaccine
The HPV vaccine has led to a significant drop in cervical cancer deaths among younger women, with a 62 percent decline in mortality over the last decade.
www.washingtonpost.com
January 4, 2025 at 6:34 PM
sciencealwayswins.bsky.social
www.who.int/news/item/24...
For those who don't know or refuse to accept, here are some facts about #vaccines.
Global immunization efforts have saved at least 154 million lives over the past 50 years
A major landmark study reveals that global immunization efforts have saved an estimated 154 million lives – or the equivalent of 6 lives every minute of every year – over the past 50 years. The vast m...
www.who.int
January 4, 2025 at 6:32 PM
sciencealwayswins.bsky.social
With the new administration taking office and the potential for RFK Jr., who is not a #scientist, to oversee the #HHS including the #CDC, #FDA, #NIH, and Disease Registry, #ARPA, and several other key agencies—I wanted to preserve certain information that may soon become less accessible.
January 4, 2025 at 6:30 PM
sciencealwayswins.bsky.social
New to Bluesky and haven't posted anything yet but here it goes as we crash into 2025.......
January 4, 2025 at 6:21 PM
Reposted by Joel Credle
disavowtrump20.bsky.social
This is Ronald Rowe, the Director of the United States Secret Service and a 30-year veteran of law enforcement. Today, GOP Rep. Pat Fallon politicized the victims of 9/11 to launch a disgusting attack against him.

REPOST if you stand with Director Rowe against the GOP!
December 5, 2024 at 6:36 PM