SCBRMSinai
@scbrm.bsky.social
Department of Stem Cell Biology and Regenerative Medicine at ISMMS
In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila
Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow ( arr ) in Drosophila , is the obligat...
www.biorxiv.org
October 21, 2025 at 2:49 PM
In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Two exciting preprints from @mlodziklab.bsky.social lab. In the first preprint, Vuong and Mlodzik describe a novel, essential factor for bcatenin translocation to the nucleus, a big step forward to understand nuclear bcatenin localization. www.biorxiv.org/content/10.1...
A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling
Wingless (Wg)/Wnt signaling is critical throughout development and tissue homeostasis and associated with many disease states. Canonical Wg/Wnt-signaling is mediated by β-catenin (Arm in Drosophila ) ...
www.biorxiv.org
October 21, 2025 at 2:45 PM
Two exciting preprints from @mlodziklab.bsky.social lab. In the first preprint, Vuong and Mlodzik describe a novel, essential factor for bcatenin translocation to the nucleus, a big step forward to understand nuclear bcatenin localization. www.biorxiv.org/content/10.1...
Reposted by SCBRMSinai
Our values and resolve are only strengthened by recent events.
February 11, 2025 at 10:51 PM
Our values and resolve are only strengthened by recent events.