Sazanov Lab
@sazanovlab.bsky.social
Professor, Institute of Science and Technology Austria
Visiting Professor, Imperial College London
Structure/function of molecular machines and membrane proteins
cryoEM
Bioenergetics
Fellow of Royal Society and EMBO
Visiting Professor, Imperial College London
Structure/function of molecular machines and membrane proteins
cryoEM
Bioenergetics
Fellow of Royal Society and EMBO
Reposted by Sazanov Lab
Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at/registration/
#cryoEM
#cryoEM
October 10, 2025 at 10:04 AM
Join us for the Austrian Cryo-EM Symposium from Nov 11–12 at ISTA! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at/registration/
#cryoEM
#cryoEM
Reposted by Sazanov Lab
Apple is entering the protein folding arena.
SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
September 25, 2025 at 9:02 AM
Apple is entering the protein folding arena.
SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
How the twin-arginine translocase (Tat) system manages to transport folded proteins across membranes without any leaks? To answer this fundamental question we solved the first structure of TatB3C3 complex with bound cargo. Please check out new preprint!
t.co/962Kj9pt6F
t.co/962Kj9pt6F
https://www.biorxiv.org/content/10.1101/2025.09.16.676506v1
t.co
September 18, 2025 at 5:35 PM
How the twin-arginine translocase (Tat) system manages to transport folded proteins across membranes without any leaks? To answer this fundamental question we solved the first structure of TatB3C3 complex with bound cargo. Please check out new preprint!
t.co/962Kj9pt6F
t.co/962Kj9pt6F
Happy to share new preprint from our collaboration with Peter Nixon group from Imperial College. New insights into Photosystem II assembly/disassembly.
t.co/Qac81hZ9kp
t.co/Qac81hZ9kp
https://www.biorxiv.org/content/10.1101/2025.07.17.665390v1
t.co
July 20, 2025 at 2:20 PM
Happy to share new preprint from our collaboration with Peter Nixon group from Imperial College. New insights into Photosystem II assembly/disassembly.
t.co/Qac81hZ9kp
t.co/Qac81hZ9kp
Reposted by Sazanov Lab
Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose.
A crucial contribution to the debate about the mechanisms of action of #metformin.
#metabolism #glucose
doi.org/10.1126/scia...
A crucial contribution to the debate about the mechanisms of action of #metformin.
#metabolism #glucose
doi.org/10.1126/scia...
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
doi.org
January 5, 2025 at 2:27 AM
Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose.
A crucial contribution to the debate about the mechanisms of action of #metformin.
#metabolism #glucose
doi.org/10.1126/scia...
A crucial contribution to the debate about the mechanisms of action of #metformin.
#metabolism #glucose
doi.org/10.1126/scia...
Árbol del Tule, Montezuma cypress near Oaxaca in Mexico is amazing. It is the biggest tree in the world by trunk width (14 m diameter). How just a few green needles maintain this tree over 2000 years is a mystery to me.
January 5, 2025 at 3:23 PM
Árbol del Tule, Montezuma cypress near Oaxaca in Mexico is amazing. It is the biggest tree in the world by trunk width (14 m diameter). How just a few green needles maintain this tree over 2000 years is a mystery to me.
Reposted by Sazanov Lab
Interested in a doing a PhD at Institute of Science and Technology Austria (ISTA)?
Exciting research in phys, chem, structural biology, math, neuro, earth sciences, computer sciences and more...
Sign up here for the virtual student open day Nov 20, 2024.
phd.pages.ista.ac.at/student-open...
Exciting research in phys, chem, structural biology, math, neuro, earth sciences, computer sciences and more...
Sign up here for the virtual student open day Nov 20, 2024.
phd.pages.ista.ac.at/student-open...
Virtual Student Open Day 2024
Each year, the Institute of Science and Technology Austria (ISTA) opens its doors to give prospective PhD and internship candidates an insight into what it is like to study and do research at the inst...
phd.pages.ista.ac.at
November 18, 2024 at 8:32 PM
Interested in a doing a PhD at Institute of Science and Technology Austria (ISTA)?
Exciting research in phys, chem, structural biology, math, neuro, earth sciences, computer sciences and more...
Sign up here for the virtual student open day Nov 20, 2024.
phd.pages.ista.ac.at/student-open...
Exciting research in phys, chem, structural biology, math, neuro, earth sciences, computer sciences and more...
Sign up here for the virtual student open day Nov 20, 2024.
phd.pages.ista.ac.at/student-open...
Hi, I heard there is cryo-EM starter pack here - how do I join? Many thanks!
November 18, 2024 at 1:05 PM
Hi, I heard there is cryo-EM starter pack here - how do I join? Many thanks!