Rüegg Lab
@ruegglab.bsky.social
Reposted by Rüegg Lab
We’re excited to launch our Research Highlight Series! First up: an in-depth Q&A with Dr. Daniel Ham from @ruegglab.bsky.social on his latest @natcomms.nature.com paper, and insights into muscle biology, research, and more. #MyoBlue
Read the interview
aurorascientific.com/research-hig...
Read the interview
aurorascientific.com/research-hig...
August 12, 2025 at 2:38 PM
We’re excited to launch our Research Highlight Series! First up: an in-depth Q&A with Dr. Daniel Ham from @ruegglab.bsky.social on his latest @natcomms.nature.com paper, and insights into muscle biology, research, and more. #MyoBlue
Read the interview
aurorascientific.com/research-hig...
Read the interview
aurorascientific.com/research-hig...
In our latest preprint, we show that activated muscle stem cells secrete laminin-α2 into their niche — and that the loss of this process intrinsically impairs their regenerative capacity in LAMA2-related muscular dystrophy:
doi.org/10.1101/2025...
doi.org/10.1101/2025...
June 28, 2025 at 2:43 PM
In our latest preprint, we show that activated muscle stem cells secrete laminin-α2 into their niche — and that the loss of this process intrinsically impairs their regenerative capacity in LAMA2-related muscular dystrophy:
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Rüegg Lab
New study by @ruegglab.bsky.social challenges previous view about the muscle growth factor #Myc! The protein is dispensable for #musclegrowth. High Myc levels disrupt muscle fiber structure & function. @unibas.ch @snsf-ch.bsky.social @naturecomms.bsky.social www.biozentrum.unibas.ch/news/detail/...
New insights challenge previous views about a muscle growth factor
The protein Myc has long been thought to support skeletal muscle growth. Prof. Markus Rüegg's team at the Biozentrum provides compelling evidence that Myc in muscle fibers is dispensable for muscle gr...
www.biozentrum.unibas.ch
April 14, 2025 at 10:29 AM
New study by @ruegglab.bsky.social challenges previous view about the muscle growth factor #Myc! The protein is dispensable for #musclegrowth. High Myc levels disrupt muscle fiber structure & function. @unibas.ch @snsf-ch.bsky.social @naturecomms.bsky.social www.biozentrum.unibas.ch/news/detail/...
If you're using AAVs to develop a gene therapy or to study gene function in skeletal muscle, then this may be of interest to you. In our latest work, we show that AAVs commonly used to deliver transgenes to muscle fibers also target mononuclear cells:
www.cell.com/molecular-th...
www.cell.com/molecular-th...
AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2
Although AAVs are the leading platform for gene delivery to skeletal muscle, the extent
to which they transduce muscle-residing mononuclear cells remains unclear. Here, McGowan
and colleagues address ...
www.cell.com
March 31, 2025 at 8:35 AM
If you're using AAVs to develop a gene therapy or to study gene function in skeletal muscle, then this may be of interest to you. In our latest work, we show that AAVs commonly used to deliver transgenes to muscle fibers also target mononuclear cells:
www.cell.com/molecular-th...
www.cell.com/molecular-th...
Check out our latest publication where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: www.nature.com/articles/s41...
The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.
The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications
Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...
www.nature.com
March 6, 2025 at 1:40 PM
Check out our latest publication where we use single-nuclei RNA-seq to study gene expression at the neuromuscular junction: www.nature.com/articles/s41...
The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.
The paper also characterizes three novel NMJ proteins including the transcription factor ETV4 and the MuSK-binding protein PDZRN4.