@rolandhjerpe.bsky.social
Drug Discovery Leader · TPD · Induced Proximity · Team Builder
www.linkedin.com/in/roland-hjerpe
www.linkedin.com/in/roland-hjerpe
Check out our perspective paper on discovery of monovalent degraders - just out in npg drug discovery!
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Mechanisms that matter: unbiased cellular screening for degraders - npj Drug Discovery
npj Drug Discovery - Mechanisms that matter: unbiased cellular screening for degraders
www.nature.com
October 18, 2025 at 5:45 AM
Check out our perspective paper on discovery of monovalent degraders - just out in npg drug discovery!
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted
Covalent SMARCA2/SMARCA4 degraders from Plexium
patentscope.wipo.int/search/en/de...
patentscope.wipo.int/search/en/de...
WIPO - Search International and National Patent Collections
patentscope.wipo.int
May 15, 2025 at 5:57 PM
Covalent SMARCA2/SMARCA4 degraders from Plexium
patentscope.wipo.int/search/en/de...
patentscope.wipo.int/search/en/de...
Reposted
KAT6 PROTACs from Prelude Therapeutics
patentscope.wipo.int/search/en/de...
patentscope.wipo.int/search/en/de...
WIPO - Search International and National Patent Collections
patentscope.wipo.int
May 15, 2025 at 5:47 PM
KAT6 PROTACs from Prelude Therapeutics
patentscope.wipo.int/search/en/de...
patentscope.wipo.int/search/en/de...
Reposted
Tom McWilliams is looking for a postdoc to work on autophagy, metabolism and the mitochondria in Helsinki, Finland. Great opportunity to do some cutting edge training.
Postdoctoral Researcher in autophagy and metabolic homeostasis
Postdoctoral Researcher in autophagy and metabolic homeostasis
jobs.helsinki.fi
February 24, 2025 at 11:44 AM
Tom McWilliams is looking for a postdoc to work on autophagy, metabolism and the mitochondria in Helsinki, Finland. Great opportunity to do some cutting edge training.
ir.arvinas.com
March 11, 2025 at 12:33 PM
Recent paper out on novel method for measuring target degradation using environment-sensitive chemical probes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Non-invasive in vivo monitoring of PROTAC-mediated protein degradation using an environment-sensitive reporter - Nature Communications
Proteolysis targeting chimeras (PROTACs) enable selective protein degradation but rely on invasive methods like western blotting to assess efficiency. Here, the authors develop an environment-sensitiv...
www.nature.com
February 28, 2025 at 7:28 AM
Recent paper out on novel method for measuring target degradation using environment-sensitive chemical probes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recent paper out with an informative perspective on the future of TPD from Craig Crews and Mackenzie Krone - check it out in Cell Chemical Biology.
Paper: www.cell.com/cell-chemica...
Paper: www.cell.com/cell-chemica...
Next steps for targeted protein degradation
Modalities and applications of targeted protein degradation (TPD) have rapidly expanded
the therapeutic possibilities of proximity induced pharmacology. Here, Krone et al.
spotlight three focal points...
www.cell.com
February 22, 2025 at 10:24 AM
Recent paper out with an informative perspective on the future of TPD from Craig Crews and Mackenzie Krone - check it out in Cell Chemical Biology.
Paper: www.cell.com/cell-chemica...
Paper: www.cell.com/cell-chemica...