Robert Cornwell-Arquitt
@robcornquitt.bsky.social
Biochemistry & Biophysics student and amateur photographer
Reposted by Robert Cornwell-Arquitt
We are excited to share a new publication w/ @JosephYesselman in @NAR_Open. RNA secondary structure prediction and design typically minimize the global free energy. We show that *local* stability compensation is a powerful way of designing RNA structures 1/4
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Analysis of natural structures and chemical mapping data reveals local stability compensation in RNA
Abstract. RNA molecules adopt complex structures that perform essential biological functions across all forms of life, making them promising candidates for
academic.oup.com
July 11, 2025 at 8:52 PM
We are excited to share a new publication w/ @JosephYesselman in @NAR_Open. RNA secondary structure prediction and design typically minimize the global free energy. We show that *local* stability compensation is a powerful way of designing RNA structures 1/4
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Sharing an update on our manuscript centered on local stability compensation (LSC) in RNA, a sort of balancing act between stems and loops.
We added a section about how LSC is distinguished by phylogeny, for example between plant and animal microRNA precursors.
www.biorxiv.org/content/10.1...
We added a section about how LSC is distinguished by phylogeny, for example between plant and animal microRNA precursors.
www.biorxiv.org/content/10.1...
Analysis of natural structures and chemical mapping data reveals local stability compensation in RNA
RNA molecules adopt complex structures that perform essential biological functions across all forms of life, making them promising candidates for therapeutic applications. However, our ability to desi...
www.biorxiv.org
April 12, 2025 at 4:40 PM
Sharing an update on our manuscript centered on local stability compensation (LSC) in RNA, a sort of balancing act between stems and loops.
We added a section about how LSC is distinguished by phylogeny, for example between plant and animal microRNA precursors.
www.biorxiv.org/content/10.1...
We added a section about how LSC is distinguished by phylogeny, for example between plant and animal microRNA precursors.
www.biorxiv.org/content/10.1...
Just a post to "try things out". Here's a #Oregonian #waterfall I captured a while ago at a special time of day.
March 11, 2025 at 4:43 AM
Just a post to "try things out". Here's a #Oregonian #waterfall I captured a while ago at a special time of day.
Reposted by Robert Cornwell-Arquitt
Excited to announce a new collaborative preprint about a structural concept 'local stability compensation'. This states structurally important motifs must be flanked by more stable helices. We observe this effect natural occurring RNAs and experimentally evaluate it. www.biorxiv.org/content/10.1...
December 12, 2024 at 6:19 PM
Excited to announce a new collaborative preprint about a structural concept 'local stability compensation'. This states structurally important motifs must be flanked by more stable helices. We observe this effect natural occurring RNAs and experimentally evaluate it. www.biorxiv.org/content/10.1...