Reuben B. Leveson-Gower
@reubenlg.bsky.social
Assistant Professor in Biocatalysis at TU Delft.
Very happy to see that our latest paper just appeared online in ACS Catalysis. Two directed evolution campaigns of an artificial enzyme from @roelfesgroup.bsky.social found that just 3 mutations could specialise it towards each of its promiscuous activities.
pubs.acs.org/doi/10.1021/acscatal.4c06409
pubs.acs.org/doi/10.1021/acscatal.4c06409
Evolutionary Specialization of a Promiscuous Designer Enzyme
The evolution of a promiscuous enzyme for its various activities often results in catalytically specialized variants. This is an important natural mechanism to ensure the proper functioning of natural...
pubs.acs.org
January 13, 2025 at 2:15 PM
Very happy to see that our latest paper just appeared online in ACS Catalysis. Two directed evolution campaigns of an artificial enzyme from @roelfesgroup.bsky.social found that just 3 mutations could specialise it towards each of its promiscuous activities.
pubs.acs.org/doi/10.1021/acscatal.4c06409
pubs.acs.org/doi/10.1021/acscatal.4c06409