Qingfei (Luke) Zheng
@qzchemsynbiol.bsky.social
Assistant Professor @ Purdue University BMCMP; Chemical/Synthetic Biologist interested in Protein PTMs, Epigenetics, Microbiome, Drug Discovery; Lifelong Guinea Pig Lover (www.zhenglabpurdue.com)
Biocompatible chemistry is wildly applied in the current chemical biology research. The MCMP student, Adam Lovato, did a topic introduction in our group meeting, and now we made it published on ChemBioChem as a review paper! So proud~ 🍾🎉🥳 chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research
The “plug-and-play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes...
chemistry-europe.onlinelibrary.wiley.com
September 26, 2025 at 2:12 PM
Biocompatible chemistry is wildly applied in the current chemical biology research. The MCMP student, Adam Lovato, did a topic introduction in our group meeting, and now we made it published on ChemBioChem as a review paper! So proud~ 🍾🎉🥳 chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
I am happy to share that we recently developed and named a pH-controlled regioselective rapid ene-type reaction as "RRER" for the specific bioconjugation of a novel epigenetic mark, histone serotonylation. It is now online @rscchembio.rsc.org pubs.rsc.org/en/content/a...
Regioselective rapid ene-type reaction (RRER) enables bioconjugation of histone serotonylation
Triazolinedione (TAD) derivatives have been commonly utilized as protection and labeling reagents for indole and phenol moieties via a reversible ene-type reaction. Previous studies showed that the TA...
pubs.rsc.org
July 22, 2025 at 2:16 PM
I am happy to share that we recently developed and named a pH-controlled regioselective rapid ene-type reaction as "RRER" for the specific bioconjugation of a novel epigenetic mark, histone serotonylation. It is now online @rscchembio.rsc.org pubs.rsc.org/en/content/a...
Excited to see our paper out @nature.com In this work, we discovered that histone monoaminylation dynamics are regulated by a single enzyme (TGM2) and can promote neural rhythmicity by inhibiting the binding of WDR5 to H3 N-terminus.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bidirectional histone monoaminylation dynamics regulate neural rhythmicity - Nature
TG2 functions as an eraser and exchanger of H3 monoaminylations, including histaminylation of Gln5 of histone H3.
www.nature.com
January 10, 2025 at 4:06 AM
Excited to see our paper out @nature.com In this work, we discovered that histone monoaminylation dynamics are regulated by a single enzyme (TGM2) and can promote neural rhythmicity by inhibiting the binding of WDR5 to H3 N-terminus.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 2, 2024 at 1:39 PM
Although serotonylation was discovered in the 1950s, a full picture of serotonylated proteins in cells is poorly understood. In this work, we applied pH-controlled CRACR (originally developed by @achemsynbio.bsky.social lab) for profiling serotonylation proteome. www.biorxiv.org/content/10.1...
pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
May 15, 2024 at 3:53 AM
Although serotonylation was discovered in the 1950s, a full picture of serotonylated proteins in cells is poorly understood. In this work, we applied pH-controlled CRACR (originally developed by @achemsynbio.bsky.social lab) for profiling serotonylation proteome. www.biorxiv.org/content/10.1...
04/25/2024, Zheng Lab@OSU, good memories and ready for the new journey.
May 7, 2024 at 2:10 AM
04/25/2024, Zheng Lab@OSU, good memories and ready for the new journey.