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In the recent publication in Nucleic Acids Research, we introduce a single-molecule framework that combines multiple distance measurements with directional mechanical unfolding, enabling simultaneous structural and mechanical fingerprinting of nucleic acids.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Single-molecule mechanostructural fingerprinting of nucleic acid conformations
Abstract. Understanding the three-dimensional structure and mechanical response of biomolecules is key to uncovering their molecular mechanisms, particular
doi.org
January 7, 2026 at 7:36 PM
In the recent publication in Nucleic Acids Research, we introduce a single-molecule framework that combines multiple distance measurements with directional mechanical unfolding, enabling simultaneous structural and mechanical fingerprinting of nucleic acids.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted
Single-molecule mechanostructural fingerprinting of nucleic acid conformations pubmed.ncbi.nlm.nih.gov/41495902/ #cryoem
January 7, 2026 at 8:10 AM
Single-molecule mechanostructural fingerprinting of nucleic acid conformations pubmed.ncbi.nlm.nih.gov/41495902/ #cryoem
Reposted
Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at doi.org/10.1101/2025...
May 4, 2025 at 12:02 AM
Excited to share our new preprint! It's a light-guided approach for precise and programmable molecular patterning, enabling multiplexed single-molecule force spectroscopy—no lithography needed. Read more at doi.org/10.1101/2025...
If you want to unfold the same molecule through multiple directions, DNA nanoswitch caliper is the way to go!
New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025... We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech
May 9, 2025 at 10:09 PM
If you want to unfold the same molecule through multiple directions, DNA nanoswitch caliper is the way to go!