Simon Waddington
@profsimonwad.bsky.social
𝘗𝘳𝘰𝘧𝘦𝘴𝘴𝘰𝘳 𝘰𝘧 𝘎𝘦𝘯𝘦 𝘛𝘩𝘦𝘳𝘢𝘱𝘺, 𝘜𝘊𝘓
𝘎𝘦𝘯𝘦𝘵𝘪𝘤 𝘵𝘩𝘦𝘳𝘢𝘱𝘪𝘦𝘴 𝘧𝘰𝘳 𝘤𝘩𝘪𝘭𝘥𝘩𝘰𝘰𝘥 𝘨𝘦𝘯𝘦𝘵𝘪𝘤 𝘥𝘪𝘴𝘦𝘢𝘴𝘦𝘴
𝘈𝘈𝘝, 𝘭𝘦𝘯𝘵𝘪, 𝘢𝘥𝘦𝘯𝘰, 𝘮𝘙𝘕𝘈
🧬🚲
𝘎𝘦𝘯𝘦𝘵𝘪𝘤 𝘵𝘩𝘦𝘳𝘢𝘱𝘪𝘦𝘴 𝘧𝘰𝘳 𝘤𝘩𝘪𝘭𝘥𝘩𝘰𝘰𝘥 𝘨𝘦𝘯𝘦𝘵𝘪𝘤 𝘥𝘪𝘴𝘦𝘢𝘴𝘦𝘴
𝘈𝘈𝘝, 𝘭𝘦𝘯𝘵𝘪, 𝘢𝘥𝘦𝘯𝘰, 𝘮𝘙𝘕𝘈
🧬🚲
I was in Jerusalem on 1st September 2024. There were protests every week against Netanyahu's attempt to muzzle the legal system and we in the UK, were being warned it might be a travel danger. These are two things I saw, that I found interesting at the time @odedrechavi.bsky.social
October 8, 2025 at 10:47 PM
I was in Jerusalem on 1st September 2024. There were protests every week against Netanyahu's attempt to muzzle the legal system and we in the UK, were being warned it might be a travel danger. These are two things I saw, that I found interesting at the time @odedrechavi.bsky.social
Sorry all, been a bit away from social media - but very happy to show our latest, slightly massive review on neuro gene therapy. Some quite amazing co-authors who dwarf me in their amazingness. Here, as a pre-proof. Still some (quite a bit) of finessing pharmrev.aspetjournals.org/article/S003... 🧪
Genetic therapies for neurological diseases
Often, gene therapy reviews concentrate upon specific therapeutic modalities – particularly
either viral vector-mediated or a non-viral approach. Here, we draw together a comprehensive
array of knowle...
pharmrev.aspetjournals.org
October 3, 2025 at 9:30 PM
Sorry all, been a bit away from social media - but very happy to show our latest, slightly massive review on neuro gene therapy. Some quite amazing co-authors who dwarf me in their amazingness. Here, as a pre-proof. Still some (quite a bit) of finessing pharmrev.aspetjournals.org/article/S003... 🧪
I saw this about baby spiders eating their mother www.theguardian.com/tv-and-radio.... It validated something I saw as a child in the north of England. I was always poking arthropods; poked this spider and the body dissolved into fleeing tiny spiders. Mum never budged again. I thought I imagined it.
Mother-eating spiders ‘will chill parents to the bone’ in new David Attenborough series
African social spiders’ sinister game of ‘grandmother’s footsteps’ could be breakout moment in BBC’s Parenthood
www.theguardian.com
July 28, 2025 at 8:00 PM
I saw this about baby spiders eating their mother www.theguardian.com/tv-and-radio.... It validated something I saw as a child in the north of England. I was always poking arthropods; poked this spider and the body dissolved into fleeing tiny spiders. Mum never budged again. I thought I imagined it.
I cycled this a couple of weeks ago. 200 miles across the UK in one day. Thank you very much for your lovely sponsorship. It was massively inspirational to me to make it before sunset 🙏🏻
July 1, 2025 at 10:21 PM
I cycled this a couple of weeks ago. 200 miles across the UK in one day. Thank you very much for your lovely sponsorship. It was massively inspirational to me to make it before sunset 🙏🏻
Sorry I haven't posted much science/history/gene therapy recently - will get back on this soon. Am doing some preparation for a big cycle ride next month. And did this practice ride a week ago (ride initially mapped by Chris Ward road.cc/content/blog...). Saw so many nice places.
May 29, 2025 at 12:05 PM
Sorry I haven't posted much science/history/gene therapy recently - will get back on this soon. Am doing some preparation for a big cycle ride next month. And did this practice ride a week ago (ride initially mapped by Chris Ward road.cc/content/blog...). Saw so many nice places.
I had the pleasure of being at the @asgct.bsky.social in New Orleans last week - fantastic conference, as always, and a welcoming city. I won't post anything about the conference, just three photos I took of a monument facing the Mississippi River. The "Monument to the Immigrant":
May 21, 2025 at 3:25 PM
I had the pleasure of being at the @asgct.bsky.social in New Orleans last week - fantastic conference, as always, and a welcoming city. I won't post anything about the conference, just three photos I took of a monument facing the Mississippi River. The "Monument to the Immigrant":
Well done to Juan Diaz, Sonam Gurung for their awards @asgct.bsky.social 🧬 🥳🍾
May 15, 2025 at 5:56 PM
Well done to Juan Diaz, Sonam Gurung for their awards @asgct.bsky.social 🧬 🥳🍾
While on a cycle yesterday I parked up and took this photo. Bluebells and fern. Calming
May 3, 2025 at 9:12 PM
While on a cycle yesterday I parked up and took this photo. Bluebells and fern. Calming
As a kid I always thought dandelion clocks were beautiful. They still are.
April 25, 2025 at 5:35 PM
As a kid I always thought dandelion clocks were beautiful. They still are.
A new paper hitting the press: Gene therapy for AIPL-1 retinal dystrophy. Almost all kids with this can only perceive light, at best. Getting early will help with vision also neurodevelopment and psychosocial aspects. 🧬 ⭐ 👁
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study
Our findings indicate that young children with AIPL1-related retinal dystrophy benefited
substantially from subretinal administration of rAAV8.hRKp.AIPL1, with improved visual
acuity and functional vi...
www.thelancet.com
April 14, 2025 at 7:06 AM
A new paper hitting the press: Gene therapy for AIPL-1 retinal dystrophy. Almost all kids with this can only perceive light, at best. Getting early will help with vision also neurodevelopment and psychosocial aspects. 🧬 ⭐ 👁
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Fascinating and comprehensive review just out, exploring the concept of fetal gene therapy for spinal muscular atrophy academic.oup.com/brain/advanc...
In utero therapy for spinal muscular atrophy: closer to clinical translation
In type 1 spinal muscular atrophy, pathological changes begin during prenatal development, which means that a complete cure is unlikely even with early pos
academic.oup.com
April 10, 2025 at 4:25 PM
Fascinating and comprehensive review just out, exploring the concept of fetal gene therapy for spinal muscular atrophy academic.oup.com/brain/advanc...
Brilliant conference and well done to all the @ucltro.bsky.social who did a magnificent job!
🧬The first @ucl.ac.uk Advanced Therapies Symposium is now underway, #UCL2025AdvTx, bringing together UCL scientists and external partners. @profsimonwad.bsky.social kicks off the event and in the photo we have Prof. Stephanie Schorge for her talk. UCL’s #ATMP Pipelines
bit.ly/42dlq1F
bit.ly/42dlq1F
April 10, 2025 at 4:24 PM
Brilliant conference and well done to all the @ucltro.bsky.social who did a magnificent job!
Reposted by Simon Waddington
🧬The first @ucl.ac.uk Advanced Therapies Symposium is now underway, #UCL2025AdvTx, bringing together UCL scientists and external partners. @profsimonwad.bsky.social kicks off the event and in the photo we have Prof. Stephanie Schorge for her talk. UCL’s #ATMP Pipelines
bit.ly/42dlq1F
bit.ly/42dlq1F
April 9, 2025 at 8:54 AM
🧬The first @ucl.ac.uk Advanced Therapies Symposium is now underway, #UCL2025AdvTx, bringing together UCL scientists and external partners. @profsimonwad.bsky.social kicks off the event and in the photo we have Prof. Stephanie Schorge for her talk. UCL’s #ATMP Pipelines
bit.ly/42dlq1F
bit.ly/42dlq1F
Reposted by Simon Waddington
Just been laughing my head off at this alternative phonetic alphabet (Alpha, Bravo, Charlie etc.).
You can play around with it here: web.cs.dal.ca/~jamie/Words...
You can play around with it here: web.cs.dal.ca/~jamie/Words...
March 26, 2025 at 4:55 PM
Just been laughing my head off at this alternative phonetic alphabet (Alpha, Bravo, Charlie etc.).
You can play around with it here: web.cs.dal.ca/~jamie/Words...
You can play around with it here: web.cs.dal.ca/~jamie/Words...
@florianmerkle.bsky.social has BSGCT got a Bluesky account?
March 26, 2025 at 3:15 PM
@florianmerkle.bsky.social has BSGCT got a Bluesky account?
February 8, 2025 at 9:53 AM
Reposted by Simon Waddington
'What comes next? As far as I know, there are no examples of modern nations turning their backs on medical science. But there’s every reason to expect the consequences to be ghastly.'
@pkrugman.bsky.social
paulkrugman.substack.com/p/rfk-jr-and...
@pkrugman.bsky.social
paulkrugman.substack.com/p/rfk-jr-and...
RFK Jr. and the MAGA Death Trip
The war on science is turning deadly
paulkrugman.substack.com
February 7, 2025 at 9:57 AM
'What comes next? As far as I know, there are no examples of modern nations turning their backs on medical science. But there’s every reason to expect the consequences to be ghastly.'
@pkrugman.bsky.social
paulkrugman.substack.com/p/rfk-jr-and...
@pkrugman.bsky.social
paulkrugman.substack.com/p/rfk-jr-and...
Did we listen? No, we didn't @richardsever.bsky.social @helencooksley.bsky.social
February 7, 2025 at 9:19 PM
Did we listen? No, we didn't @richardsever.bsky.social @helencooksley.bsky.social
New paper out now - ascending infection during pregnancy results in neonatal morbidity - brain, lung, gut pathology - unique model of human newborn morbidity following infection-associated preterm birth @ucl-ifwh.bsky.social @dmacintyre.bsky.social ajp.amjpathol.org/article/S000...
Ascending vaginal infection in mice induces preterm birth and neonatal morbidity
Preterm birth (PTB; delivery <37 weeks), the main cause of neonatal death worldwide,
can lead to adverse neurodevelopmental outcomes, as well as lung and gut pathology.
PTB can be associated with asce...
ajp.amjpathol.org
February 3, 2025 at 1:17 PM
New paper out now - ascending infection during pregnancy results in neonatal morbidity - brain, lung, gut pathology - unique model of human newborn morbidity following infection-associated preterm birth @ucl-ifwh.bsky.social @dmacintyre.bsky.social ajp.amjpathol.org/article/S000...
Goodbye Mum. Rest in peace 🧡
Anne Maureen Waddington. 28.03.1931-10.01.2025
Anne Maureen Waddington. 28.03.1931-10.01.2025
January 29, 2025 at 11:05 PM
Goodbye Mum. Rest in peace 🧡
Anne Maureen Waddington. 28.03.1931-10.01.2025
Anne Maureen Waddington. 28.03.1931-10.01.2025
Reposted by Simon Waddington
✨️Postdocs & PIs✨️
I'm crafting an article with personal tips for PhD students on choosing and surviving postdocs.
What advice do you wish you had or would give your younger self? What crucial insight do you wish you knew earlier?
Share your wisdom! 💡
@academic-chatter.bsky.social
I'm crafting an article with personal tips for PhD students on choosing and surviving postdocs.
What advice do you wish you had or would give your younger self? What crucial insight do you wish you knew earlier?
Share your wisdom! 💡
@academic-chatter.bsky.social
a colorful question mark with a blue circle in the middle
Alt: a colorful question mark with a blue circle in the middle
media.tenor.com
January 22, 2025 at 6:19 PM
Now live - our review of neurodegeneration in lysosomal storage disease - comparing and contrasting disease mechanisms; emerging evidence of unifying convergence @jimd-editors.bsky.social @ucl-ifwh.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Unifying biology of neurodegeneration in lysosomal storage diseases
There are currently at least 70 characterised lysosomal storage diseases (LSD) resultant from inherited single-gene defects. Of these, at least 30 present with central nervous system (CNS) neurodegen...
onlinelibrary.wiley.com
January 18, 2025 at 12:33 PM
Now live - our review of neurodegeneration in lysosomal storage disease - comparing and contrasting disease mechanisms; emerging evidence of unifying convergence @jimd-editors.bsky.social @ucl-ifwh.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Simon Waddington
This is our company, we have partnered and embedded ourselves into the world famous National Hospital for Neurology at Queen's Square. This is the quickest way to get our test for Parkinson's disease into the NHS. This is massive.
www.uclh.nhs.uk/news/nhs-pat...
www.uclh.nhs.uk/news/nhs-pat...
NHS patients to benefit from state-of-the-art diagnostic tests for Parkinson’s & Mitochondrial diseases, resulting from a UK-first partnership : University College London Hospitals NHS Foundation Trus...
Next generation testing, artificial intelligence, advanced mass spectrometry and machine learning is about to be used for diagnostics in the U.K. thanks to a new partnership between UCLH and Guilford ...
www.uclh.nhs.uk
January 10, 2025 at 10:26 PM
This is our company, we have partnered and embedded ourselves into the world famous National Hospital for Neurology at Queen's Square. This is the quickest way to get our test for Parkinson's disease into the NHS. This is massive.
www.uclh.nhs.uk/news/nhs-pat...
www.uclh.nhs.uk/news/nhs-pat...
1953 Rosalind Franklin 🧪. She elucidated the structure of tobacco mosaic virus, showing that the RNA genome was embedded in the protein capsid, performed the foundation work to determine the structure of poliomyelitis virus, and provided the data to determine that DNA exists as a double-helix
January 8, 2025 at 3:56 PM
1953 Rosalind Franklin 🧪. She elucidated the structure of tobacco mosaic virus, showing that the RNA genome was embedded in the protein capsid, performed the foundation work to determine the structure of poliomyelitis virus, and provided the data to determine that DNA exists as a double-helix
Reposted by Simon Waddington
Almost 90 people now listed in this starter pack for Reproductive Sciences
#ReproSky 🧪
go.bsky.app/R19Temj
#ReproSky 🧪
go.bsky.app/R19Temj
January 4, 2025 at 3:29 AM
Almost 90 people now listed in this starter pack for Reproductive Sciences
#ReproSky 🧪
go.bsky.app/R19Temj
#ReproSky 🧪
go.bsky.app/R19Temj