Jochen Prehn
@profjochen.bsky.social
Professor of Physiology. Researcher. Like to see where cells are and how they are. Prefer cancer cells dead, and neurones alive and happy. Not afraid of AI.
Excellent collaboration with @annagolebiewska.bsky.social delivering humanised glioblastoma patient-derived xenograft models to test novel immunotherapy strategies for brain cancer. www.biorxiv.org/content/10.1...
Humanized glioblastoma patient-derived orthotopic xenografts recreate a locally immunosuppressed human immune ecosystem amenable to immunotherapeutic modulation
Immune-based strategies have so far failed to demonstrate clinical benefit in glioblastoma (GBM), largely due to the profound immunosuppressive tumor microenvironment (TME). To achieve more predictive...
www.biorxiv.org
November 24, 2025 at 11:37 AM
Excellent collaboration with @annagolebiewska.bsky.social delivering humanised glioblastoma patient-derived xenograft models to test novel immunotherapy strategies for brain cancer. www.biorxiv.org/content/10.1...
Big thanks also to Boris Rogelj who acted as extern and gave an excellent talk on RNAs that bind proteins (or was it proteins that bind RNAs 🤔) in ALS and FTD. @physiologyrcsi.bsky.social
July 24, 2025 at 12:07 PM
Big thanks also to Boris Rogelj who acted as extern and gave an excellent talk on RNAs that bind proteins (or was it proteins that bind RNAs 🤔) in ALS and FTD. @physiologyrcsi.bsky.social
Congratulations to Qilian who passed her PhD viva investigating effects of tiRNAs on FUS phase transition in ALS @physiologyrcsi.bsky.social
July 24, 2025 at 12:02 PM
Congratulations to Qilian who passed her PhD viva investigating effects of tiRNAs on FUS phase transition in ALS @physiologyrcsi.bsky.social
Delighted for Prof Annette Byrne @physiologyrcsi.bsky.social to be elected as a member of the Royal Irish Academy yesterday for her achievements on cancer research.
May 28, 2025 at 11:25 AM
Delighted for Prof Annette Byrne @physiologyrcsi.bsky.social to be elected as a member of the Royal Irish Academy yesterday for her achievements on cancer research.
Congrats to Batuhan Khisakol and all @physiologyrcsi.bsky.social PhD students who were conferred today!
May 27, 2025 at 7:24 PM
Congrats to Batuhan Khisakol and all @physiologyrcsi.bsky.social PhD students who were conferred today!
Reposted by Jochen Prehn
speaker list is now expanded! sessions on cancer, evolution, metabolic disease, multi-omics, AI. speakers include @epetsalaki.bsky.social @ciriellolab.bsky.social @juliosaezrod.bsky.social @molsysbio.bsky.social @inesthiele.bsky.social @profjochen.bsky.social @renskevroomans.bsky.social +tons more
We will be hosting the International Conference on Systems Biology (ICSB) in Dublin this year – 5-9th October icsb2025.com/registration/ #ICSB2025
April 30, 2025 at 1:16 PM
speaker list is now expanded! sessions on cancer, evolution, metabolic disease, multi-omics, AI. speakers include @epetsalaki.bsky.social @ciriellolab.bsky.social @juliosaezrod.bsky.social @molsysbio.bsky.social @inesthiele.bsky.social @profjochen.bsky.social @renskevroomans.bsky.social +tons more
Reposted by Jochen Prehn
@heikoimaging.bsky.social presenting work done on Fuso bacterium in CRC together with Barry McGuire and @profjochen.bsky.social et al working @physiologyrcsi.bsky.social in @rcsi.bsky.social
April 30, 2025 at 5:47 PM
@heikoimaging.bsky.social presenting work done on Fuso bacterium in CRC together with Barry McGuire and @profjochen.bsky.social et al working @physiologyrcsi.bsky.social in @rcsi.bsky.social
Reposted by Jochen Prehn
🚨JOB OPPORTUNITY🚨
Post-doc with molecular biology/experimental background to perform spatial and single-cell experiments with @profjochen.bsky.social 's group
🔗 in comment
Post-doc with molecular biology/experimental background to perform spatial and single-cell experiments with @profjochen.bsky.social 's group
🔗 in comment
February 13, 2025 at 11:03 AM
🚨JOB OPPORTUNITY🚨
Post-doc with molecular biology/experimental background to perform spatial and single-cell experiments with @profjochen.bsky.social 's group
🔗 in comment
Post-doc with molecular biology/experimental background to perform spatial and single-cell experiments with @profjochen.bsky.social 's group
🔗 in comment
When chemotherapy may do harm - super plexing of cell death proteins shows that ‘persister’ cells do not benefit from 5-FU based adjuvant chemotherapy in colon cancer bmjoncology.bmj.com/content/3/1/...
Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy
Objective Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multi...
bmjoncology.bmj.com
February 3, 2025 at 11:13 PM
When chemotherapy may do harm - super plexing of cell death proteins shows that ‘persister’ cells do not benefit from 5-FU based adjuvant chemotherapy in colon cancer bmjoncology.bmj.com/content/3/1/...
Delighted to chair the ‘Clinical Decision Support Tools’ session at #ICSB2025 in Dublin, Oct 5-9 youtu.be/i8ekr_KmwvA
@rcsi.bsky.social @physiologyrcsi.bsky.social @rcsi-research.bsky.social
@rcsi.bsky.social @physiologyrcsi.bsky.social @rcsi-research.bsky.social
24th Annual International Conference on Systems Biology (ICSB 2025)
YouTube video by Systems Biology Ireland Official
youtu.be
January 29, 2025 at 8:44 PM
Delighted to chair the ‘Clinical Decision Support Tools’ session at #ICSB2025 in Dublin, Oct 5-9 youtu.be/i8ekr_KmwvA
@rcsi.bsky.social @physiologyrcsi.bsky.social @rcsi-research.bsky.social
@rcsi.bsky.social @physiologyrcsi.bsky.social @rcsi-research.bsky.social
What are the biological functions of stress-induced tiRNAs (tRNA fragments) - we took an unbiased approach exploring an #ALS associated tiRNA www.sciencedirect.com/science/arti... @physiologyrcsi.bsky.social @rcsi-research.bsky.social @mndresearch.bsky.social #ncRNA #MND
January 6, 2025 at 4:02 PM
What are the biological functions of stress-induced tiRNAs (tRNA fragments) - we took an unbiased approach exploring an #ALS associated tiRNA www.sciencedirect.com/science/arti... @physiologyrcsi.bsky.social @rcsi-research.bsky.social @mndresearch.bsky.social #ncRNA #MND
Focus on 💪 in ALS: We found a new role for Angiogenin in muscle regeneration with diagnostic implications. onlinelibrary.wiley.com/doi/10.1111/... @mndresearch.bsky.social @rcsi-research.bsky.social @physiologyrcsi.bsky.social @neuroscienceirl.bsky.social #ALSResearch #MNDResearch
January 2, 2025 at 1:15 PM
Focus on 💪 in ALS: We found a new role for Angiogenin in muscle regeneration with diagnostic implications. onlinelibrary.wiley.com/doi/10.1111/... @mndresearch.bsky.social @rcsi-research.bsky.social @physiologyrcsi.bsky.social @neuroscienceirl.bsky.social #ALSResearch #MNDResearch
Dr Batu! - delighted that @researchireland.bsky.social @genomicscrt PhD student Batuhan Kisakol has passed his viva today- with no corrections! Thanks to examiners @sudiptodas_rcsi and @oncode.bsky.social ‘s JP Medema @rcsi-research.bsky.social @physiologyrcsi.bsky.social 🎉👏🏻🍾🎓
December 20, 2024 at 1:30 AM
Dr Batu! - delighted that @researchireland.bsky.social @genomicscrt PhD student Batuhan Kisakol has passed his viva today- with no corrections! Thanks to examiners @sudiptodas_rcsi and @oncode.bsky.social ‘s JP Medema @rcsi-research.bsky.social @physiologyrcsi.bsky.social 🎉👏🏻🍾🎓
Fully funded MSC PhD positions in AI and Parkinson’s Disease now available, including two positions at @rcsi.bsky.social Apply at .aipd-dn.eu/en/vacancies... @rcsi-research.bsky.social
November 25, 2024 at 11:03 AM
Fully funded MSC PhD positions in AI and Parkinson’s Disease now available, including two positions at @rcsi.bsky.social Apply at .aipd-dn.eu/en/vacancies... @rcsi-research.bsky.social
Congrats to my former MD student Bill Duggan for the @rcsi.bsky.social Postgraduate School 2024 Clinical Research Award for his @gutmicrobes.bsky.social paper on spatial effects of bacterial infection on the transcriptome in colorectal cancer @rcsi-research.bsky.social @physiologyrcsi.bsky.social
November 23, 2024 at 6:26 AM
Congrats to my former MD student Bill Duggan for the @rcsi.bsky.social Postgraduate School 2024 Clinical Research Award for his @gutmicrobes.bsky.social paper on spatial effects of bacterial infection on the transcriptome in colorectal cancer @rcsi-research.bsky.social @physiologyrcsi.bsky.social
Our new manuscript is out showing distinct fingerprints of tRNA fragments during neurodegeneration, led by our SFI CRT GDS PhD student Sharada Baindoor. doi.org/10.1242/dmm....
November 18, 2024 at 11:20 AM
Our new manuscript is out showing distinct fingerprints of tRNA fragments during neurodegeneration, led by our SFI CRT GDS PhD student Sharada Baindoor. doi.org/10.1242/dmm....