Professor Adam P. Sharples
@profadamsharples.bsky.social
Professor of Molecular Physiology | Our Group 1st Demonstrated that Human Skeletal Muscle Possesses an Epigenetic Memory of Exercise -Our DNA Remembers Exercise! | ExProRugby
Nice feature in @theatlantic.com by @bonnietsui.bsky.social
Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth- it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses.
www.theatlantic.com/health/2026/...
Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth- it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses.
www.theatlantic.com/health/2026/...
A Different Type of ‘Muscle Memory’
Repeated exercise, or wasting, can change the way key genes work.
www.theatlantic.com
January 15, 2026 at 9:39 AM
Nice feature in @theatlantic.com by @bonnietsui.bsky.social
Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth- it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses.
www.theatlantic.com/health/2026/...
Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth- it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses.
www.theatlantic.com/health/2026/...
Nice new data from @DrMikeRoberts team!
Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training
doi.org/10.1101/2025...
Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training
doi.org/10.1101/2025...
Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training
Ribosome biogenesis is a key driver of resistance training (RT)-induced skeletal muscle hypertrophy in humans. However, high resolution insight into RT-induced compositional alterations in ribosomes r...
doi.org
November 6, 2025 at 5:14 PM
Nice new data from @DrMikeRoberts team!
Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training
doi.org/10.1101/2025...
Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training
doi.org/10.1101/2025...
New @biorxivpreprint.bsky.social
Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control
doi.org/10.1101/2025...
Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control
doi.org/10.1101/2025...
Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control
Mitophagy is an essential component of the mitochondrial quality control program, maintaining mitochondrial homeostasis in metabolic tissues such as skeletal muscle. With age, it is thought that mitoc...
doi.org
November 6, 2025 at 5:09 PM
New @biorxivpreprint.bsky.social
Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control
doi.org/10.1101/2025...
Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control
doi.org/10.1101/2025...
First post on Blue Sky
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
October 31, 2025 at 4:34 PM
First post on Blue Sky
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
New pre-print!
Does muscle remember disuse muscle wasting?
Our new study shows skeletal muscle retains a molecular memory of disuse!
Young muscle shows transcriptional resilience to repeated atrophy.
Aged muscle shows exaggerated susceptibility.
doi.org/10.1101/2025...
Reposted by Professor Adam P. Sharples
A heavy lift from a literal strongman, PhD candidate PJ Koopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 www.biorxiv.org/content/10.1...
www.biorxiv.org
October 30, 2025 at 11:16 AM
A heavy lift from a literal strongman, PhD candidate PJ Koopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 www.biorxiv.org/content/10.1...
Reposted by Professor Adam P. Sharples
Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪
Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle https://www.biorxiv.org/content/10.1101/2025.10.16.681134v1
October 18, 2025 at 1:15 AM
Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪