Rob Moran
@prob91.bsky.social
co-founder of ContamClub • plasmid fan • purveyor of artisanal bioinformatics
Our new paper in MGen traces the evolution of a plasmid lineage associated with MDR in Enterococcus faecium, primarily driven by IS1216
For anyone interested in plasmid structures and the smaller MGEs that shape them 🧵👇 [1/14]
@microbiologysociety.org
www.microbiologyresearch.org/content/jour...
For anyone interested in plasmid structures and the smaller MGEs that shape them 🧵👇 [1/14]
@microbiologysociety.org
www.microbiologyresearch.org/content/jour...
IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium, but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of tw...
www.microbiologyresearch.org
December 18, 2025 at 7:46 AM
Our new paper in MGen traces the evolution of a plasmid lineage associated with MDR in Enterococcus faecium, primarily driven by IS1216
For anyone interested in plasmid structures and the smaller MGEs that shape them 🧵👇 [1/14]
@microbiologysociety.org
www.microbiologyresearch.org/content/jour...
For anyone interested in plasmid structures and the smaller MGEs that shape them 🧵👇 [1/14]
@microbiologysociety.org
www.microbiologyresearch.org/content/jour...
Reposted by Rob Moran
The first preprint from @izziepotterill.bsky.social PhD. A clone within ST131 clade C with a totally unique capsule region.
Genomic rearrangement of the capsule operon in a phylogenetically distinct cluster of the multi-drug resistant Escherichia coli lineage ST131 https://www.biorxiv.org/content/10.64898/2025.12.15.689991v1
December 16, 2025 at 7:52 PM
The first preprint from @izziepotterill.bsky.social PhD. A clone within ST131 clade C with a totally unique capsule region.
Reposted by Rob Moran
Maybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases?
August 20, 2025 at 10:27 AM
Maybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases?
Reposted by Rob Moran
Happy Noodlococcus day to all those who celebrate! 🍜🧫🦠
We’re in 3 different continents now but all celebrating the 6th anniversary of the discovery of our noodle-y friend by eating some delicious noodles @prob91.bsky.social @biostan.bsky.social @gemccallum.bsky.social
We’re in 3 different continents now but all celebrating the 6th anniversary of the discovery of our noodle-y friend by eating some delicious noodles @prob91.bsky.social @biostan.bsky.social @gemccallum.bsky.social
August 9, 2025 at 2:44 PM
Happy Noodlococcus day to all those who celebrate! 🍜🧫🦠
We’re in 3 different continents now but all celebrating the 6th anniversary of the discovery of our noodle-y friend by eating some delicious noodles @prob91.bsky.social @biostan.bsky.social @gemccallum.bsky.social
We’re in 3 different continents now but all celebrating the 6th anniversary of the discovery of our noodle-y friend by eating some delicious noodles @prob91.bsky.social @biostan.bsky.social @gemccallum.bsky.social
Reposted by Rob Moran
🚨New pre-print 🚨
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
Genome co-adaptation and the evolution of methicillin resistant Staphylococcus aureus (MRSA)
Background: Antimicrobial resistance (AMR) in bacterial pathogens is a major threat to global health, rendering standard treatments ineffective and increasing the risk of severe infection or death. Re...
www.biorxiv.org
July 23, 2025 at 10:50 AM
🚨New pre-print 🚨
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
We introduce our new tool GOLD-GWAS and demonstrate its use by digging into the evolution of MRSA facilitated by SCCmec
This work was led by talented PhD student @seungwonko.bsky.social who did most of the computational heavylifting 1/n
www.biorxiv.org/content/10.1...
Reposted by Rob Moran
New manuscript from the group
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium
pRUM-like plasmids are commonly found in multidrug-resistant Enterococcus faecium , but the evolution of these plasmids has not been characterised in detail. When we analysed the genome sequences of t...
www.biorxiv.org
July 17, 2025 at 8:39 AM
New manuscript from the group
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1
'IS1216 drives the evolution of pRUM-like multidrug resistance plasmids in Enterococcus faecium'
www.biorxiv.org/content/10.1...
/1