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pccantidoping.bsky.social
Partnership for Clean Competition
@pccantidoping.bsky.social
We support analytical/social scientists doing anti-doping research via grants, postdoctoral fellowships, tech transfer, & working groups. PIs worldwide may apply.
Authors developed & validated a protocol to improve erythropoietin (EPO) gene doping detection using dried blod spots (DBS). Polymer-based DBS cards were most effective, & the EPO transgene was detected with just 100 copies/20-μL DBS via the @tassoinc.bsky.social M-20 device. 🧪
tinyurl.com/mwephas4
December 30, 2025 at 6:51 PM
This study examined the impact of oral and transdermal testosterone administration on phase II metabolites in both men and women. Results showed variability was higher in women due to lower steroid concentrations and menstrual cycle-related fluctuations. 🚫💊 🧪

www.sciencedirect.com/science/arti...
Evaluation of endogenous steroid sulfates and glucuronides in urine after oral and transdermal administration of testosterone. Part II: Female participants
Detecting testosterone (T) doping remains a significant challenge, driving the search for novel biomarkers and advancements in the steroidal Athlete’s…
www.sciencedirect.com
December 29, 2025 at 6:56 PM
This review explores current and potential roles that #metabolomics can play in #antidoping, and how pairing it with machine learning could enhance our ability to detect patterns, classify samples, and detect anomalies.

pmc.ncbi.nlm.nih.gov/articles/PMC...

#machinelearning #ML #AI #science
December 26, 2025 at 7:43 PM
Dr. Daniel Westmattelmann shares his recently published work using simulations to study the impacts of sample retention & re-analysis on doping behavior and doping detection.

Listen to the full episode here:
cleancompetition.org/anti-doping-...

#antidoping #podcast #cleansport #research #science
December 23, 2025 at 3:35 PM
Authors found a new metabolite (M8) of the SARM LGD-4033 that is detectable up to 6 days post-administration. Analyzing M8 & other long-term metabolites may help estimate LGD-4033 intake time & distinguish between standard doping dosing, micro-dosing & inadvertent exposure. 🚫💊 🧪
tinyurl.com/mrdwyxjd
Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake
A novel early excreted minor metabolite of LGD-4033 was detected and coded as M8. Its presence was evaluated as an indicator of recent substance intake versus end-tail findings. Additionally, the ago...
analyticalsciencejournals.onlinelibrary.wiley.com
December 22, 2025 at 6:06 PM
The American College of Sports Medicine provides an update to its position stance on blood doping for the first time since 1996, due to emerging blood doping threats and significant technological advances in anti-doping practices.

lnkd.in/gBN9cxJR
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December 19, 2025 at 7:33 PM
Authors found a metabolite ratio that differed between methyltestosterone (MT) administration routes & could inform interpretation of results. The detection window was much shorter for MT in dried blood spots vs metabolites in urine.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1...
December 19, 2025 at 3:11 PM
What are the benefits of remote sampling in #antidoping ? Dr. Daniel Westmattelmann discusses his transition from a professional cyclist to anti-doping research, as well as the outcomes of his PCC-funded project to implement a remote sampling system.

cleancompetition.org/anti-doping-...
164 - Investigating Remote Sampling, Sample Retention and Re-Analysis, and Athlete Experiences in Anti-Doping - Daniel Westmattelmann, PhD - PCC - Global Anti-Doping Research Grants for Scientists and...
0.75x 1x 1.25x 1.5x 2x 0:0042:53 164 – Investigating Remote Sampling, Sample Retention and Re-Analysis, and Athlete Experiences in Anti-Doping – Daniel Westmattelmann, PhD Apple PodcastsGoogle Podcast...
cleancompetition.org
December 17, 2025 at 4:44 PM
In this PCC-funded project, authors examined the urinary excretion profile of trenbolone and its metabolites after oral, transdermal, and buccal administration. They identified a metabolite that was more abundant after transdermal and buccal administration. 🚫💊 🧪
www.sciencedirect.com/science/arti...
The influence of the route of drug administration on the metabolic profile of trenbolone in doping control urine samples
Advances in analytical techniques have markedly improved the detection of anabolic–androgenic steroids (AAS) in doping controls. This represents a maj…
www.sciencedirect.com
December 15, 2025 at 7:06 PM
Authors developed & validated a high-throughput method to screen for 30 steroid esters and a confirmatory method for 26 targets using dried blood spots. This could be an efficient, sensitive, & automated way to differentiate between endogenous & synthetic steroids. 🚫💊 🧪

pubs.acs.org/doi/10.1021/...
Modified Fully Automated Dried Blood Spot Sample Preparation System and Its Application in Steroid Ester Detection
The detection of anabolic androgenic steroids (AAS) remains a significant challenge in antidoping, particularly in distinguishing endogenous steroids from their synthetic counterparts. Although isotop...
pubs.acs.org
December 12, 2025 at 3:54 PM
How can we make the most of limited resources in #antidoping? Authors developed a framework that assesses the potential performance-enhancing effects of substance categories across 6 physiological demands & maps the effects to the physiological profiles of 160 sport disciplines.
tinyurl.com/muxtah38
Mapping of the Pharmacological Effect of Prohibited Substances and Methods to Athletic Physiological Characteristics
Expected performance benefits for each prohibited substance/method has been presented. Several disciplines are highlighted as an example. The y$$ y $$-axis is ordered by the median benefit score.
analyticalsciencejournals.onlinelibrary.wiley.com
December 10, 2025 at 4:51 PM
What does it take to run a successful WADA-accredited anti-doping lab? Dr. Rosa Ventura Alemany provides a behind-the-scenes look at the excellent work she & colleagues are doing at the Catalonian #Antidoping Laboratory in research & routine testing. 👩‍🔬 🧪

cleancompetition.org/anti-doping-podcast/163
December 9, 2025 at 6:04 PM
Growth hormone-releasing hormone & synthetic analogs are prohibited in sport, but hard to detect w/ traditional urine analyses. Authors developed & validated a new method & workflow that is sensitive, specific & reliable for detecting & confirming the target peptides in urine. 🧪
tinyurl.com/48hxtv38
Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry
Growth hormone-releasing hormone (GHRH) and its synthetic analogs are considered performance-enhancing substances and are therefore prohibited by the …
www.sciencedirect.com
December 4, 2025 at 5:14 PM
Celebrating its 40th anniversary this year, the Catalonian Anti-Doping Laboratory has made a myriad of contributions to #cleansport. Dr. Rosa Ventura Alemany shared the lab's history, current #antidoping research projects, and more in a new podcast episode:
cleancompetition.org/anti-doping-...
163 - 40 Years of Advancing Anti-Doping at the Catalonia Anti-Doping Laboratory - Rosa Ventura Alemany, PhD - PCC - Global Anti-Doping Research Grants for Scientists and Researchers
0.75x 1x 1.25x 1.5x 2x 0:0037:42 163 – 40 Years of Advancing Anti-Doping at the Catalonia Anti-Doping Laboratory – Rosa Ventura Alemany, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a Revi...
cleancompetition.org
December 2, 2025 at 6:31 PM
Authors found CERAs (used in blood doping) are more stable & detectable w/ serum & dried blood spots (DBS) vs urine. Flagged Athlete Biological Passport changes in reticulocyte % also support targeted serum tests & lead to detection.

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
CERA Detection and Stability in Blood Versus Urine
This study presents comparative data on CERA detection in serum and urine samples, highlighting adverse analytical findings (AAFs) in serum that were undetected in corresponding urine samples. This s...
analyticalsciencejournals.onlinelibrary.wiley.com
December 1, 2025 at 5:07 PM
We're pleased to highlight a recent PCC-funded research project, led by Dr. Martin Bidlingmaier, to examine soluble alpha klotho (sαKL) as a potential marker of growth hormone (GH) doping. sαKL is a protein in blood & urine that is impacted in clinical conditions with excess or deficient GH levels.
November 28, 2025 at 7:41 PM
"Brain doping" is gaining attention in sport, & this review identified only 9 studies on brain doping substances shown to ⬆️ sports performance. They also examined active ingredients that promote cognition in supplements to see how they fit w/in #antidoping rules.
pmc.ncbi.nlm.nih.gov/articles/PMC...
November 26, 2025 at 5:36 PM
Dr. John Eiler is using #massspectrometry technology to identify the exact locations of isotopes in atoms in a PCC-funded research project to detect the molecular isotopic structures of substances in #antidoping samples.

Learn more in our latest podcast episode:
cleancompetition.org/anti-doping-...
November 25, 2025 at 5:19 PM
Performance-enhancing drugs compromise the integrity of sport, and they can cause a wide range of negative health effects. This recent review article examines the latest evidence surrounding the negative cardiovascular effects of doping.

www.minervamedica.it/en/journals/...
#antidoping #science
The cardiovascular risk of doping and substance abuse in athletes - The Journal of Sports Medicine and Physical Fitness 2025 October;65(10):1401-12
The cardiovascular risk of doping and substance abuse in athletes
www.minervamedica.it
November 24, 2025 at 7:22 PM
An increasing body of research supports that tDCS impacts endurance, strength, skill acquisition & perceived exertion. This recent editorial discusses how tDCS works, what we know about its ergogenic effects, & how it may fit within the framework of “neurodoping”. 🧪
pubmed.ncbi.nlm.nih.gov/41078301/
November 21, 2025 at 5:04 PM
The synthetic steroidal SARM S42 is prohibited in sport due to potential performance-enhancing effects. To improve detection of S42 misuse, the PCC funded a research project, led by Dr. Mario Thevis, to investigate the metabolism of S42 to inform the development of new #antidoping detection methods.
November 21, 2025 at 4:51 PM
Authors developed a rapid method using a CRISPR/CAS-based assay & double emulsion droplets to detect human erythropoietin gene doping. They validated the approach in spiked serum samples, & their results show excellent sensitivity & specificity. 🚫💊 🧪

advanced.onlinelibrary.wiley.com/doi/10.1002/...
November 19, 2025 at 6:16 PM
How can approaches from geosciences advance #antidoping? Dr. John Eiler discusses his research, a recent PCC-funded project examining use of molecular isotopic structure for doping forensics, promising new results, and the potential impacts of this work. 🚫💊 🧪

cleancompetition.org/anti-doping-...
162 - Leveraging Molecular Isotopic Structure in Anti-Doping Analyses - John Eiler, PhD - PCC - Global Anti-Doping Research Grants for Scientists and Researchers
0.75x 1x 1.25x 1.5x 2x 0:0056:13 162 – Leveraging Molecular Isotopic Structure in Anti-Doping Analyses – John Eiler, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a ReviewListen in a New Wi...
cleancompetition.org
November 18, 2025 at 4:25 PM
SARMs are increasingly detected in #antidoping analyses, & in-depth drug characterization can help understand health risks & improve detection. Authors examined the absorption, distribution, metabolism, & excretion of the novel non-steroidal SARM ACP-105. 🧪

link.springer.com/article/10.1...
First multifaceted ADME profile of ACP-105 (CAS: 1048998-11-3): a novel non-steroidal selective androgen receptor modulator used as doping in sports—integrative in silico toxicological studies for cli...
ACP-105 (CAS: 1048998-11-3) is a novel non-steroidal selective androgen receptor modulator (SARM), increasingly detected in anti-doping analyses, yet lacking a comprehensive ADME profile. This study p...
link.springer.com
November 17, 2025 at 5:18 PM
Roxadustat has erythropoietic, cardioprotective, and metabolic regulatory effects and is prohibited in sport. This review details what we know about its mechanisms of action, legitimate clinical uses, how it can be detected in #antidoping analyses, and more. 🧪

pmc.ncbi.nlm.nih.gov/articles/PMC...
November 14, 2025 at 4:33 PM