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pccantidoping.bsky.social
Partnership for Clean Competition
@pccantidoping.bsky.social
200 followers 51 following 640 posts
We support analytical/social scientists doing anti-doping research via grants, postdoctoral fellowships, tech transfer, & working groups. PIs worldwide may apply.
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pccantidoping.bsky.social
Authors developed & validated a protocol to improve erythropoietin (EPO) gene doping detection using dried blod spots (DBS). Polymer-based DBS cards were most effective, & the EPO transgene was detected with just 100 copies/20-μL DBS via the @tassoinc.bsky.social M-20 device. 🧪
tinyurl.com/mwephas4
The image provides details about the paper linked in the post. It was published in the journal Drug Testing and Analysis, and the title of the article is, "Improvement of EPO Transgene Detection From Polymeric Dried Blood Spots for Antidoping Application".
December 30, 2025 at 6:51 PM
pccantidoping.bsky.social
This study examined the impact of oral and transdermal testosterone administration on phase II metabolites in both men and women. Results showed variability was higher in women due to lower steroid concentrations and menstrual cycle-related fluctuations. 🚫💊 🧪

www.sciencedirect.com/science/arti...
Evaluation of endogenous steroid sulfates and glucuronides in urine after oral and transdermal administration of testosterone. Part II: Female participants
Detecting testosterone (T) doping remains a significant challenge, driving the search for novel biomarkers and advancements in the steroidal Athlete’s…
www.sciencedirect.com
December 29, 2025 at 6:56 PM
pccantidoping.bsky.social
This review explores current and potential roles that #metabolomics can play in #antidoping, and how pairing it with machine learning could enhance our ability to detect patterns, classify samples, and detect anomalies.

pmc.ncbi.nlm.nih.gov/articles/PMC...

#machinelearning #ML #AI #science
This image shows details about the article linked in the post. It was published in the journal Metabolites, and the title of the article is, "Integrating Advanced Metabolomics and Machine Learning for Anti-Doping in Human Athletes".
December 26, 2025 at 7:43 PM
pccantidoping.bsky.social
Dr. Daniel Westmattelmann shares his recently published work using simulations to study the impacts of sample retention & re-analysis on doping behavior and doping detection.

Listen to the full episode here:
cleancompetition.org/anti-doping-...

#antidoping #podcast #cleansport #research #science
This image shows a headshot photo of Daniel in the lower right corner and a quote from the podcast episode: "Because we can't run controlled experiments on the whole anti-doping system, because we cannot really measure the real doping prevalence, we use a so-called social simulation and thereby we were able to create a computer simulation, like a virtual population of athletes. There we can measure what effect difference anti-doping measures have on the population level. There we can really transparently measure what is the impact on the real prevalence rate but also the effect on the detection rate."
December 23, 2025 at 3:35 PM
pccantidoping.bsky.social
Authors found a new metabolite (M8) of the SARM LGD-4033 that is detectable up to 6 days post-administration. Analyzing M8 & other long-term metabolites may help estimate LGD-4033 intake time & distinguish between standard doping dosing, micro-dosing & inadvertent exposure. 🚫💊 🧪
tinyurl.com/mrdwyxjd
Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake
A novel early excreted minor metabolite of LGD-4033 was detected and coded as M8. Its presence was evaluated as an indicator of recent substance intake versus end-tail findings. Additionally, the ago...
analyticalsciencejournals.onlinelibrary.wiley.com
December 22, 2025 at 6:06 PM
pccantidoping.bsky.social
The American College of Sports Medicine provides an update to its position stance on blood doping for the first time since 1996, due to emerging blood doping threats and significant technological advances in anti-doping practices.

lnkd.in/gBN9cxJR
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December 19, 2025 at 7:33 PM
pccantidoping.bsky.social
Authors found a metabolite ratio that differed between methyltestosterone (MT) administration routes & could inform interpretation of results. The detection window was much shorter for MT in dried blood spots vs metabolites in urine.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1...
This image shows details about the paper linked in the post. It was published in the journal Drug Testing and Analysis, and the title of the paper is, "Distinguishing Between Oral and Transdermal Administration Routes of Methyltestosterone Through Human Urine and Dried Blood Spot Analyses for Doping Control Purposes".
December 19, 2025 at 3:11 PM
pccantidoping.bsky.social
What are the benefits of remote sampling in #antidoping ? Dr. Daniel Westmattelmann discusses his transition from a professional cyclist to anti-doping research, as well as the outcomes of his PCC-funded project to implement a remote sampling system.

cleancompetition.org/anti-doping-...
164 - Investigating Remote Sampling, Sample Retention and Re-Analysis, and Athlete Experiences in Anti-Doping - Daniel Westmattelmann, PhD - PCC - Global Anti-Doping Research Grants for Scientists and...
0.75x 1x 1.25x 1.5x 2x 0:0042:53 164 – Investigating Remote Sampling, Sample Retention and Re-Analysis, and Athlete Experiences in Anti-Doping – Daniel Westmattelmann, PhD Apple PodcastsGoogle Podcast...
cleancompetition.org
December 17, 2025 at 4:44 PM
pccantidoping.bsky.social
In this PCC-funded project, authors examined the urinary excretion profile of trenbolone and its metabolites after oral, transdermal, and buccal administration. They identified a metabolite that was more abundant after transdermal and buccal administration. 🚫💊 🧪
www.sciencedirect.com/science/arti...
The influence of the route of drug administration on the metabolic profile of trenbolone in doping control urine samples
Advances in analytical techniques have markedly improved the detection of anabolic–androgenic steroids (AAS) in doping controls. This represents a maj…
www.sciencedirect.com
December 15, 2025 at 7:06 PM
pccantidoping.bsky.social
Authors developed & validated a high-throughput method to screen for 30 steroid esters and a confirmatory method for 26 targets using dried blood spots. This could be an efficient, sensitive, & automated way to differentiate between endogenous & synthetic steroids. 🚫💊 🧪

pubs.acs.org/doi/10.1021/...
Modified Fully Automated Dried Blood Spot Sample Preparation System and Its Application in Steroid Ester Detection
The detection of anabolic androgenic steroids (AAS) remains a significant challenge in antidoping, particularly in distinguishing endogenous steroids from their synthetic counterparts. Although isotop...
pubs.acs.org
December 12, 2025 at 3:54 PM
pccantidoping.bsky.social
How can we make the most of limited resources in #antidoping? Authors developed a framework that assesses the potential performance-enhancing effects of substance categories across 6 physiological demands & maps the effects to the physiological profiles of 160 sport disciplines.
tinyurl.com/muxtah38
Mapping of the Pharmacological Effect of Prohibited Substances and Methods to Athletic Physiological Characteristics
Expected performance benefits for each prohibited substance/method has been presented. Several disciplines are highlighted as an example. The y$$ y $$-axis is ordered by the median benefit score.
analyticalsciencejournals.onlinelibrary.wiley.com
December 10, 2025 at 4:51 PM
pccantidoping.bsky.social
What does it take to run a successful WADA-accredited anti-doping lab? Dr. Rosa Ventura Alemany provides a behind-the-scenes look at the excellent work she & colleagues are doing at the Catalonian #Antidoping Laboratory in research & routine testing. 👩‍🔬 🧪

cleancompetition.org/anti-doping-podcast/163
The image features a headshot photo of Rosa Ventura Alemany, PhD, Director of the Catalonian Anti-Doping Laboratory, as well as a quote from her interview on the Partnership for Clean Competition's Anti-Doping Podcast: "Running an accredited lab is extremely demanding. It operates in a highly regulated environment, and we are always in a process of continuous improvement. We constantly have to keep up with new substances and analytical methods, maintaining the highest scientific standards. We also need to invest heavily in advanced instruments and also in skilled staff. In addition, our results must be legally defensible. On top of that, we handle a large number of samples under tight deadlines. It means that the lab has to always work under perfect conditions."
December 9, 2025 at 6:04 PM
pccantidoping.bsky.social
Growth hormone-releasing hormone & synthetic analogs are prohibited in sport, but hard to detect w/ traditional urine analyses. Authors developed & validated a new method & workflow that is sensitive, specific & reliable for detecting & confirming the target peptides in urine. 🧪
tinyurl.com/48hxtv38
Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry
Growth hormone-releasing hormone (GHRH) and its synthetic analogs are considered performance-enhancing substances and are therefore prohibited by the …
www.sciencedirect.com
December 4, 2025 at 5:14 PM
pccantidoping.bsky.social
Celebrating its 40th anniversary this year, the Catalonian Anti-Doping Laboratory has made a myriad of contributions to #cleansport. Dr. Rosa Ventura Alemany shared the lab's history, current #antidoping research projects, and more in a new podcast episode:
cleancompetition.org/anti-doping-...
163 - 40 Years of Advancing Anti-Doping at the Catalonia Anti-Doping Laboratory - Rosa Ventura Alemany, PhD - PCC - Global Anti-Doping Research Grants for Scientists and Researchers
0.75x 1x 1.25x 1.5x 2x 0:0037:42 163 – 40 Years of Advancing Anti-Doping at the Catalonia Anti-Doping Laboratory – Rosa Ventura Alemany, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a Revi...
cleancompetition.org
December 2, 2025 at 6:31 PM
pccantidoping.bsky.social
Authors found CERAs (used in blood doping) are more stable & detectable w/ serum & dried blood spots (DBS) vs urine. Flagged Athlete Biological Passport changes in reticulocyte % also support targeted serum tests & lead to detection.

analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
CERA Detection and Stability in Blood Versus Urine
This study presents comparative data on CERA detection in serum and urine samples, highlighting adverse analytical findings (AAFs) in serum that were undetected in corresponding urine samples. This s...
analyticalsciencejournals.onlinelibrary.wiley.com
December 1, 2025 at 5:07 PM
pccantidoping.bsky.social
We're pleased to highlight a recent PCC-funded research project, led by Dr. Martin Bidlingmaier, to examine soluble alpha klotho (sαKL) as a potential marker of growth hormone (GH) doping. sαKL is a protein in blood & urine that is impacted in clinical conditions with excess or deficient GH levels.
The text reads, "PCC-Funded Research Spotlight, Grant Title: Soluble Alpha Klotho - A New Biomarker to Detect Growth Hormone Doping, Dr. Martin Bidlingmaier, Ludwig-Maximilians-University of Munich". There is a headshot photo of Dr. Bidlingmaier on the right above the text logo for the Partnership for Clean Competition.
November 28, 2025 at 7:41 PM
pccantidoping.bsky.social
"Brain doping" is gaining attention in sport, & this review identified only 9 studies on brain doping substances shown to ⬆️ sports performance. They also examined active ingredients that promote cognition in supplements to see how they fit w/in #antidoping rules.
pmc.ncbi.nlm.nih.gov/articles/PMC...
This image shows details about the paper linked in the post. It was published in the journal Biology of Sport, and the article title is, "Brain doping" substances: prohibited or not in sports?
November 26, 2025 at 5:36 PM
pccantidoping.bsky.social
Dr. John Eiler is using #massspectrometry technology to identify the exact locations of isotopes in atoms in a PCC-funded research project to detect the molecular isotopic structures of substances in #antidoping samples.

Learn more in our latest podcast episode:
cleancompetition.org/anti-doping-...
There is a photo of Dr. John Eiler in the lower left. His name and titles are included in the bottom right. The text logo of the Partnership for Clean Competition appears at the top above the words, "The Anti-Doping Podcast". Below, there is a quote from Dr. Eiler's episode: "When you study in this way, you first of all have a highly specific fingerprint. Something that can’t be faked. Second, you have a very mechanistic fingerprint. It tells you how the system was being dysregulated. And third… it’s a persistent change that may be very easy to detect later than some of the more familiar tests. When they stop working, maybe our test will keep working.”
November 25, 2025 at 5:19 PM
pccantidoping.bsky.social
Performance-enhancing drugs compromise the integrity of sport, and they can cause a wide range of negative health effects. This recent review article examines the latest evidence surrounding the negative cardiovascular effects of doping.

www.minervamedica.it/en/journals/...
#antidoping #science
The cardiovascular risk of doping and substance abuse in athletes - The Journal of Sports Medicine and Physical Fitness 2025 October;65(10):1401-12
The cardiovascular risk of doping and substance abuse in athletes
www.minervamedica.it
November 24, 2025 at 7:22 PM
pccantidoping.bsky.social
An increasing body of research supports that tDCS impacts endurance, strength, skill acquisition & perceived exertion. This recent editorial discusses how tDCS works, what we know about its ergogenic effects, & how it may fit within the framework of “neurodoping”. 🧪
pubmed.ncbi.nlm.nih.gov/41078301/
This image provides details about the open access article linked in the post. It was published in the journal Advances in Clinical and Experimental Medicine, and the title of the article is, "Transcranial direct current stimulation (tDCS): A new, (still) legal form of "neurodoping" in sports?"
November 21, 2025 at 5:04 PM
pccantidoping.bsky.social
The synthetic steroidal SARM S42 is prohibited in sport due to potential performance-enhancing effects. To improve detection of S42 misuse, the PCC funded a research project, led by Dr. Mario Thevis, to investigate the metabolism of S42 to inform the development of new #antidoping detection methods.
The text reads, "PCC-Funded Research Spotlight, Grant Title: Investigations into the metabolism and detection of the novel SARM S42, Dr. Mario Thevis, German Sort University Cologne". There is a photo of Dr. Thevis on the right, above the text logo for the Partnership for Clean Competition.
November 21, 2025 at 4:51 PM
pccantidoping.bsky.social
Authors developed a rapid method using a CRISPR/CAS-based assay & double emulsion droplets to detect human erythropoietin gene doping. They validated the approach in spiked serum samples, & their results show excellent sensitivity & specificity. 🚫💊 🧪

advanced.onlinelibrary.wiley.com/doi/10.1002/...
This image shows more details about the paper linked in the post. It was published in the journal Advanced Science, and the title is, "Osmotically Tunable Microdroplets Enable Amplification-Free CRISPR Detection of Gene Doping".
November 19, 2025 at 6:16 PM
pccantidoping.bsky.social
How can approaches from geosciences advance #antidoping? Dr. John Eiler discusses his research, a recent PCC-funded project examining use of molecular isotopic structure for doping forensics, promising new results, and the potential impacts of this work. 🚫💊 🧪

cleancompetition.org/anti-doping-...
162 - Leveraging Molecular Isotopic Structure in Anti-Doping Analyses - John Eiler, PhD - PCC - Global Anti-Doping Research Grants for Scientists and Researchers
0.75x 1x 1.25x 1.5x 2x 0:0056:13 162 – Leveraging Molecular Isotopic Structure in Anti-Doping Analyses – John Eiler, PhD Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a ReviewListen in a New Wi...
cleancompetition.org
November 18, 2025 at 4:25 PM
pccantidoping.bsky.social
SARMs are increasingly detected in #antidoping analyses, & in-depth drug characterization can help understand health risks & improve detection. Authors examined the absorption, distribution, metabolism, & excretion of the novel non-steroidal SARM ACP-105. 🧪

link.springer.com/article/10.1...
First multifaceted ADME profile of ACP-105 (CAS: 1048998-11-3): a novel non-steroidal selective androgen receptor modulator used as doping in sports—integrative in silico toxicological studies for cli...
ACP-105 (CAS: 1048998-11-3) is a novel non-steroidal selective androgen receptor modulator (SARM), increasingly detected in anti-doping analyses, yet lacking a comprehensive ADME profile. This study p...
link.springer.com
November 17, 2025 at 5:18 PM
pccantidoping.bsky.social
Roxadustat has erythropoietic, cardioprotective, and metabolic regulatory effects and is prohibited in sport. This review details what we know about its mechanisms of action, legitimate clinical uses, how it can be detected in #antidoping analyses, and more. 🧪

pmc.ncbi.nlm.nih.gov/articles/PMC...
This image provides details about the paper linked in the post. It was published in Current Issues in Molecular Biology, and the title of the paper is, "Roxadustat as a Hypoxia-Mimetic Agent: Erythropoietic Mechanisms, Bioanalytical Detection, and Regulatory Considerations in Sports Medicine".
November 14, 2025 at 4:33 PM