Kevin Baker
@orthoengineer.bsky.social
Husband | Father | Assoc. Scientist @hfhs-bjc.bsky.social, Assoc. Professor @ Michigan State CHM | Orthopaedic Research (mostly osteoarthritis and intervertebral disc degeneration) | All things: #Detroit, U.P., Great Lakes Freighters, Local Sports
Pinned
ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!
Who says PIs dont stand by their posters!? Presenting our ACL reconstruction research at #TERMISAM2025 in #Detroit.
November 10, 2025 at 8:34 PM
Who says PIs dont stand by their posters!? Presenting our ACL reconstruction research at #TERMISAM2025 in #Detroit.
Fantastic time at the 18th World Congress of the International Cartilage Regeneration & Joint Preservation Society in Boston. Presented our work on IDO-1 and #Kynurenines in #osteoarthritis, and a project focused on improved healing in #ACL reconstruction. As always - huge thanks to the team!
October 17, 2025 at 5:05 PM
Fantastic time at the 18th World Congress of the International Cartilage Regeneration & Joint Preservation Society in Boston. Presented our work on IDO-1 and #Kynurenines in #osteoarthritis, and a project focused on improved healing in #ACL reconstruction. As always - huge thanks to the team!
Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!
🚨🚨 New Publication Alert: The Ali Lab published a review on advancements in genomics, genetics, and epigenetics of #osteoarthritis. Fantastic work Thomas Wilson, Madhu Baghel and @amandality.bsky.social!
www.oarsijournal.com/article/S106...
www.oarsijournal.com/article/S106...
Osteoarthritis year in review 2025: Genetics, genomics, and epigenetics
This review provides an overview of the work performed in the realms of genetics,
genomics and epigenetics in osteoarthritis (OA) research over the past year.
www.oarsijournal.com
September 20, 2025 at 2:10 PM
Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!
Sharing our new publication on the topic of recruiting endogenous, pharmacologically-mobilized MSCs to degenerative lumbar intervertebral discs. Early results but step in the right direction! 1/
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Local RANTES/CCL5 Delivery and Peripheral Blood Mobilization of Endogenous Marrow-Derived Mesenchymal Stem Cells to Mitigate Lumbar Intervertebral Disc Degeneration - Sapan Gandhi, Christopher S. Lai,...
Study Design Translational rodent study. Objectives To investigate (1) chemokine-mediated mesenchymal stem cell mobilization and homing to the intervertebral d...
journals.sagepub.com
September 2, 2025 at 2:35 PM
Sharing our new publication on the topic of recruiting endogenous, pharmacologically-mobilized MSCs to degenerative lumbar intervertebral discs. Early results but step in the right direction! 1/
journals.sagepub.com/doi/full/10....
journals.sagepub.com/doi/full/10....
Amazing #fishing trip to Northern Ontario with K1 before he moves in @umich.edu next week! 🥹
August 16, 2025 at 9:12 PM
Amazing #fishing trip to Northern Ontario with K1 before he moves in @umich.edu next week! 🥹
More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.
🚨🚨New publication alert! The Ali Lab @amandality.bsky.social in the @hfhs-bjc.bsky.social uses sequencing to profile microRNAs in early-stages of both osteoarthritis and rheumatoid arthritis! Now published in Scientific Reports @natureportfolio.nature.com, read it here: rdcu.be/eylic
Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis
Scientific Reports - Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis
rdcu.be
July 31, 2025 at 2:18 PM
More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.
Excited to put this new system to good use, and thankful for the rich history of uCT imaging here @hfhs-bjc.bsky.social from the Yeni Lab. Looking forward to some fun contrast-enhanced imaging of articular cartilage and intervertebral disc! #orthosky
The Henry Ford Health Bone & Joint Center has a storied history with microCT imaging of MSK tissues, thanks primarily to Dr. Yeni's group. Today we took a large leap forward with the installation of a brand new Scanco MicroCT-90 system! #orthopaedics #imaging #bone #cartilage
July 26, 2025 at 12:55 AM
Excited to put this new system to good use, and thankful for the rich history of uCT imaging here @hfhs-bjc.bsky.social from the Yeni Lab. Looking forward to some fun contrast-enhanced imaging of articular cartilage and intervertebral disc! #orthosky
The @tigers.bsky.social are on a 6 game skid. The @detroitlions.bsky.social are in mid-season form with injuries nearly everyday. Only 6 more Saturdays until @umichfball.bsky.social, though!
July 20, 2025 at 3:40 PM
The @tigers.bsky.social are on a 6 game skid. The @detroitlions.bsky.social are in mid-season form with injuries nearly everyday. Only 6 more Saturdays until @umichfball.bsky.social, though!
We got some fishing in on the Huron River yesterday in Ann Arbor after K1 finished new student orientation @umich.edu.
July 16, 2025 at 4:59 PM
We got some fishing in on the Huron River yesterday in Ann Arbor after K1 finished new student orientation @umich.edu.
This was a fantastic opportunity to strengthen ties with our @michiganstateu.bsky.social colleagues! Grateful to be able to share our stem cell mobilization work. Many thanks to the Co-Chairs @amandality.bsky.social @mattharkeyphd.bsky.social, Charles Day MD and Jane Manfredi DVM PhD!
Members of the Bone & Joint Center had a great time sharing and learning about musculoskeletal research at @michiganstateu.bsky.social and @henryfordhealth.bsky.social during the HFH+MSU Musculoskeletal Research Retreat. Our Chairman @shouldergeek.bsky.social delivered inspiring opening remarks!
June 23, 2025 at 2:14 PM
This was a fantastic opportunity to strengthen ties with our @michiganstateu.bsky.social colleagues! Grateful to be able to share our stem cell mobilization work. Many thanks to the Co-Chairs @amandality.bsky.social @mattharkeyphd.bsky.social, Charles Day MD and Jane Manfredi DVM PhD!
Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here:
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
May 30, 2025 at 2:06 PM
Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here:
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Tariff on the new microCT we purchased will be somewhere between 0 and 32%. Cool. Cool, cool.
May 19, 2025 at 9:51 PM
Tariff on the new microCT we purchased will be somewhere between 0 and 32%. Cool. Cool, cool.
Reposted by Kevin Baker
Another fantastic @henryfordhealth.bsky.social Research Symposium in the books! Inspiring to hear about all of the awesome research from across the campus. Equally amazing to hear from @boneybonebone.bsky.social of the Yeni Lab @hfhs-bjc.bsky.social talking about facet joint measurement via DTS!
May 10, 2025 at 2:27 AM
Another fantastic @henryfordhealth.bsky.social Research Symposium in the books! Inspiring to hear about all of the awesome research from across the campus. Equally amazing to hear from @boneybonebone.bsky.social of the Yeni Lab @hfhs-bjc.bsky.social talking about facet joint measurement via DTS!
K1 sent pics below of the 🇳🇱 flagged Iver Bright tanker (left) and the 989 ft. M/V American Century diesel-powered freighter (right) while fishing on the St. Clair River.
March 27, 2025 at 12:50 AM
K1 sent pics below of the 🇳🇱 flagged Iver Bright tanker (left) and the 989 ft. M/V American Century diesel-powered freighter (right) while fishing on the St. Clair River.
A new manuscript acceptance was a much needed win this week. So grateful to work with smart people! More to come on the accepted manuscript once proofs are up. For now, I'll just say that it is pretty cool that we can convince cells to go to specific places...like the #rotatorcuff maybe?
shrek from the movie shrek looks at the camera
ALT: shrek from the movie shrek looks at the camera
media.tenor.com
March 20, 2025 at 5:54 PM
A new manuscript acceptance was a much needed win this week. So grateful to work with smart people! More to come on the accepted manuscript once proofs are up. For now, I'll just say that it is pretty cool that we can convince cells to go to specific places...like the #rotatorcuff maybe?
With the @tigers.bsky.social home opener less than two weeks away, it's time to channel Sparky Anderson. #GrittyTigers #Detroit
March 14, 2025 at 1:10 PM
With the @tigers.bsky.social home opener less than two weeks away, it's time to channel Sparky Anderson. #GrittyTigers #Detroit
Great paper from @boneybonebone.bsky.social of the Yeni Lab in the @hfhs-bjc.bsky.social. DTS could be very useful for understanding facet joint loading associated with spondyloarthropathies, or even new interbody or interspinous spacer devices! #Orthosky #Spine
New paper from Dr. Yeni, @boneybonebone.bsky.social, et al. just published in @jbiomech.bsky.social! The team used digital tomosynthesis (DTS) to quantify spinal facet joint width. They also showed that this technique can be used in vivo to dynamically observe human facet joint loading! #Orthosky
March 1, 2025 at 7:37 PM
Great paper from @boneybonebone.bsky.social of the Yeni Lab in the @hfhs-bjc.bsky.social. DTS could be very useful for understanding facet joint loading associated with spondyloarthropathies, or even new interbody or interspinous spacer devices! #Orthosky #Spine
Grateful to be a (very) small part of such an amazing study! All credit to the awesome @amandality.bsky.social and her team for this important #osteoarthritis discovery just published in @naturecomms.bsky.social. The miR-evolution is now!
Excited to share our work on the small but mighty microRNA-126-3p in @naturecomms.bsky.social! We found this microRNA is elevated in four knee osteoarthritis cohorts and show in an animal model that it reduces the severity of knee osteoarthritis - at least in part via angiogenesis. rdcu.be/ebycj
February 27, 2025 at 10:00 PM
Grateful to be a (very) small part of such an amazing study! All credit to the awesome @amandality.bsky.social and her team for this important #osteoarthritis discovery just published in @naturecomms.bsky.social. The miR-evolution is now!
Gracie often embodies Monday vibes.
February 24, 2025 at 11:22 PM
Gracie often embodies Monday vibes.
A very Detroit end to day spent helping some neighbors. Spotted this pheasant pair just off Kercheval and Field. (Sorry for the poor quality)
February 15, 2025 at 5:35 PM
A very Detroit end to day spent helping some neighbors. Spotted this pheasant pair just off Kercheval and Field. (Sorry for the poor quality)
ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!
February 4, 2025 at 4:54 PM
ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!
Our folks just sent pictures of the St. Clair River in East China, Michigan. Lots of ice piling up and the CGC Mackinaw cutting a path.
January 25, 2025 at 7:10 PM
Our folks just sent pictures of the St. Clair River in East China, Michigan. Lots of ice piling up and the CGC Mackinaw cutting a path.
Was great to be back at @michigantech.bsky.social and hanging in the Keweenaw Peninsula again for a few days!
January 18, 2025 at 10:24 PM
Was great to be back at @michigantech.bsky.social and hanging in the Keweenaw Peninsula again for a few days!
We knew during training camp that the @detroitlions.bsky.social would be Kings of the North again this season!! #OnePride #Detroit
January 6, 2025 at 4:55 AM
We knew during training camp that the @detroitlions.bsky.social would be Kings of the North again this season!! #OnePride #Detroit
That is a whole lot of wires and boards for some nugget ice. File under: reasons I didn't become an EE.
January 4, 2025 at 9:12 PM
That is a whole lot of wires and boards for some nugget ice. File under: reasons I didn't become an EE.