Olga Pushkarev
@opushkarev.bsky.social
SNSF Postdoc @Stanford Genetics
Comp bio + gene regulation🧬
prev. PhD @EPFL🇨🇭& ESR @ENHPATHY🇪🇺
Comp bio + gene regulation🧬
prev. PhD @EPFL🇨🇭& ESR @ENHPATHY🇪🇺
Paired high-resolution imaging and scRNA-seq made possible 📸+🧬 Impressive work by the team, and so many exciting possibilities ahead!
We just released IRIS (7+yrs project), a tech we believe will transform cell biology by pairing high-resolution cell images with matched #scRNAseq, letting us interpret cellular form by its molecular ground truth.
Huge tx to @JohannesBues, @JoernPezoldt, @CamilleLambert et al.
shorturl.at/zgY8Z
Huge tx to @JohannesBues, @JoernPezoldt, @CamilleLambert et al.
shorturl.at/zgY8Z
December 4, 2025 at 1:04 PM
Paired high-resolution imaging and scRNA-seq made possible 📸+🧬 Impressive work by the team, and so many exciting possibilities ahead!
Reposted by Olga Pushkarev
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
www.nature.com
October 6, 2025 at 6:57 AM
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China