European Journal of Ophthalmology, Ahead of Print. IntroductionTo report a rare case of a 71-year-old male with bilateral butterfly-shaped pattern dystrophy (BPD) who developed a retinal pigment epithelium (RPE) tear in the left eye. Pattern dystrophies are a group of autosomal dominant macular diseases ...

European Journal of Ophthalmology, Ahead of Print. PurposeCongenital cataracts (CC) are a preventable cause of childhood blindness, accounting for approximately 10% of cases. A significant portion of CC cases remains idiopathic. Genetic diagnosis can eliminate unnecessary tests and ensure appropriate ...

European Journal of Ophthalmology, Ahead of Print. PurposeTo present a case of non-uveal intraocular metastatic disease originating from relapsed breast carcinoma.MethodsWe report a 67-year-old female with a history of HER2-positive breast carcinoma in remission and recent squamous cell carcinoma of the ...

European Journal of Ophthalmology, Ahead of Print. ObjectiveTo evaluate the safety and efficacy of MicroPulse Transscleral Laser Therapy (MicroPulse TLT) with the Revised P3®Delivery Device.DesignProspective, single-surgeon, interventional study in a tertiary hospital setting.ParticipantsSixty-two eyes ...

Objective To assess the interchangeability of minimum linear diameter (MLD) macular hole (MH) size measurements in high-density horizontal and radial scan modes in optical coherence tomography (OCT). Methods and analysis 60 patients with a MH had repeat high-density OCT volume scans in a horizontal (30 µm interscan-spacing) and a radial (angular 3.75° interscan-spacing) mode, and the MLD was measured by five raters. Results There were no significant differences in the MLD measurements within the horizontal and the radial modes across repeat measurements of each rater in volume scan 1 (all p≥0.14 and p≥0.28, respectively), between volume scans 1 and 2 (all p≥0.14 and p≥0.69), among the raters (p=0.70 and p=0.60), and using all MLD measurements obtained in this study between primary and repeat measurements in volume scan 1 (p=0.10 and p=0.74) and between measurements obtained in volume scan 1 and 2 (p=0.21 and p=0.90). There was a statistically significant difference of –10.05 µm between the mean MLD of all measurements in the horizontal (n=900) and in the radial (n=900) mode (427.91 (±187.01) vs 437.97 (±184.93) µm; p<0.001). However, the variability of these differences around the mean MLD was large (95% limits of agreement –77.31 to 57.21 µm). The mean difference between all horizontal and all radial MLD measurements in a MH was for MHs that had their widest MLD within 15° of the horizontal, vertical and diagonal meridians 0.77 (±13.88) µm, –34.43 (±55.22) µm and –10.39 (± 34.62) µm, respectively. Conclusions Horizontal scans systematically underestimate the maximum MLD if located vertically or diagonally; however, they have less intra-rater and inter-rater and inter-scan variability in MLD measurements as compared with radial scans. Therefore, the two scan modes are not interchangeable but rather complement each other. These results may be limited to the MLD range analysed (125–924 µm).

Objective This study validated the artificial intelligence (AI)-based algorithm LuxIA for screening more-than-mild diabetic retinopathy (mtmDR) from a single 45° colour fundus image of patients with diabetes mellitus (DM, type 1 or type 2) in Spain. Secondary objectives included validating LuxIA according to the International Clinical Diabetic Retinopathy (ICDR) classification and comparing its performance between different devices. Methods In this multicentre, cross-sectional study, retinal colour fundus images of adults (≥18 years) with DM were collected from five hospitals in Spain (December 2021–December 2022). 45° colour fundus photographs were captured using non-mydriatic Topcon and ZEISS cameras. The Discovery platform (RetinAI) was used to collect images. LuxIA output was an ordinal score (1–5), indicating a classification as mtmDR based on an ICDR severity score. Results 945 patients with DM were included; the mean (SD) age was 64.6 (13.5) years. The LuxIA algorithm detected mtmDR with a sensitivity and specificity of 97.1% and 94.8%, respectively. The area under the receiver-operating characteristic curve was 0.96, indicating a high test accuracy. The 95% CI data for overall accuracy (94.8% to 95.6%), sensitivity (96.8% to 98.2%) and specificity (94.3% to 95.1%) indicated robust estimations by LuxIA, which maintained a concordance of classification (N=829, kappa=0.837, p=0.001) when used to classify Topcon images. LuxIA validation on ZEISS-obtained images demonstrated high accuracy (90.6%), specificity (92.3%) and lower sensitivity (83.3%) as compared with Topcon-obtained images. Conclusions AI algorithms such as LuxIA are increasing testing feasibility for healthcare professionals in DR screening. This study validates the real-world utility of LuxIA for mtmDR screening.

European Journal of Ophthalmology, Ahead of Print. PurposeTo identify parameters that are significant risk predictors of visual field (VF) progression in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG), using Goldmann applanation tonometry intraocular pressure (IOP-GAT),...

European Journal of Ophthalmology, Ahead of Print. PurposeTo report a case of a patient diagnosed with corneal intraepithelial neoplasia (CIN) with ocular discomfort and blurred vision, successfully treated with alcohol delamination (ALD) and topical mitomycin-C.MethodsA 69 year-old man underwent a full ...

European Journal of Ophthalmology, Ahead of Print. PurposeTo present a case of simultaneous bilateral corneal perforation in a patient affected by Sjögren syndrome (SjS) successfully managed with corneal transplantation on the left eye and placing an autologous corneal patch on the right eye.ObservationsA ...

European Journal of Ophthalmology, Ahead of Print. Purpose:The purpose of this study is to investigate the correlation of lens parameters and choroidal thickness (RCS) with the severity of PACD and to compare those parameters with the normal population.Methods:Prospective, cross-sectional hospital-...

European Journal of Ophthalmology, Ahead of Print. PurposeThe pachychoroid disease spectrum is characterized by choroidal thickening, vascular hyperpermeability, and structural alterations in the choroidal circulation. This can lead to central serous chorioretinopathy (CSC), which is clinically seen as ...

European Journal of Ophthalmology, Ahead of Print. PurposeTo evaluate the macular pigment optical density (MPOD) in dry age-related macular degeneration (AMD).MethodsThis prospective study included 68 dry AMD patients and, as the control group, 91 healthy volunteers. Age, gender, family history, smoking, ...