Nikos Louros
@nlouros.bsky.social
Assistant Professor of Biophysics | Center for Alzheimer's and Neurodegenerative Diseases (CAND), UT Southwestern Medical Center (UTSW) | Protein misfolding / Amyloid formation / Neurodegenerative diseases 🧠 / AI/ML protein engineering | 🇬🇷/🇬🇧
🚀 Our new preprint is out!
We uncover that TAF15 forms amyloids that propagate in a prion-like manner via defined APR motifs.
• First TAF15 cell biosensor
• Prion-like TAF15 propagation
• Mapping TAF15 aggregation propensity
🔗 www.biorxiv.org/content/10.1...
We uncover that TAF15 forms amyloids that propagate in a prion-like manner via defined APR motifs.
• First TAF15 cell biosensor
• Prion-like TAF15 propagation
• Mapping TAF15 aggregation propensity
🔗 www.biorxiv.org/content/10.1...
TAF15 amyloids propagate via defined motifs in a prion-like fashion
TATA-box binding protein-associated factor 15 (TAF15) is an RNA-binding member of the FET family recently identified as the primary fibrillar constituent in a subset of frontotemporal lobar degenerati...
www.biorxiv.org
November 19, 2025 at 3:33 PM
🚀 Our new preprint is out!
We uncover that TAF15 forms amyloids that propagate in a prion-like manner via defined APR motifs.
• First TAF15 cell biosensor
• Prion-like TAF15 propagation
• Mapping TAF15 aggregation propensity
🔗 www.biorxiv.org/content/10.1...
We uncover that TAF15 forms amyloids that propagate in a prion-like manner via defined APR motifs.
• First TAF15 cell biosensor
• Prion-like TAF15 propagation
• Mapping TAF15 aggregation propensity
🔗 www.biorxiv.org/content/10.1...
🚨Thrilled our work is out in @NatureComm!🚨
Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs.
Read the full paper: doi.org/10.1038/s414...
Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs.
Read the full paper: doi.org/10.1038/s414...
Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation - Nature Communications
Energetic profiling of cryo-EM time series for IAPP, tau, and α-synuclein reveals how amyloid fibril maturation is driven by sequence-encoded hotspots. Rearrangement of APRs anchors growth, while cofa...
doi.org
November 18, 2025 at 4:20 PM
🚨Thrilled our work is out in @NatureComm!🚨
Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs.
Read the full paper: doi.org/10.1038/s414...
Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs.
Read the full paper: doi.org/10.1038/s414...
🚨Preprint alert! 🚨
Proud to share Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles. Huge thanks to our members of the lab, as well as the always great Joost Schymkowitz, Frederic Rousseau (VIB–KU Leuven).
www.biorxiv.org/content/10.1...
Proud to share Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles. Huge thanks to our members of the lab, as well as the always great Joost Schymkowitz, Frederic Rousseau (VIB–KU Leuven).
www.biorxiv.org/content/10.1...
Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles
Amyloid fibrils underpin both functional and pathological protein assemblies and exhibit extensive structural polymorphism. More than 600 high-resolution fibril structures are now available across ove...
www.biorxiv.org
October 16, 2025 at 2:54 PM
🚨Preprint alert! 🚨
Proud to share Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles. Huge thanks to our members of the lab, as well as the always great Joost Schymkowitz, Frederic Rousseau (VIB–KU Leuven).
www.biorxiv.org/content/10.1...
Proud to share Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles. Huge thanks to our members of the lab, as well as the always great Joost Schymkowitz, Frederic Rousseau (VIB–KU Leuven).
www.biorxiv.org/content/10.1...
🚨Our work in Structure!🚨
Overview of the expanding toolkit for amyloid structures: from topology clustering to residue-level energetics & cofactor mapping. Conserved hotspots form isoenergetic folds, environment biases fold selection & shapes disease strains. www.sciencedirect.com/science/arti...
Overview of the expanding toolkit for amyloid structures: from topology clustering to residue-level energetics & cofactor mapping. Conserved hotspots form isoenergetic folds, environment biases fold selection & shapes disease strains. www.sciencedirect.com/science/arti...
Toward a thermodynamic taxonomy of amyloid fibrils
In this issue of Structure, Connor et al.1 combine topology and residue-level energetics of α-synuclein and tau fibrils to identify isoenergetic fold …
www.sciencedirect.com
October 2, 2025 at 3:21 PM
🚨Our work in Structure!🚨
Overview of the expanding toolkit for amyloid structures: from topology clustering to residue-level energetics & cofactor mapping. Conserved hotspots form isoenergetic folds, environment biases fold selection & shapes disease strains. www.sciencedirect.com/science/arti...
Overview of the expanding toolkit for amyloid structures: from topology clustering to residue-level energetics & cofactor mapping. Conserved hotspots form isoenergetic folds, environment biases fold selection & shapes disease strains. www.sciencedirect.com/science/arti...
Reposted by Nikos Louros
💬 I’m grateful for the help of an incredible team of collaborators, Senthil Kumar Thangaraj
@wagnerjessica.bsky.social
@rodrigoagallardo.bsky.social
Gabriele Orlando Matthias De Vleeschouwer Jillian Madine
@nlouros.bsky.social
@jonasneher.bsky.social
@wagnerjessica.bsky.social
@rodrigoagallardo.bsky.social
Gabriele Orlando Matthias De Vleeschouwer Jillian Madine
@nlouros.bsky.social
@jonasneher.bsky.social
July 26, 2025 at 11:24 AM
💬 I’m grateful for the help of an incredible team of collaborators, Senthil Kumar Thangaraj
@wagnerjessica.bsky.social
@rodrigoagallardo.bsky.social
Gabriele Orlando Matthias De Vleeschouwer Jillian Madine
@nlouros.bsky.social
@jonasneher.bsky.social
@wagnerjessica.bsky.social
@rodrigoagallardo.bsky.social
Gabriele Orlando Matthias De Vleeschouwer Jillian Madine
@nlouros.bsky.social
@jonasneher.bsky.social
🚨New Preprint Alert🚨
Collaborative effort from my post‑doc days at @vib-switch-lab.bsky.social, so many brilliant colleagues came together to show how medin steers Aβ40 toward Aβ42‑like fibril polymorphs. Grateful to have played a part!
www.biorxiv.org/content/10.1... #amyloid #Alzheimers
Collaborative effort from my post‑doc days at @vib-switch-lab.bsky.social, so many brilliant colleagues came together to show how medin steers Aβ40 toward Aβ42‑like fibril polymorphs. Grateful to have played a part!
www.biorxiv.org/content/10.1... #amyloid #Alzheimers
Medin drives Aβ40 to adopt Aβ42-like fibril polymorphs in vitro
Medin, a vascular amyloid derived from MFG-E8, is the most prevalent form of localized human amyloid and co-localizes with Aβ in Alzheimer’s disease and, in particular, cerebral amyloid angiopathy (CA...
www.biorxiv.org
July 25, 2025 at 8:56 PM
🚨New Preprint Alert🚨
Collaborative effort from my post‑doc days at @vib-switch-lab.bsky.social, so many brilliant colleagues came together to show how medin steers Aβ40 toward Aβ42‑like fibril polymorphs. Grateful to have played a part!
www.biorxiv.org/content/10.1... #amyloid #Alzheimers
Collaborative effort from my post‑doc days at @vib-switch-lab.bsky.social, so many brilliant colleagues came together to show how medin steers Aβ40 toward Aβ42‑like fibril polymorphs. Grateful to have played a part!
www.biorxiv.org/content/10.1... #amyloid #Alzheimers
🚨New lab preprint!🚨
Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge.
www.biorxiv.org/content/10.1...
Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge.
www.biorxiv.org/content/10.1...
Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation
Amyloid fibrils adopt diverse structural polymorphs that underlie disease-specific phenotypes, but the thermodynamic principles guiding their formation and maturation remain poorly understood. Here, w...
www.biorxiv.org
May 16, 2025 at 4:31 PM
🚨New lab preprint!🚨
Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge.
www.biorxiv.org/content/10.1...
Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge.
www.biorxiv.org/content/10.1...
Reposted by Nikos Louros
Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
March 20, 2025 at 7:56 AM
Exciting News! We’re thrilled to announce the first Functional Amyloid Meeting at DESY!
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Join us for a deep dive into the latest breakthroughs in functional fibrils, with a spotlight on amyloid molecular and cellular mechanisms and their biomedical applications.
landau-cssb.de/meeting-of-f...
Louros lab group photo in the CAND (2025)
March 4, 2025 at 10:16 PM
Louros lab group photo in the CAND (2025)