@nilimesh.bsky.social
Postdoc in Boston Children's Hospital & Harvard Medical School
Phd at IIT Kanpur, India
Currently, probing how FUS, SMC-5/6 & DDX6 shape transcription, DNA, and condensates
Phd at IIT Kanpur, India
Currently, probing how FUS, SMC-5/6 & DDX6 shape transcription, DNA, and condensates
Cryo-EM snapshots of Wadjet show how ATP fuels a 360° dimer rotation to trap DNA and set the stage for loop extrusion
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 31, 2025 at 3:56 PM
Cryo-EM snapshots of Wadjet show how ATP fuels a 360° dimer rotation to trap DNA and set the stage for loop extrusion
You don't need all 20 amino acids to build proteins! Here, authors showed
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
Ancient amino acid sets enable stable protein folds
Early proteins likely arose from a chemically limited set of amino acids available through prebiotic chemistry, raising a central question in molecular evolution: could such primitive compositions yie...
www.biorxiv.org
October 31, 2025 at 6:53 AM
You don't need all 20 amino acids to build proteins! Here, authors showed
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
a reduced 10-amino-acid alphabet form exceptionally stable and resistant to mutations proteins!!
A key insight into the #OriginOfLife and a new foundation for minimalist #ProteinDesign.
www.biorxiv.org/content/10.1...
Reposted
💪 Small but mighty! This JIPB mini-review explores the remarkable dual-action mechanism of #Arabidopsis cryptochromes. PlantScience onlinelibrary.wiley.com/doi/10.1111/...
February 28, 2024 at 1:20 PM
💪 Small but mighty! This JIPB mini-review explores the remarkable dual-action mechanism of #Arabidopsis cryptochromes. PlantScience onlinelibrary.wiley.com/doi/10.1111/...