Nico Barros
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nicobarrosid.bsky.social
Nico Barros
@nicobarrosid.bsky.social
960 followers 76 following 37 posts
Transplant Infectious Diseases
Indiana University
Posts Replies Media Videos
nicobarrosid.bsky.social
A must read. www.idsociety.org/globalassets...

@germhuntermd.bsky.social @natebahrid.bsky.social @fungaldoc.bsky.social
www.idsociety.org
July 9, 2025 at 11:46 PM
nicobarrosid.bsky.social
Cool article! @drboulware.bsky.social
academic.oup.com/cid/advance-...
Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstitution Inflammatory Syndrome
Hyunah Yoon, MD MS, Liise-anne Pirofski, MD, David R Boulware, MD MPH; Revisiting Immune-Mediated Mechanisms as Drivers of Cryptococcal Immune Reconstituti
academic.oup.com
June 17, 2025 at 9:43 PM
Reposted by Nico Barros
germhuntermd.bsky.social
Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge

@grthompsonmd.bsky.social and Angel Desai

www.nejm.org/doi/full/10....
Addressing Antifungal Drug Resistance — A “One Health–One World” Challenge | NEJM
Use of some antifungal pesticides may select for resistant fungi in the environment, which can then endanger human health. Coordinated regulatory processes in this area are important.
www.nejm.org
June 8, 2025 at 5:39 PM
nicobarrosid.bsky.social
Cannot agree more with @germhuntermd.bsky.social @fungaldoc.bsky.social @natebahrid.bsky.social
"Better awareness, diagnostic testing practices, and reporting are needed to improve patient outcomes and enhance our understanding of coccidioidomycosis epidemiology"

jamanetwork.com/journals/jam...
Estimated Burden of Coccidioidomycosis
This cross-sectional study generates a systematic and rigorous estimate of national incident symptomatic coccidioidomycosis cases by developing a model to account for cases missed through national sur...
jamanetwork.com
June 4, 2025 at 4:20 PM
nicobarrosid.bsky.social
Histoplasma working group ISHAM. Let's do it! 90-90-90 for 2030!
ISHAM targets 90-90-90
June 4, 2025 at 12:47 AM
Reposted by Nico Barros
germhuntermd.bsky.social
Interferon-γ therapy in patients with refractory disseminated #coccidioidomycosis

Steve Holland and colleagues in @cidjournal.bsky.social

academic.oup.com/cid/advance-...
Interferon-γ therapy in patients with refractory disseminated coccidioidomycosis
Abstract. Refractory disseminated coccidioidomycosis (DCM) is a severe disease with limited treatment options. This report reviews our own and prior publis
academic.oup.com
May 30, 2025 at 1:00 PM
nicobarrosid.bsky.social
Benedict K. and colleagues estimate that the US fungal disease related economic burden to be 19.4 billion dollar (with Dr. Evil sound effect)!!!

academic.oup.com/ofid/article...
Economic Burden of Fungal Diseases in the United States
We conservatively estimated the U.S. economic burden of fungal diseases as $11.5 billion in 2019: direct medical costs ($7.5 billion), productivity loss du
academic.oup.com
June 3, 2025 at 5:58 PM
nicobarrosid.bsky.social
Saving the best for last, Histoplasma working group
ISHAM2025 Foz do Iguaçu, Brazil
ISHAM Histoplasma working group
May 24, 2025 at 7:08 PM
nicobarrosid.bsky.social
Michael Mansour presenting about "Augmenting neutrophil function as a therapeutic strategy for high risk-patients"
Next level stuff! @mansourlab.bsky.social @mgh-id.bsky.social
Michael Mansour presenting
May 23, 2025 at 11:12 AM
nicobarrosid.bsky.social
journals.asm.org/doi/10.1128/...

Great paper! @germhuntermd.bsky.social
Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections | Clinical Microbiology Reviews
SUMMARYAntibody and antigen detection assays continue to play a significant role in the diagnosis of dimorphic fungal pathogens, including Blastomyces dermatitidis complex, Coccidioides immitis/posada...
journals.asm.org
May 22, 2025 at 8:03 PM
Reposted by Nico Barros
germhuntermd.bsky.social
Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter PK study for Screening Antifungal Exposure in Intensive Care Units (SAFE-ICU)

J Roberts etc

TLDR: ++variable, need tailored approach w TDM

link.springer.com/article/10.1...
AUC0-24/MIC for two different durations of antifungal treatment in ICU: 1-3 days vs 4-7 days, shown for various antifungals (and for caspofungin and anidulafungin shown separately for C albicans and C glabrata) PK/PD target-related exposures per occasion of the study antifungals prescribed for treatment. The shaded area represents the PK/PD target used in this study. For fluconazole, 15 data points are outside the y-axis limits (max AUC0-24/MIC value was 3250.3); ICU intensive care unit; AUC0-24 area under the plasma concentration-time curve from zero to 24 h; fAUC0-24 free AUC0-24; MIC minimum inhibitory concentration; Cmin minimum observed plasma concentration; Cmax maximum observed plasma concentration
March 11, 2025 at 12:44 PM
nicobarrosid.bsky.social
Update on the Clinical Practice Guidelines for treatment of Histoplasmosis. Thank you to all the authors @fungaldoc.bsky.social @germhuntermd.bsky.social @jobadd.bsky.social @iddoc4kids.bsky.social Nathan Bahr

www.idsociety.org/practice-gui...
Histoplasmosis (2025)
www.idsociety.org
March 10, 2025 at 12:59 PM
Reposted by Nico Barros
germhuntermd.bsky.social
From rising #TxID star (and a Canadian, no less), Patrick Tam @tamckpatrick.bsky.social

HOPE in every breath and heartbeat: Understanding transplant eligibility, access barriers, and clinical outcomes in thoracic transplantation in persons with HIV

www.jhltopen.org/article/S295...
HOPE in every breath and heartbeat: Understanding transplant eligibility, access barriers, and clinical outcomes in thoracic transplantation in persons with HIV
Persons with HIV (PWH) are living longer, leading to increased end-organ disease from chronic illness. Organ transplantation improves survival in patients with end-organ disease yet remains a constrai...
www.jhltopen.org
March 5, 2025 at 2:29 PM
nicobarrosid.bsky.social
Histoplasmosis screening was positive in 9.1% of PLWHIV with clinical manifestations suggestive of histoplasmosis (including fever, night sweats and weight loss) in a Brazilian center. More screening is required for early diagnosis and improved outcomes.

academic.oup.com/mmy/advance-...
Histoplasmosis screening using urinary antigen detection in people living with HIV in Southern Brazil
Abstract. Histoplasmosis is a life-threatening opportunistic infection in individuals with advanced HIV disease (AHD), particularly in endemic regions such
academic.oup.com
February 23, 2025 at 3:58 PM
nicobarrosid.bsky.social
Fungal sensitization syndrome may be more prevalent than currently thought. This article examines asthma as a potential coccidiodiomycosis complication.

onlinelibrary.wiley.com/doi/10.1111/...
Investigating Asthma After Coccidioidomycosis Among Patients With Commercial Health Insurance, United States, 2017–2022
Background The relationship between asthma and coccidioidomycosis has not been fully described. We have hypothesised that Coccidioides could trigger inflammatory airway responses, similar to other f...
onlinelibrary.wiley.com
February 21, 2025 at 11:44 PM
nicobarrosid.bsky.social
If it's written by @kottonnelson.bsky.social, it is a must read!

Concise expert insight into the utility of Immune monitoring assays for Cytomegalovirus.

journals.lww.com/transplantjo...
Immune Monitoring Assays: Predicting Cytomegalovirus and... : Transplantation
An abstract is unavailable.
journals.lww.com
February 21, 2025 at 8:57 PM
nicobarrosid.bsky.social
What an amazing valentines gift!

pubmed.ncbi.nlm.nih.gov/39956284/
Complement and fungal diseases - PubMed
Complement and fungal diseases
pubmed.ncbi.nlm.nih.gov
February 19, 2025 at 7:56 PM
nicobarrosid.bsky.social
A must read...amazing collaboration between different societies

Super good article. Plus it has Michael K. Mansour @mansourlab.bsky.social as an author, boom!!

www.thelancet.com/journals/lan...
Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidias...
www.thelancet.com
February 19, 2025 at 4:35 PM
nicobarrosid.bsky.social
One of the largest reports on pediatric histoplasmosis.

academic.oup.com/jpids/advanc...
Retrospective Investigation of Pediatric Histoplasmosis Diagnosed at a Tertiary Children’s Hospital in an Endemic Area over 11 years
AbstractBackground. Most histoplasmosis data are from adults. We describe pediatric histoplasmosis diagnosed at a tertiary pediatric care center in an ende
academic.oup.com
February 19, 2025 at 4:32 PM
nicobarrosid.bsky.social
This is a great commentary challenging the use of antibiotics for SBP prophylaxis in patients with cirrhosis.

academic.oup.com/cid/advance-...

I've added this review article by @arunasubramanian.bsky.social as it provides context to the question (great read).

journals.lww.com/hepcomm/full...
Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis: First, Do No Harm
Abstract. Antibiotic prophylaxis for spontaneous bacterial peritonitis (SBPPr) in patients with cirrhosis has been considered standard of care since the 19
academic.oup.com
February 12, 2025 at 10:45 AM
nicobarrosid.bsky.social
Expanding our pool (and knowledge)
Great article about the long term outcome of HBV viremic allograft use in seronegative liver and kidney transplant recipients.

journals.lww.com/journalacs/a...
Friend or Foe? Safety and Efficacy of Hepatitis B Viremic... : Journal of the American College of Surgeons
T+ and NAT-negative (–) allografts in seronegative recipients. Study Design: All recipients of an HBV core antibody-positive (HBcAb+) LT or KT were prospectively evaluated at a single transplant ce...
journals.lww.com
February 12, 2025 at 9:55 AM
nicobarrosid.bsky.social
Two good reads to accompany the Saturday morning coffee:

doi.org/10.1093/ofid... (Breakthrough invasive mold infections in hematological cases)

academic.oup.com/ofid/article...
(Adenovirus incidence on pediatric SOT)
Breakthrough Invasive Mold Infections in Hematologic Cases: Relevance of the Host's Factors
This retrospective study evaluating breakthrough invasive mould infections occurring among hematological patients highlights that host factors, including p
doi.org
February 8, 2025 at 3:10 PM
nicobarrosid.bsky.social
Fun things to read and keep us entertained during these difficult times.

"Surveillance and prevention of infection in clinical xenotransplantation"

journals.asm.org/doi/10.1128/...

Amazing article by Adam Stewart and Jay Fishman
a baby anna from the movie frozen is surrounded by snow
Alt: a baby anna from the movie frozen is surrounded by snow
media.tenor.com
February 1, 2025 at 3:03 PM
nicobarrosid.bsky.social
Check out our editorial "Beyond the test: moving forward with transplant candidates testing positive for COVID-19"

Since I wrote it with @kottonnelson.bsky.social, can I say that I'm a grownup, or not just yet?

We discuss an interesting Transplantation article:

journals.lww.com/transplantjo...
January 28, 2025 at 2:13 PM
nicobarrosid.bsky.social
What an awesome start for cocci this 2025!

Outcomes of cocci in Ab+ SOTs after stopping antifungal prophy
journals.lww.com/transplantjo...

Antifungal prophy for Cocci: how long
journals.lww.com/transplantjo...

Should we treat mild cocci in immunocompetent host
academic.oup.com/cid/advance-...
January 28, 2025 at 2:19 AM