Nicholas William Ashton
@nicholaswashton.bsky.social
Molecular cell biologist | Studying regulatory networks in the genome stability pathways | Instructor at Dana-Farber Cancer Institute and HMS | Aussie
Re-submitted manuscript awaiting decision *deep breaths*
September 30, 2025 at 5:27 PM
Re-submitted manuscript awaiting decision *deep breaths*
Big day. Submitted a grant application in the morning - my fifth of the year 😵💫 - and resubmitted a paper in the evening
September 8, 2025 at 11:15 PM
Big day. Submitted a grant application in the morning - my fifth of the year 😵💫 - and resubmitted a paper in the evening
Reposted by Nicholas William Ashton
Can we imagine a future in which everyone can use their own language to write, assess & read science with the help of AI? Read this to see why we believe this is the future of academic publishing. Great collab with @bowkerl.bsky.social & Andrew Burton-Jones. #languagebarriers
doi.org/10.1371/jour...
doi.org/10.1371/jour...
June 24, 2025 at 7:44 AM
Can we imagine a future in which everyone can use their own language to write, assess & read science with the help of AI? Read this to see why we believe this is the future of academic publishing. Great collab with @bowkerl.bsky.social & Andrew Burton-Jones. #languagebarriers
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Pleased to share a new review article of ours on USP1 inhibitors. Thank you to Carlos Torrado and Tim Yap for inviting us to contribute
www.sciencedirect.com/science/arti...
Also, check out this excellent review on a similar topic from @hw1o9.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Also, check out this excellent review on a similar topic from @hw1o9.bsky.social
www.sciencedirect.com/science/arti...
USP1 inhibition: A journey from target discovery to clinical translation
Ubiquitin-specific protease 1 (USP1) is a deubiquitinating enzyme involved in the DNA damage response. Upon DNA damage, USP1 stabilizes replication fo…
www.sciencedirect.com
May 3, 2025 at 12:19 PM
Pleased to share a new review article of ours on USP1 inhibitors. Thank you to Carlos Torrado and Tim Yap for inviting us to contribute
www.sciencedirect.com/science/arti...
Also, check out this excellent review on a similar topic from @hw1o9.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Also, check out this excellent review on a similar topic from @hw1o9.bsky.social
www.sciencedirect.com/science/arti...
Presented a poster today at a Dana-Farber symposium. I was asked by three people whether I am a PhD student. Glad to know I haven’t outwardly aged too much over the past decade.
March 28, 2025 at 5:31 PM
Presented a poster today at a Dana-Farber symposium. I was asked by three people whether I am a PhD student. Glad to know I haven’t outwardly aged too much over the past decade.
According to the Office of Research Integrity, most drivers of research misconduct are due to work and/or life pressures. What a shock.
February 25, 2025 at 7:20 PM
According to the Office of Research Integrity, most drivers of research misconduct are due to work and/or life pressures. What a shock.
We are getting some good data!
January 25, 2025 at 1:09 PM
We are getting some good data!
Something amazing has happened at work. The building maintenance team has emptied and cleaned the fridges in our break room. The first time in living memory. And from now on they will be emptied once per month.
January 25, 2025 at 1:05 PM
Something amazing has happened at work. The building maintenance team has emptied and cleaned the fridges in our break room. The first time in living memory. And from now on they will be emptied once per month.
Today, the technician I am supervising said to me, in relation to our project, 'you know, this is actually pretty cool'. It made my day.
January 17, 2025 at 1:39 AM
Today, the technician I am supervising said to me, in relation to our project, 'you know, this is actually pretty cool'. It made my day.
I am proud to share that after several years of on-again, off-again effort, I have finally finished Marcel Proust's 'In Search of Lost Time' (translation by Moncrieff and Kilmartin). It was one of the most incredible novels I have read, as well as one of the most difficult.
December 11, 2024 at 1:24 AM
I am proud to share that after several years of on-again, off-again effort, I have finally finished Marcel Proust's 'In Search of Lost Time' (translation by Moncrieff and Kilmartin). It was one of the most incredible novels I have read, as well as one of the most difficult.
Today I assembled a new UV-C irradiation system. Parts include: a handheld UV lamp, a cardboard box, a polystyrene box, a piece of plywood, a step-up transformer and a UV dose metre. Stable output of 40 uW/cm2
November 14, 2024 at 8:46 PM
Today I assembled a new UV-C irradiation system. Parts include: a handheld UV lamp, a cardboard box, a polystyrene box, a piece of plywood, a step-up transformer and a UV dose metre. Stable output of 40 uW/cm2
Three days later and I can walk up and down stairs again.
November 13, 2024 at 2:19 PM
Three days later and I can walk up and down stairs again.
I am pleased to share our latest preprint. In this work we show that the ubiquitin-binding domain of Pol eta interacts with NEDD8, and that this interaction is required for Pol eta mono-NEDDylation. Looking forward to having this work published-published. www.biorxiv.org/content/10.1...
DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation
DNA polymerase eta (Pol η) is a Y-family translesion polymerase responsible for synthesizing new DNA across UV-damaged templates. It is recruited to replication forks following mono-ubiquitination of ...
www.biorxiv.org
November 13, 2024 at 1:12 PM
I am pleased to share our latest preprint. In this work we show that the ubiquitin-binding domain of Pol eta interacts with NEDD8, and that this interaction is required for Pol eta mono-NEDDylation. Looking forward to having this work published-published. www.biorxiv.org/content/10.1...